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Long ‐term outcome of anorexia nervosa: Results from a large clinical longitudinal study

DiscussionMany patients with very severe AN recover from their illness but AN also shows considerable long‐term negative consequences. Over long time periods, survivors show improvement but better treatments for severe cases are still needed. Predictors of outcome included symptom severity, chronicity, and length of follow‐up but not psychiatric comorbidity.
Source: International Journal of Eating Disorders - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Alpha diversity lower in anorexia nervosa, obese participants versus other groups; highest for athletes
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Family Medicine, Gastroenterology, Gynecology, Pathology, Pediatrics, Pharmacy, Psychiatry, Journal, Source Type: news
In this study we investigated how to optimize tolerability while maintaining efficacy of a novel, highly potent dual amylin and calcitonin receptor agonist (DACRA), KBP-089. Furthermore, we tested the GLP-1 add-on potential of KBP-089 in high-fat diet (HFD)-fed rats. KBP-089 potently activated both the amylin and calcitonin receptors in vitro and demonstrated a prolonged receptor activation as well as a potent reduction of acute food intake. HFD rats dosed every day or every second day obtained equal weight loss at study end, albeit with an uneven reduction in both food intake and body weight in rats dosed every second day...
Source: AJP: Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: Research Article Source Type: research
HealthDay News) -- Anorexia nervosa is an eating disorder that's triggered by the misperception that a person is overweight. This causes the person to eat less, triggering dangerous weight loss. People tend to develop anorexia in their teens or...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
CONCLUSION: In conclusion, further studies are needed to clarify the effect of OO net of possible synergistic effects with other dietary and lifestyle factors of Mediterranean area. PMID: 29165098 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Endocrinology Authors: Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Women who suffer from obesity or anorexia nervosa present lower level of allopregnanolone, a neuroactive steroid linked to depression and anxiety.Psych Central
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Date: Monday, 12 04, 2017; Speaker: Ellen Conway, Pigment epithelium-derived factor (PEDF) across wide BMI- anorexia to obesity , The Rother group, DEOB, NIDDK; Luiz Barella, Critical role of beta-arrestin-1 in beta cell function in vitro and in vivo, The Wess group, LBC, NIDDK; Building: Building 10 (Clinical Center); Solarium Conference Room 9S233 (old Bunim Room)
Source: NIH Calendar of Events - Category: American Health Source Type: events
Summary Fatty acid ethanolamides are lipid mediators that regulate a plethora of physiological functions. One such bioactive lipid mediator, oleoylethanolamide (OEA), is a potent agonist of the peroxisome proliferator‐activated receptor‐alpha (PPAR‐α), which modulates increased expression of the fatty acid translocase CD36 that enables the regulation of feeding behaviour. Consumption of dietary fat rich in oleic acid activates taste receptors in the gut activating specific enzymes that lead to the formation of OEA. OEA further combines with PPAR‐α to enable fat oxidation in the liver, resulting in enhan...
Source: Obesity Reviews - Category: Eating Disorders & Weight Management Authors: Tags: Behavioral Physiology Source Type: research
(University of Illinois at Chicago) Women at opposite extremes of the weight spectrum have low levels of the neuroactive steroid allopregnanolone, according to new research published in the journal Neuropsychopharmacology.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15) is a divergent transforming growth factor (TGFβ) superfamily cytokine implicated in biological and disease processes including metabolism, cancer, and chronic inflammation, but whose receptor has remained elusive. Four laboratories have recently identified GFRAL, an orphan receptor of the glial-derived neurotrophic factor (GDNF) receptor α family, as the receptor for MIC-1/GDF15, signaling though the coreceptor Ret. These data identify a new systemic to central nervous system (CNS) circuit that regulates metabolism ...
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Tags: Trends Mol Med Source Type: research
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Source: Journal of Neuroendocrinology - Category: Endocrinology Authors: Tags: Original Article Source Type: research
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