Task-related and resting-state fMRI identify distinct networks that preferentially support remembering the past and imagining the future

Publication date: Available online 15 June 2017 Source:Neuropsychologia Author(s): Adrian W. Gilmore, Steven M. Nelson, Hung-Yu Chen, Kathleen B. McDermott The relation between episodic memory and episodic future thought (EFT) remains an active target of research. A growing literature suggests that similar cognitive processes and neural substrates tend to support these acts. However, direct comparisons of whole-brain activity reveal clear differences, with numerous regions more active when engaging in EFT than when remembering, and a smaller collection of regions displaying the opposite pattern of activity. Although various network labels have been applied to prior neuroimaging results, to date no formal resting-state functional connectivity analysis has been conducted. In the current experiment, 48 subjects remembered events from their past and engaged in EFT. Resting-state data were collected from all subjects. Task results replicated recent findings, with more activity during EFT in regions across frontal and parietal cortex, and with more activity during remembering in a smaller number of predominantly parahippocampal and retrosplenial regions. Resting-state connectivity analysis, based on seed locations defined using the fMRI task data, indicated that regions preferentially activated during EFT fell primarily within the default mode network, while those more active during remembering fell primarily within the contextual association network. These results suggest th...

Source: Neuropsychologia - June 22, 2017 Category: Neurology Source Type: research