The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20 –40 Months of Age: Evidence from Rural Bangladesh

Conclusions: Employing a novel statistical method for the study of the health effects of chemical mixtures, we found evidence of neurotoxicity of the mixture, as well as potential synergism between arsenic and manganese. Received: 27 January 2016 Revised: 07 June 2016 Accepted: 18 October 2016 Published: 26 June 2017 Address correspondence to L. Valeri, Laboratory for Psychiatric Biostatistics, McLean Hospital, 115 Mills St., Belmont, MA, USA. Telephone: 617-855-2561. Email: Supplemental Material is available online ( The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact Our staff will work with you to assess and meet your accessibility needs within 3 working days. Supplemental Material PDF (904 KB) Supplemental Code and Data Zip File (206 KB) Note to readers with disabilities: EHP has provided a 508-conformant table of contents summarizing the Supplemental Material for this article (see below) so readers with disabilities may determine wh...
Source: EHP Research - Category: Environmental Health Authors: Tags: Review Source Type: research

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Publication date: February 2020Source: Alter, Volume 14, Issue 1Author(s):
Source: ALTER - European Journal of Disability Research - Category: Disability Source Type: research
Authors: Zeng Q, Zhao L, Wang C, Gao M, Han X, Chen C, Tu C, Han P, Li J Abstract Background: A high prevalence of autoimmune thyroid disease (AITD) has been observed in patients with autoimmune liver disease (AILD); however, data on the clinical relationship between AILD and AITD remain scant. We aimed to evaluate the relationship between AILD and AITD.Methods: We performed a retrospective study using medical records from 324 patients with AILD, 113 of whom had concurrent AITD.Results: Patients with autoimmune hepatitis (AIH) were more likely to develop AITD (45.8%), followed by autoimmune hepatitis-primary biliar...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
This study aims to develop a machine-learning empowered technique to quantify to what extent an individual's bladder is filled by observing the filling-voiding pattern of a patient over a training period. In this experiment, a pulse-echo sonar element is used to generate ultrasound pulses while the probe surface is positioned perpendicular to the bladder's position. From the reflected echoes, four features which show sufficient sensitiveness and therefore could be modulated noticeably by different levels of liquid encased in the bladder, are extracted. The extracted features are then fed into a novel intelligent decision s...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Publication date: 1 June 2020Source: Chemical Engineering Journal, Volume 389Author(s): Honglei Yang, Shuwen Li, Ruifa Jin, Zhounan Yu, Guangxue Yang, Jiantai MaAbstractThe development of superior supporting materials supported surface-engineered metallic nanocrystals is desired and necessary for promoting the electrocatalytic performance of ethanol electroxidation. Additionally, the facile and mild synthetic strategy for advanced electrocatalyst is also urgently needed. Herein, a new catalyst comprising of phosphorus low-doping palladium nanoalloys uniformly anchored on the three-dimensional nitrogen-doped graphene (denot...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 23 February 2020Source: Composites Science and TechnologyAuthor(s): Elena Dilonardo, Michele Nacucchi, Fabio De Pascalis, Mauro Zarrelli, Cinzia GianniniAbstractThe aim of the current study is to propose a versatile, non-destructive inspection strategy to evaluate the structure of two different aircraft carbon fibre reinforced polymer (CFRP) -based composite configurations, which are widely used for structural elements, respectively layered composite and sandwich structure. X-ray computed tomography (CT) has been used as a flexible method for assessment of porosity levels in CFRP componen...
Source: Composites Science and Technology - Category: Science Source Type: research
ConclusionsUS may underestimate breast tumor size. Treatment decisions that take into account tumor size can be made equally reliably in patients with high or low breast density.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionCumulatively, our data demonstrated that circulating exosomes from the placenta and activated immune cells potentially influence inflammatory cytokine production in pre-eclamptic pregnancies.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
PMID: 32080036 [PubMed - in process]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
CONCLUSION: Based on these findings, we assert that the current system in the United States for evaluating scientific evidence and making health-based decisions about environmental chemicals is fundamentally broken. To help reduce the unacceptably high prevalence of neurodevelopmental disorders in our children, we must eliminate or significantly reduce exposures to chemicals that contribute to these conditions. We must adopt a new framework for assessing chemicals that have the potential to disrupt brain development and prevent the use of those that may pose a risk. This consensus statement lays the foundation for developi...
Source: EHP Research - Category: Environmental Health Authors: Tags: Brief Communication July 2016 Source Type: research
Conclusions Patterns of disease are changing rapidly in LMICs. Pollution-related chronic diseases are becoming more common. This shift presents a particular problem for children, who are proportionately more heavily exposed than are adults to environmental pollutants and for whom these exposures are especially dangerous. Better quantification of environmental exposures and stepped-up efforts to understand how to prevent exposures that cause disease are needed in LMICs and around the globe. To confront the global problem of disease caused by pollution, improved programs of public health monitoring and environmental protecti...
Source: EHP Research - Category: Environmental Health Authors: Tags: Brief Communication March 2016 Source Type: research
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