Statistical Approaches for Estimating Sex-Specific Effects in Endocrine Disruptors Research

Conclusions:
Investigators should consider sexual heterogeneity of confounder associations when choosing an analytic approach to estimate sex-specific effects of endocrine disruptors on health. In the presence of sex-dependent confounding, our augmented product term approach may be advantageous over stratification when there is prior knowledge available to fit reduced models or when investigators seek an automated test for effect measure modification. https://doi.org/10.1289/EHP334

Received: 08 April 2016
Revised: 29 November 2016
Accepted: 12 December 2016
Published: 23 June 2017
Address correspondence to J.P. Buckley, Departments of Environmental Health and Engineering and Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Room W7513A, Baltimore, MD 21205 USA. Telephone: [phone]. Email: [e-mail]
Supplemental Material is available online (https://doi.org/10.1289/EHP334).
The authors declare they have no actual or potential competing financial interests.
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Source: EHP Research - June 24, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research