Reciprocal cooperation of phytochemicals and micronutrients against typical and atypical forms of Borrelia spp

Conclusions: These results show that a specific combination of flavones might play a supporting role in combating Borrelia spp. through either synergistic or additive anti‐borreliae effects. Significance and Impact of Study: Presented here in vitro results might help advancing our knowledge and improving the approach to target Borrelia spp. This article is protected by copyright. All rights reserved.
Source: Journal of Applied Microbiology - Category: Microbiology Authors: Tags: Original Article Source Type: research

Related Links:

In this study, we used PCR-based methods to provide the first evidence of Borrelia burgdorferi sensu lato (s.l.) infections in the three bat-associated tick species collected from ten bat species sampled in Poland and Romania. B. burgdorferi s.l. was detected in 24% (64/266) of tick samples, and 40.3% (60/149) of the bats carried infected chiropterophilic ticks.In Poland, the B. burgdorferi s.l. infection prevelance of I. ariadnae ticks parasitizing Myotis species was four times higher compared to the I. vespertilionis ticks derived from Rhinolophus hipposideros bats (44.4% vs.10%, respectively). The observed differences i...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
A basic feature of infection caused by Borrelia burgdorferi, the etiological agent of Lyme borreliosis, is that persistent infection is the rule in its many hosts. The ability to persist and evade host immune clearance poses a challenge to effective antimicrobial treatment. A link between therapy failure and the presence of persister cells has started to emerge. There is growing experimental evidence that viable but noncultivable spirochetes persist following treatment with several different antimicrobial agents. The current study utilized the mouse model to evaluate if persistence occurs following antimicrobial treatment ...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Bacterial Infections Source Type: research
Authors: Brodziński S, Nasierowski T Abstract In the second part of the article case reports of three patients were presented. All patientswere treated for Borrelia infection and all of them developed psychotic disorders. History of each patient was different, as well as the probability of causal relationship between neuroborreliosis and psychosis. The first case concerns a female patient with no former psychiatric history, who developed psychotic episode secondary to neuroborreliosis. Psychotic disorders resolved after antibiotic treatment. In the second case, a male patient was previously twice hospitalized in p...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Authors: Brodziński S, Nasierowski T Abstract Borreliosis is a multisystem, bacterial, zoonotic infectious disease with diversified spectrumof symptoms, which may also include psychotic disorders. Clinical picture of the disease is often unspecific, which makes the diagnosis relatively difficult. Uncharacteristic process of borreliosis is a result of complex molecular strategies used by spirochetes to infect, disseminate and survive in host organism. Part I of the article is focused on the current knowledge about pathogenesis of Lyme Borreliosis (LB), especially neuroborreliosis. Additionally, epidemic situation i...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
The periplasmic lipoprotein BB0365 of the Lyme disease agentBorrelia burgdorferi is expressed throughout mammalian infection and is essential for all phases of Lyme disease infection; its function, however, remains unknown. In the current study, our structural analysis of BB0365 revealed the same structural fold as that found in the NqrC and RnfG subunits of the NADH:quinone and ferredoxin:NAD+ sodium ‐translocating oxidoreductase complexes, which points to a potential role for BB0365 as a component of the sodium pump. Additionally, BB0365 coordinated Zn2+ by the His51, His55, His140 residues, and the Zn2+‐binding...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Research Article Source Type: research
This article is protected by copyright. All rights reserved.
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Research Articles Source Type: research
The spirochete Borrelia burgdorferi, the causative agent of Lyme disease, is internalized by macrophages and processed in phagolysosomes. Phagosomal compaction, a crucial step in phagolysosome maturation, is driven by contact of Rab5a-positive vesicles with the phagosomal coat. We show that the sorting nexin SNX3 is transported with Rab5a vesicles and that its PX domain enables vesicle–phagosome contact by binding to PI(3)P in the phagosomal coat. Moreover, the C-terminal region of SNX3 recruits galectin-9, a lectin implicated in protein and membrane recycling, which we identify as a further regulator of phagosome co...
Source: Journal of Cell Biology - Category: Cytology Authors: Tags: Trafficking, Immunology Articles Source Type: research
This study was aimed to know epidemiological aspects of Borrelia spp. in a protected urban area of Buenos Aires city, Argentina, where thousands of people visit this area for recreational purposes. Ticks were collected from vegetation, birds and dogs. Three hundred and forty birds belonging to 43 species, 41 genera, 18 families and six orders were captured (90.3% corresponded to the order Passeriformes). One hundred and twenty ticks were collected from 47 birds (13.8%) belonging to 10 species (23.2%), all of them from to the order Passeriformes (Emberizidae, Furnariidae, Parulidae, Thraupidae, Troglodytidae, Turdidae). Tic...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In this study, B. burgdorferi-negative dogs were inoculated with B. turicatae, and seroconversion was confirmed by the rBipA (recombinant Borrelia immunogenic protein A) Western blot. Seropositive samples were tested with commercial and veterinary diagnostic laboratory B. burgdorferi-based tests. Borrelia turicatae-seroreactive samples cross-reacted with a whole-cell indirect fluorescent antibody (IFA) test and two multiantigen tests, but not with single-antigen tests using C6. Cross-reactivity with TBRF can confound epidemiology and surveillance efforts and confuse recommendations made by veterinarians for prevention and ...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Immunoassays Source Type: research
Lyme disease is an infection caused by the spirochete Borrelia burgdorferi after it is transmitted to a mammalian organism during a tick blood meal. B.   burgdorferi encodes at least 140 lipoproteins located on the outer or inner membrane, thus facing the surroundings or the periplasmic space, respectively. However, most of the predicted lipoproteins are of unknown function, and only a few proteins are known to be essential for the persistence and virulence of the pathogen. One such protein is the periplasmic BB0323, which is indispensable for B. burgdorferi to cause Lyme disease and the function of which is associate...
Source: Acta Crystallographica Section D - Category: Biochemistry Authors: Tags: lipoprotein spectrin superfamily cell fission Lyme disease X-ray crystallography Borrelia burgdorferi research papers Source Type: research
More News: Borrelia | International Medicine & Public Health | Lyme Disease | Microbiology | Study