Extracellular cytochrome c as an intercellular signaling molecule regulating microglial functions

Conclusions Extracellular cytochrome c can interact with microglia TLR4 and modulate select functions of these brain immune cells. General significance Our data identifies extracellular cytochrome c as a potential intercellular signaling molecule, which may be recognized by microglia causing or enhancing their immune activation. The data obtained support targeting TLR4 and JNK signaling as potential treatment strategies for brain diseases characterized by excessive cellular death and activation of microglia.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research