New phenolic glycosides with cyclooxygenase inhibition from the roots of Tecoma mollis

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Wael M. Abdel-Mageed, Lamya H. Al-Wahaibi, Enaam Y. Backheet, Ali A. El-Gamal, Yaser G. Gouda, Omer A. Basudan, Maged S. Abdel-Kader, Azza A. Khalifa Three new phenolic glycosides (1–3) together with nine known ones were isolated from the roots of Tecoma mollis using DPPH radical scavenging bioassay-guided chromatographic separation. The structures of the new compounds were established using extensive spectroscopic data and HR-MS. The antioxidant, COX-2 inhibition, and cytotoxic activities were evaluated for the isolated compounds. Compound 4 displayed the strongest radical scavenging activity relative to ascorbic acid with IC50 8.7μM. Compounds 5, 6, and 10 showed promising COX-2 inhibitory action, IC50 values of 11.3μM, 9.4μM, and 13.4μM, respectively. All compounds exhibited weak cytotoxic activity against Hela and A549 cancer cell lines. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Authors: Abdellatif AAH Abstract Numerous normal and tumors cells are well-known to express the somatostatin receptors (SSTRs) on their surface which make the receptor be useful for tumor scintigraphy. Thus, identification of SSTRs is beneficial, especially SSTR2. The somatostatin analogue, Octreotide (OCT) was chosen as a ligand, as it is known to selectively bind to SSTR2. Moreover, polyethylene glycol (PEG), 8armPEG was used as a branched PEG to provide a low non-specific cell binding and easily chemical modification. OCT, and fluorescein (Flu) were conjugated to branched PEG using a water-soluble carbodiimide (...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
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Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
We appreciate the interest that Roncati and Piscioli showed in our recent publication, in which we evaluated the risk of sentinel lymph node (SLN) metastases in nonulcerated, T1b melanoma by the new 8th edition American Joint Committee on Cancer (AJCC) staging criteria.1 The authors propose a model of melanoma progression based on the transition from a radial growth phase to a vertical growth phase (VGP) that can predict biologic aggressiveness and propensity to metastasize.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research
In comparison with the 7th Edition, the 8th Edition of the American Joint Committee on Cancer (AJCC) staging system for melanoma no longer considers the mitotic count in the a or b T1 categorization, but it adopts a sub-stratification based on Breslow depth: T1a ≤ 0.8 mm without ulceration and T1b ≤ 0.8 mm with ulceration or 0.8 to 1 mm with or without ulceration. Skin melanoma can be subdivided by Breslow depth into thin melanoma (≤1 mm) or thick melanoma (>1  mm). According to the AJCC 8th Edition, a and b specifications are assigned based on ulceration and depth, which replace the mitotic count for square millimeter.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
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Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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