Three new monoterpene glucosides and one new sorbitol ester identified from Sibiraea angustata with hypolipidemic activities in HepG2 cells

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Zheng-Zheng Yao, Hong-Dong Liu, Xiao-Tian Chen, Dong-Ming Zhang, Xue-Wen Lai, Peng Xu, Bin Li Three new monoterpene glycosides, sibiraglycoside L (1), M (2), N (3) and one new sorbitol ester, resibirate (4), together with four known compounds including caffeic acid glucitol ester (5), sibiscolacton C (6), geraniol-1-O-[α-l-rhamnopyranosyl-(1→6)-1-β-d-glucopyranoside] (7), and sibiraglycoside K (8), respectively, were isolated from an aqueous extract of the aerial portion of Sibiraea angustata. Their structures were elucidated on the basis of extensive spectroscopic data analysis (including 13CNMR,1HNMR, HSQC, HMBC,1H-1H COSY, ROESY, HRESIMS, MS and CD experiments) and comparison to previously reported data. In addition, a preliminary evaluation of the hypolipidemic activities of these compounds is presented, some compounds showed moderate hypolipidemic activities in HepG2 cells. Graphical abstract

Source: Phytochemistry Letters - June 27, 2017 Category: Chemistry Source Type: research