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Long ‐term outcome of anorexia nervosa: Results from a large clinical longitudinal study

DiscussionMany patients with very severe AN recover from their illness but AN also shows considerable long‐term negative consequences. Over long time periods, survivors show improvement but better treatments for severe cases are still needed. Predictors of outcome included symptom severity, chronicity, and length of follow‐up but not psychiatric comorbidity.
Source: International Journal of Eating Disorders - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Authors: Gupta S, Ved A Abstract Operculina turpethum (Linn.) (OT) Silva Manso belongs to the family Convolvulaceae. This review incorporates literature for the phytochemical and pharmacological profile of OT herb. Exhaustive literature survey was done using all the details on phytochemistry and pharmacology of OT available. This herb was found to be a potent source of bioactive compounds such as α- and β-turpethein, turpethinic acids (A, B, C, D, and E), coumarins, cycloartenol, lanosta-5-ene, 24-methylene-δ-5-lanosterol, α- and β-rhamnose, β-sitosterol, lupeol, scopoletin, betulin...
Source: Pharmacognosy Reviews - Category: Drugs & Pharmacology Tags: Pharmacogn Rev Source Type: research
This study explores four novel fatty acid modified apelin-13 analogues, namely, (Lys(8)GluPAL)apelin-13 amide, pGlu(Lys(8)GluPAL)apelin-13 amide, Lys(8)GluPAL(Tyr(13))apelin-13 and Lys(8)GluPAL(Val(13))apelin-13. Fatty acid modification extended the half-life of native apelin-13 to>24 h in vitro. pGlu(Lys(8)GluPAL)apelin-13 amide was the most potent insulinotropic analogue in BRIN-BD11 cells and isolated islets with maximal stimulatory effects of up to 2.7-fold (p
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research
Authors: Martín J, Padierna A, Loroño A, Muñoz P, Quintana JM Abstract BACKGROUND: The aims of this study were to analyse the quality of life (QoL) of a broad sample of patients with eating disorders (ED) and to identify potential factors that predict QoL. METHODS: This prospective cohort study involved 528 patients diagnosed with ED and treated over a 15-year period in the Eating Disorders Outpatient Clinic. Information on sociodemographic and clinical data were gathered. Patients completed five self-administered instruments: the Eating Attitudes Test-26 (EAT-26); the Eating Disorder Diagn...
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
This study aimed to quantify PNX expression in the rat heart, and to evaluate whether the peptide influences the myocardial function under basal condition and in the presence of ischemia/reperfusion (I/R). By ELISA the presence of PNX was detected in both hypothalamus and heart. In plasma of normal, but not of obese rats, the peptide concentrations increased after meal. Exposure of the isolated and Langendorff perfused rat heart to exogenous PNX induces a reduction of contractility and relaxation, without effects on coronary pressure and heart rate. As revealed by immunoblotting, these effects were accompanied by an increa...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
Purpose of review: Psychological interventions are the treatment of choice for most eating disorders; however, significant proportions of patients do not recover with these. Advances in understanding of the neurobiology of eating disorders have led to the development of targeted treatments, such as deep brain stimulation (DBS), noninvasive brain stimulation (NIBS), and neurofeedback. We review the emerging clinical evidence for the use of these interventions in eating disorders and obesity, together with their theoretical rationale. Finally, we reflect on future developments. Recent findings: During the last 20 months, se...
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: EATING DISORDERS: Edited by Hans W. Hoek Source Type: research
Conditions:   Appetitive Behavior;   Pediatric Obesity Intervention:   Other: High Intensity Exercise/Ibuprofen Sponsor:   University of Toronto Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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