Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging

CONCLUSIONSAsymptomatic young adult survivors of childhood ALL demonstrate a biologic profile of chronic inflammation and telomere attrition, consistent with an early onset of cellular processes that drive accelerated aging. These processes may explain the premature development of age‐related chronic conditions in childhood cancer survivors. Understanding their molecular basis may facilitate targeted interventions to disrupt the accelerated aging process and its long‐term impact on overall health. Cancer 2017. © 2017 American Cancer Society.

Source: Cancer - June 27, 2017 Category: Cancer & Oncology Authors: Hany Ariffin, Mohamad Shafiq Azanan, Sayyidatul Syahirah Abd Ghafar, Lixian Oh, Kee Hie Lau, Tharshanadhevasheri Thirunavakarasu, Atiqah Sedan, Kamariah Ibrahim, Adelyne Chan, Tong Foh Chin, Fong Fong Liew, Shareni Jeyamogan, Erda Syerena Rosli, Rashidah Tags: Original Article Source Type: research