The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20 –40 Months of Age: Evidence from Rural Bangladesh

Conclusions: Employing a novel statistical method for the study of the health effects of chemical mixtures, we found evidence of neurotoxicity of the mixture, as well as potential synergism between arsenic and manganese. https://doi.org/10.1289/EHP614 Received: 27 January 2016 Revised: 07 June 2016 Accepted: 18 October 2016 Published: 26 June 2017 Address correspondence to L. Valeri, Laboratory for Psychiatric Biostatistics, McLean Hospital, 115 Mills St., Belmont, MA, USA. Telephone: 617-855-2561. Email: lvaleri@mclean.harvard.edu Supplemental Material is available online (https://doi.org/10.1289/EHP614). The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Supplemental Material PDF (904 KB) Supplemental Code and Data Zip File (206 KB) Note to readers with disabilities: EHP has provided a 508-conformant table of contents summarizing the Supplemental Material for this article (see below) so readers with disabilities may determine wh...
Source: EHP Research - Category: Environmental Health Authors: Tags: Review Source Type: research

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CONCLUSION: Based on these findings, we assert that the current system in the United States for evaluating scientific evidence and making health-based decisions about environmental chemicals is fundamentally broken. To help reduce the unacceptably high prevalence of neurodevelopmental disorders in our children, we must eliminate or significantly reduce exposures to chemicals that contribute to these conditions. We must adopt a new framework for assessing chemicals that have the potential to disrupt brain development and prevent the use of those that may pose a risk. This consensus statement lays the foundation for developi...
Source: EHP Research - Category: Environmental Health Authors: Tags: Brief Communication July 2016 Source Type: research
Conclusions Patterns of disease are changing rapidly in LMICs. Pollution-related chronic diseases are becoming more common. This shift presents a particular problem for children, who are proportionately more heavily exposed than are adults to environmental pollutants and for whom these exposures are especially dangerous. Better quantification of environmental exposures and stepped-up efforts to understand how to prevent exposures that cause disease are needed in LMICs and around the globe. To confront the global problem of disease caused by pollution, improved programs of public health monitoring and environmental protecti...
Source: EHP Research - Category: Environmental Health Authors: Tags: Brief Communication March 2016 Source Type: research
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