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Biochemical Effects of the Aqueous Extract of Hibiscus sabdariffa on Liver Marker Enzymes and Lipid Profiles in Acetaminophen-challenged Rats

This study was conducted to determine the hepato-regenerative properties of aqueous extract of Hibiscus sabdariffa leaves in acetaminophen induction of the liver by using rat model. Materials and Methods: Twenty Wistar Albino rats were used for this study and were divided into four groups. Group 1 rats were normal control group 2 (positive control) rats were administered acetaminophen only at a dose of 750 mg kg–1 b.wt., i.p. Both rats of group 3 and 4 were administered low and high doses respectively at 600 mg kg–1 b.wt., of the extract after induction of acetaminophen. The results were analyzed using one way analysis of variance using SPSS version 20. Results: Group 2 rats treated with acetaminophen only showed significant increase (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Kyröläinen, H, Hackney, AC, Salminen, R, Repola, J, Häkkinen, K, and Haimi, J. Effects of combined strength and endurance training on physical performance and biomarkers of healthy young women. J Strength Cond Res 32(6): 1554–1561, 2018—Cardiovascular fitness has decreased and obesity has increased in young adults worldwide during the last 10 years. Therefore, there is an urgent need to find out optimal exercise training programs for improving physical performance and health outcomes, especially among sedentary women. Subjects were 25- to 30-year-old women with a very low physical activity, and 6...
Source: Journal of Strength and Conditioning Research - Category: Sports Medicine Tags: Original Research Source Type: research
Publication date: August 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Volume 1863, Issue 8 Author(s): Patrick Drücker, Simon Bachler, Heidi Wolfmeier, Roman Schoenauer, René Köffel, Viktoria S. Babiychuk, Petra S. Dittrich, Annette Draeger, Eduard B. Babiychuk Nucleated cells eliminate lesions induced by bacterial pore-forming toxins, such as pneumolysin via shedding patches of damaged plasmalemma into the extracellular milieu. Recently, we have shown that the majority of shed pneumolysin is present in the form of inactive pre-pores. This finding is surprising co...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
Conclusions HSP70 promotes the progression of atherosclerosis in apoE−/− mice by suppressing the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway.
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
Publication date: Available online 18 May 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Yidan Sun, Susanne Kopp, Jasmin Strutz, Chaitanya Chakravarthi Gali, Martina Zandl-Lang, Elham Fanaee-Danesh, Andrijana Kirsch, Silvija Cvitic, Saša Frank, Richard Saffery, Ingemar Björkhem, Gernot Desoye, Christian Wadsack, Ute Panzenboeck Gestational diabetes mellitus (GDM) is associated with excessive oxidative stress which may affect placental vascular function. Cholesterol homeostasis is crucial for maintaining fetoplacental endothelial function. We aimed to investiga...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
ConclusionThe proportion of older adults in Australia using statins has increased over the last decade, although the incidence has declined. Atorvastatin is the most commonly dispensed statin and the use of high intensity statin has increased.
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
This study confirmed the influencing factors (such as a HFD and female gender) of hypercholesterolemia in IUGR offspring providing theoretical and experimental bases for the effective prevention of fetal-originated hypercholesterolemia.
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
CONCLUSIONS: Awareness of target values for lipid management and of adverse reactions to drug therapy appears to vary somewhat depending on the participant's medical specialty. We also found that FH is probably underdiagnosed in Japan today. Further educations on proper diagnosis and management of dyslipidemia are required for physicians who are not specialized in cardiovascular health. PMID: 29780067 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Conclusions The prevalence of thyroid dysfunction was significantly different according to lipid profiles, and this association differed by age and gender. PMID: 29779453 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Statins are commonly used for the primary and secondary prevention of cardiovascular events; however, statins are underused in patients with noncoronary atherosclerosis. We sought to establish the rates of statin use in patients with carotid artery disease, and examine the association between statin therapy and clinical outcomes among an elderly population after carotid artery revascularization.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Conclusions from landmark trials investigating medical versus surgical management of asymptomatic carotid occlusive disease may not be supported with the advancement of statin therapy for lipid management. We set out to evaluate the current understanding of the natural history of asymptomatic, severe internal carotid artery (ICA) stenosis through an analysis of our own results, which, in turn, will optimize our practice patterns and improve patient outcomes.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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