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Biochemical Effects of the Aqueous Extract of Hibiscus sabdariffa on Liver Marker Enzymes and Lipid Profiles in Acetaminophen-challenged Rats

This study was conducted to determine the hepato-regenerative properties of aqueous extract of Hibiscus sabdariffa leaves in acetaminophen induction of the liver by using rat model. Materials and Methods: Twenty Wistar Albino rats were used for this study and were divided into four groups. Group 1 rats were normal control group 2 (positive control) rats were administered acetaminophen only at a dose of 750 mg kg–1 b.wt., i.p. Both rats of group 3 and 4 were administered low and high doses respectively at 600 mg kg–1 b.wt., of the extract after induction of acetaminophen. The results were analyzed using one way analysis of variance using SPSS version 20. Results: Group 2 rats treated with acetaminophen only showed significant increase (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Abstract The aim of this study was to verify general and central obesity, as well as the association of anthropometric indicators with cardiovascular risk factors (CvRF) in teachers of the private network of Vi çosa-MG. A cross-sectional observational study was conducted with 150 teachers. Body Mass Index (BMI), Conicity Index (CI), Body Adiposity Index (BAI), Waist-to-Hip Ratio (WHR), Waist-to-Height Ratio (WHtR), Waist Circumference (WC), Abdominal Circumference (AC) and Body Fat Percentage (%BF); Systo lic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP); Glycemia (GL), Total Cholesterol (TC), High Density...
Source: Revista Brasileira de Cineantropometria e Desempenho Humano - Category: Sports Medicine Source Type: research
Publication date: 21 February 2018 Source:The Lancet, Volume 391, Supplement 1 Author(s): Basma R Damiri, Amir Agbar, Saja Al-Khdour, Yousef Arafat Background Metabolic syndrome is one of the main reasons for elevated mortality worldwide. The aim of this study was to characterise and establish sex-adjusted prevalence of metabolic syndrome in young Palestinian adults. Methods This cross-sectional study was done at An-Najah National University in 2014 using International Diabetes Federation (IDF) and modified National Cholesterol Education Program-Third Adult Treatment Panel (NCEP) definitions. Approval was obtained from th...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: 5 April 2018 Source:International Journal of Pharmaceutics, Volume 540, Issues 1–2 Author(s): Toshiki Fuse, Tatsuaki Tagami, Masafumi Tane, Tetsuya Ozeki Triggered drug release is a promising strategy for delivering anticancer drugs to cancer cells and tissues. We found that liposomes co-encapsulating calcein (a water-soluble model drug and fluorescence marker) and talaporfin sodium (TPS, a water-soluble photosensitizer) released the drug upon irradiation with a near-infrared (NIR)-laser. The liposomes were composed of phospholipid (DSPC)/helper lipid (DOPE)/cholesterol/PEG-lipid (PEG2000-DSPE) at ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: 5 April 2018 Source:International Journal of Pharmaceutics, Volume 540, Issues 1–2 Author(s): M. Matbou Riahi, A. Sahebkar, K. Sadri, S. Nikoofal-Sahlabadi, M.R. Jaafari Celecoxib (CLX) is a selective COX-2 inhibitor with anticancer potential in a COX-2 dependent and independent manner. CLX’s low water solubility has a dose limiting effect on its utilization in cancer treatment. Here, we developed liposomal drug delivery systems to allow a systemic administration and increase tumor accumulation of CLX based on the enhanced permeability and retention (EPR) mechanism. Nine liposomal formulation...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: 2018 Source:Handbook of Clinical Neurology, Volume 148 Author(s): Susana Carmona, John Hardy, Rita Guerreiro Alzheimer disease (AD), a progressive and neurodegenerative disease, is the most common form of dementia with high incidence in elderly people. Neuropathologically the disease is defined by the combined presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles of phosphorylated tau protein. Genetically, the first clues were provided by genetic linkage studies that led to the identification of APP, PSEN1, and PSEN2 mutations as the main causes of autosomal-d...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
Publication date: 2018 Source:Handbook of Clinical Neurology, Volume 148 Author(s): Craig Blackstone The hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurologic disorders with the common feature of prominent lower-extremity spasticity, resulting from a length-dependent axonopathy of corticospinal upper motor neurons. The HSPs exist not only in “pure” forms but also in “complex” forms that are associated with additional neurologic and extraneurologic features. The HSPs are among the most genetically diverse neurologic disorders, with well over 70 distinct genetic loci, for whic...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
(Reuters Health) - Compared to inactive people, recreational soccer players have lower cholesterol, blood pressure and resting heart rates as well as less fat mass, a research review suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Authors: Farkas GJ, Gorgey AS, Dolbow DR, Berg AS, Gater DR Abstract OBJECTIVE: We aimed to examine the influence of sex on the distribution of adipose tissue, as well as proinflammatory adipokine and cardiometabolic profiles, in chronic motor complete spinal cord injury (SCI). DESIGN: Cross-sectional and correlational study. SETTING: Academic rehabilitation hospital. PARTICIPANTS: Forty-seven individuals with chronic motor complete SCI classified according to sex (males: age 44.0 ± 10.9 y, body mass index (BMI) 27.2 ± 5.8, level of injury (LOI) C4 - L1; females...
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
This recipe is rich with goodness and flavor — and is comfort food at its best. The ingredients are simple: Quality grass-fed beef is married together with vegetables and a few glasses of full-bodied red wine. I’ve used carrot puree to thicken the Bourguignon sauce towards the end of cooking, which is a lovely way of thickening sauces without using refined white flours. Don’t overcook your cauliflower. Make sure to chop the ingredients finely before cooking and keep an eye on the cooking time. Blend it when hot, which will result in a creamy, white mash that tastes wonderful. This recipe is from my cookbo...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cooking diet Food healthytime weekend recipe Source Type: news
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