Functional roles of CTCF in breast cancer.

Functional roles of CTCF in breast cancer. BMB Rep. 2017 Jun 26;: Authors: Oh S, Oh C, Yoo KH Abstract CTCF, Zn-finger protein, has been identified as multifunctional transcription factor to regulate gene expression through recruitment of other co-activators and binding to promoter regions of target genes. Furthermore, it has been proposed as an insulator protein that contributes to the establishment of functional three-dimensional chromatin structures. It could disrupt transcription through block the connection between enhancer and promoter. Previous studies revealed that various diseases including breast cancer were developed from aberrant expression of CTCF itself or their target genes. In this review, we will describe dysfunction of CTCF that induces tumorigenesis and summarize the functional roles of CTCF in breast cancer. PMID: 28648147 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28648147?dopt=Abstract

Source: BMB Reports - June 26, 2017 Category: Biochemistry Authors: Oh S, Oh C, Yoo KH Tags: BMB Rep Source Type: research