Biochemical Effects of the Aqueous Extract of Hibiscus sabdariffa on Liver Marker Enzymes and Lipid Profiles in Acetaminophen-challenged Rats

This study was conducted to determine the hepato-regenerative properties of aqueous extract of Hibiscus sabdariffa leaves in acetaminophen induction of the liver by using rat model. Materials and Methods: Twenty Wistar Albino rats were used for this study and were divided into four groups. Group 1 rats were normal control group 2 (positive control) rats were administered acetaminophen only at a dose of 750 mg kg–1 b.wt., i.p. Both rats of group 3 and 4 were administered low and high doses respectively at 600 mg kg–1 b.wt., of the extract after induction of acetaminophen. The results were analyzed using one way analysis of variance using SPSS version 20. Results: Group 2 rats treated with acetaminophen only showed significant increase (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Authors: Okopień B, Bułdak Ł, Bołdys A Abstract INTRODUCTION: The need to reduce residual cardiovascular risk led to the development of novel therapeutic strategies to improve patients' outcomes. The residual risk in people with atherogenic dyslipidemia, despite LDL reduction obtained mainly by statins, remains high. Fibrates in those patients lead to significant clinical improvements. Those include reduction in the progression of atherosclerosis, which translates into decrease in cardiovascular events and improvements in microvascular diabetic complications. Furthermore there are other clinical and biochemical...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Authors: Hassan A, Jaffe R, Rubinshtein R, Karkabi B, Halon DA, Flugelman MY, Zafrir B Abstract BACKGROUND: Contemporary data on clinical profiles and long-term outcomes of young adults with coronary artery disease (CAD) are limited. OBJECTIVES: To determine the risk profile, presentation, and outcomes of young adults undergoing coronary angiography. METHODS: A retrospective analysis (2000-2017) of patients aged ≤ 35 years undergoing angiography for evaluation and/or treatment of CAD was conducted. RESULTS: Coronary angiography was performed in 108 patients (88% males): 67 acute coronary syndrome (AC...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Though heart is known primarily as a pump, it is the four cardiac valves that ensures the critical , non-stop unidirectional flow that sustain the circulation . It is to be recalled these valves originate in the very early days of cardiac development when the primitive heart tube loops , even as the chambers expand from primitive ventricle. Mesenchymal differentiation controlled by various genes that cleaves the valve from myocardial tissue. While heart by itself is the supreme vascular organ ,  its surprising  few structures inside the heart , like the valves are quiet avascular ( or is it really so ?)...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: cardiac embryology Embryology : Heart valve development Infective endocarditis : Pathology valvular heart disease blood supply to heart valves hematogenous spread of infective endocarditis how bacteria reach mitral valve in infective endocardi Source Type: blogs
Your body doesn’t like things to be too easy. Challenging it from time to time—with exercise, with the elements, and even with short periods of going without food—is often associated with better health outcomes. The same is true of your gut and the foods it digests. Foods that break down and slip through too quickly (namely, refined starches and sugars) tend to promote overeating, out-of-control blood sugar surges, and other disease-linked side effects. Meanwhile, foods that put up a bit of a fight against digestion are often the best ones for you. That’s certainly true in the case of fiber, which i...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition Source Type: news
This can help to reduce cholesterol levels, research finds. → Enjoying these psych studies? Support PsyBlog for just $4 per month (includes ad-free experience and more articles). → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: NEW: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Stress Source Type: blogs
This study was designed to evaluate the impact of Citrus unshiu peel pellet (CUPP) on obesity and lipid profile. Methods: For 118 patients with body mass index (BMI)> 23 who took Citrus unshiu peel pellet (CUPP) for 4 weeks in a Public Health Center, laboratory and biometric readings before and after CUPP administration were analyzed. Results: Mean age of these subjects was 53.8±10.6 years (range: 18-75 years). There were 88 (74.6%) females in the study sample (n = 118). A significant (p
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
We report a case of a 52-year-old man who had undergone left anterior descending artery stent implantation for unstable angina 5 years previously. He underwent CMR imaging for screening of vulnerable plaques. A lesion in the proximal right coronary artery showed HIP on non-contrast T1WI. Invasive coronary angiography showed progressive stenosis and PCI was performed. Non-contrast T1WI indicated a high risk for a slow-flow phenomenon. A distal protection device (Parachute™ (Tri-Med, Osaka, Japan)) was deployed at the distal site of the lesion. Following balloon dilation, a filter no-reflow phenomenon developed. C...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
CONCLUSION: S100A4 was detected to be upregulated in NAFLD, while S100A4 KO alleviated liver fibrosis and inflammation, in addition to inhibiting hepatocyte apoptosis. PMID: 30328321 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
Abstract PURPOSE: Coronary artery spasm (CAS) and diabetes mellitus (DM) are implicated in endothelial dysfunction, and insulin resistance (IR) is a major etiological cause of type 2 DM. However, the association between CAS and IR in non-diabetic individuals has not been elucidated. The aim of the present study was to evaluate the impact of IR on CAS in patients without DM. MATERIALS AND METHODS: A total of 330 eligible patients without DM and coronary artery disease who underwent acetylcholine (Ach) provocation test were enrolled in this study. Inclusion criteria included both hemoglobin A1c
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
Publication date: December 2018Source: IJC Heart &Vasculature, Volume 21Author(s): Ali Momeni, Abdolmajid Taheri, Maryam Mansuri, Ali Bazdar, Morteza Sedehi, Masoud AmiriAbstractAimsAtherosclerosis and ischemic heart disease are more common in diabetic patients. Atherosclerosis process can disturb the normal functioning of the vascular endothelium and increase vessel wall thickness. The aim of this study was the comparison of Carotid intima-media thickness (CIMT) with Exercise tolerance test as an alternative way to evaluate cardiac ischemia in diabetic patients.MethodsIn a cross-sectional study, 30 diabetic patients w...
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
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