ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer.

ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer. BMB Rep. 2017 Jun 26;: Authors: Wang X, Xia Y, Xu C, Lin X, Xue P, Zhu S, Bai Y, Chen Y Abstract Endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohistochemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, and invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overexpression in BGC823 cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor. This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored. PMID: 28648145 [PubMed - as supplied by publisher]
Source: BMB Reports - Category: Biochemistry Authors: Tags: BMB Rep Source Type: research