Impact of acute hypertension transients on diastolic function in patients with heart failure with preserved ejection fraction

ConclusionAcute chamber stiffening is the main mechanism responsible for rising late-diastolic pressures when HFpEF patients undergo hypertension transients. This stiffening behaviour is related to impaired dynamic systolic –diastolic interactions and correlates with matrix remodelling. Ventricular-vascular relationships are a promising target in HFpEF and should be taken into account when assessing diastolic function.
Source: Cardiovascular Research - Category: Cardiology Source Type: research