Maternal Obesity and Cerebral Palsy in Offspring —Reply

In Reply Mr Li and Dr Li raise 3 points. First, they note that the analyses did not adjust for important confounding factors including maternal diabetes and hypertension. Gestational diabetes and pregnancy-induced hypertensive diseases are not confounders of the association between early pregnancy BMI and cerebral palsy because they are generally regarded as consequences, not causes, of maternal obesity. Similarly, overweight and obesity increase risks of manifest (type 1 or type 2) diabetes and essential hypertension in a dose-response manner.
Source: JAMA - Category: General Medicine Source Type: research