Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis.
Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis. Biochimie. 2017 Jun 16;: Authors: Brown CR, Dennis EA Abstract Experimental Lyme arthritis provides a mouse model for exploring the development of pathology following infection of C3H mice with Borrelia burgdorferi. Infected mice develop a reliable inflammatory arthritis of the ankle joint with severity that typically peaks around two to three weeks post-infection and then undergoes spontaneous resolution. This makes experimental Lyme arthritis an excellent model for investigating the mechanisms that drive both the development and resolution phases of inflammatory disease. Eicosanoids are powerful lipid mediators of inflammation and are known to regulate multiple aspects of inflammatory processes. While much is known about the role of eicosanoids in regulating immune responses during autoimmune disease and cancer, relatively little is known about their role during bacterial infection. In this review, we discuss the role of eicosanoid biosynthetic pathways in mediating inflammatory responses during bacterial infection using experimental Lyme arthritis as a model system. We point out the critical role eicosanoids play in disease development and highlight surprising differences between sterile autoimmune responses and those occurring in response to bacterial infection. These differences should be kept in mind when designing therapies and treatments for inflammatory disea...
CONCLUSIONS: The COI of liver diseases in Japan has been decreasing for the past 15 years. In the future, a further reduction in patients with hepatitis C is expected, and even if the incidence of NASH and alcoholic liver disease increases, that of cirrhosis and liver cancer will likely continue to decrease. PMID: 32942026 [PubMed - as supplied by publisher]
CONCLUSION: We determined etiologies in 86.3% of children with non-CAH PAI through specific clinical and laboratory findings with/without molecular analysis of candidate genes. ALD was the most common etiology. Nowadays, advanced molecular analyse can be utilized to establish a specific genetic diagnosis of PAI for patients who have no specific diagnostic features. PMID: 32938577 [PubMed - as supplied by publisher]
Publication date: December 2020Source: Nano Today, Volume 35Author(s): Tanziela Tanziela, Sana Shaikh, Hui Jiang, Zuhong Lu, Xuemei Wang
Publication date: November–December 2020Source: Journal of Materials Research and Technology, Volume 9, Issue 6Author(s): Reza Eivazzadeh-Keihan, Fateme Radinekiyan, Somayeh Asgharnasl, Ali Maleki, Hossein Bahreinizad
Authors: Schipani G, Del Duca E, Todaro G, Scali E, Dastoli S, Bennardo L, Bonacci S, Di Raimondo C, Pavel AB, Colica C, Xu X, Procopio A, Patruno C, Nisticó SP Abstract BACKGROUND: The role of heavy metals in carcinogenetic process has been widely established however, information on the most common environmental metals that serve as major risk factors for actinic keratosis (AK)/non-melanoma skin cancer (NMSC) are still lacking. We aim to evaluate levels of the most common environmental heavy metals in hair of patients with AK/NMSC as compared to healthy controls. METHODS: 31 patients diagnosed with AK/N...
CONCLUSIONS: In our study we have confirmed the utility of ultrasound in the diagnosis of BCCs and for the first time we have correlated ultrasounds' patterns with dermoscopy and tumor thickness. PMID: 32938160 [PubMed - as supplied by publisher]
Abstract Ankle arthrodesis continues to be the golden standard in the treatment of end-stage ankle arthritis. Meticulous soft tissue handling, correct positioning of the foot, and stable fixation are crucial for obtaining a favorable result. With current techniques, mostly internal fixation with screws or plates, union rates between 87 and 100% are reported. Adjacent joint arthritis remains a concern in long-term follow-up, but does not always become symptomatic. It is pre-existing in a substantial number of cases and associated with fusion in less than optimal position, particularly equinus. With arthroscopic art...
Publication date: Available online 18 September 2020Source: Biosensors and BioelectronicsAuthor(s): Shahrzad Forouzanfar, Fahmida Alam, Nezih Pala, Chunlei Wang
Publication date: Available online 17 September 2020Source: Biosensors and BioelectronicsAuthor(s): Junyue Chen, Tingting Fan, Yan Chen, Lizhen Ye, Chen Zhang, Feng Liu, Ying Qin, Ying Tan, Yuyang Jiang
Publication date: Available online 18 September 2020Source: Journal of Molecular BiologyAuthor(s): Mélanie Kirchmeyer, Florence Servais, Aurélien Ginolhac, Petr V. Nazarov, Christiane Margue, Demetra Philippidou, Nathalie Nicot, Iris Behrmann, Claude Haan, Stephanie Kreis