Ent-kaurene diterpenoids and lignan from Leontopodium leontopodioides and their inhibitory activities against cyclooxygenases-1 and 2

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Chu-Lu Qi, En Wang, Li-Qin Jin, Ming Yan, Xiao-Qi Zhang, Hao Wang, Wen-Cai Ye Two new ent-kaurene diterpenoids, 13α,15α-dihydroxy-18-carboxy-19-nor-ent-kaur-16-ene-2β-O-(2′-angelate)-β-d-glucopyranoside (leontocin A, 1), 13α,15α-dihydroxy-18-carboxy-19-nor-ent-kaur-16-ene-2β-O-(2′-angelate-6′-acetyl)-β-d-glucopyranoside (leontocin B, 2), and one new lignan, 2,3-bis[(3,4-di-hydroxyphenyl)methylene]-monoethyl ester-butanedioic acid (leontolignan A, 3), together with three known phenolic acids (4-6) were isolated from the aerial parts of Leontopodium leontopodioides (Asteraceae). Their structures were elucidated by chemical and spectroscopic methods. All isolates were evaluated for their anti-inflammatory activities by measuring their inhibitory effects against cyclooxygenase-1 and 2 in vitro. Graphical abstract

Source: Phytochemistry Letters - June 23, 2017 Category: Chemistry Source Type: research