The association between in vivo central noradrenaline transporter availability and trait impulsivity
The brain noradrenaline (NA) system, particularly NA transporters (NAT), are thought to play an important role in modulating impulsive behavior. Impaired impulsivity is implicated in a variety of neuropsychiatric conditions; however, an in vivo link between central NAT availability and human impulsivity has not been shown. Using positron emission tomography (PET) and S,S-[11C]O-methylreboxetine (MRB), we tested whether NAT availability is associated with this basic behavioral trait based on the Barratt Impulsiveness Scale (BIS-11) in twenty healthy individuals (12 females, 33.8 ± 9.3, 21–52 years of age) with a body mass index (BMI) ranging from 21.7kg/m2 to 47.8kg/m2.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Swen Hesse, Ulrich M üller, Michael Rullmann, Julia Luthardt, Anke Bresch, Georg-Alexander Becker, Franziska Zientek, Marianne Patt, Philipp M. Meyer, Matthias Blüher, Maria Strauß, Wiebke Fenske, Mohammed Hankir, Yu-Shin Ding, Anja Hilbert, Osama Sabr Source Type: research