The association between in vivo central noradrenaline transporter availability and trait impulsivity

The brain noradrenaline (NA) system, particularly NA transporters (NAT), are thought to play an important role in modulating impulsive behavior. Impaired impulsivity is implicated in a variety of neuropsychiatric conditions; however, an in vivo link between central NAT availability and human impulsivity has not been shown. Using positron emission tomography (PET) and S,S-[11C]O-methylreboxetine (MRB), we tested whether NAT availability is associated with this basic behavioral trait based on the Barratt Impulsiveness Scale (BIS-11) in twenty healthy individuals (12 females, 33.8 ± 9.3, 21–52 years of age) with a body mass index (BMI) ranging from 21.7kg/m2 to 47.8kg/m2.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research