Case report: fast reversal of severe osteoporosis after correction of excessive levothyroxine treatment and long-term follow-up

ConclusionExcessive TSH suppression contributed to the secondary osteoporosis in this patient; BMD normalized after dose reduction of levothyroxine and no fractures occurred during 23 years ’ follow-up. Some patients develop severe osteoporosis if they are over-substituted with levothyroxine, and decent follow-up of patients with levothyroxine supplementation is mandatory.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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Often we don’t really consider gender dynamics in treatment or medication. A lot of medications are only tested on men because of the risk of pregnancy, etc. This means there are whole drugs that have made it to market that may not have ever been tested with women. Schizophrenia affects women in many different ways than men. In this episode schizophrenic Rachel Star Withers and cohost Gabe Howard discuss differences in age, symptoms, treatments, lifestyle, parenthood in the genders as they experience schizophrenia. Dr. Hayden Finch joins to explain the medical side.  Highlights in “Schizophrenia in Women...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Mental Health and Wellness Women's Issues Gender Differences Mental Disorder Mental Illness Psychiatry Psychology Psychotherapy Women's Health women's mental health Source Type: blogs
Regular brushing and flossing are the cornerstones of good oral health. But what if you learned that your toothpaste was good for your teeth, but bad for your bones? That possibility has been raised by a recent study. The cause of this unprecedented finding may be triclosan, an antibacterial agent added to toothpaste to reduce gum infections and improve oral health. However, it may actually be causing more harm than good. Rethinking a popular germ killer Triclosan is an antibacterial agent that’s been around for decades. Not only has it been used in soaps, hand sanitizers, and deodorants, but it’s found its way...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Dental Health Osteoporosis Source Type: blogs
(The North American Menopause Society (NAMS)) Lumbar disc degeneration and resulting lower back pain become greater concerns with age and disproportionately affect women more than men, likely as a result of decreasing estrogen levels during menopause. A new study demonstrates that vitamin D deficiency, smoking, high body mass index (BMI), and osteoporosis are risk factors for greater back pain. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Worldwide, it is estimated about 1.3 million new gynecological cancer cases are diagnosed each year. For 2018 the predicted annual totals were cervix uteri 569,847, corpus uteri 382,069, ovary 295,414, vulva 44,235 and va ​gina 17,600 [1].
Source: Maturitas - Category: Primary Care Authors: Source Type: research
The menopause transition can have a significant impact on many women, with more than 75% experiencing menopausal symptoms, and a quarter describing severe symptoms. Symptoms on average last 7 years and a third of women experience long-term symptoms. Menopausal hormone therapy (MHT), compared with placebo, has consistently shown improvements in menopausal symptoms and overall quality of life. Furthermore, MHT has a significant protective effect against osteoporosis and cardiovascular disease in women initiating MHT under the age of 60 [1,2].
Source: Maturitas - Category: Primary Care Authors: Source Type: research
CONCLUSION: This work highlights differences between muscles of osteoporotic and osteoarthritic subjects that can be quantified by NMR DTI investigations. PMID: 32026431 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Tags: Aging Clin Exp Res Source Type: research
ABSTRACTWe investigated mechanisms resulting in low bone mineral density (BMD) and susceptibility to fracture by comparing non ‐coding RNAs (ncRNAs) in biopsies of non‐weight‐bearing (NWB) iliac (n = 84) and weight bearing (WB) femoral (n = 18) postmenopausal bone across BMDs varying from normal (T‐score >  −1.0) to osteoporotic (T‐score ≤ −2.5). Global bone ncRNA concentrations were determined by PCR and microchip analyses. Association with BMD or fracture, adjusted by age and body mass index, were calculated using linear and logistic regression a...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
ni Dallolio Osteoporosis (OP) is a systemic disease of the skeleton characterized by increased risk of fracture. There is a general consensus on the efficacy of physical activity in the prevention of bone loss, falls and fractures, but there is no agreement on the best setting to exercise. The aim of the study is to evaluate the efficacy of a 12-months exercise protocol for women with post-menopausal OP when administered as individual home training (IHT) versus gym group training (GGT). The study is a randomized trial with two parallel groups. Sedentary patients with primary post-menopausal osteoporosis are recruite...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Protocol Source Type: research
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