Clinical Picture Neisseria meningitidis subdural empyema causing acute cauda equina syndrome
A 22-year-old man presented to a hospital emergency department with symptoms of bacterial meningitis but without focal neurology. Blood and CSF cultures were positive for Neisseria meningitidis serogroup B. He received empirical bacterial meningitis therapy on presentation to the hospital as per local guidelines with 4 g ceftriaxone every 24 h, vancomycin titrated to>20 mg/L and 10 mg dexamethasone every 6 h, and 1 ·8 g benzylpenicillin every 4 h. On day 2 after admission, after bacterial identification of N meningitidis, treatment was simplified to the use of high dose ceftriaxone monotherapy.
The translocation of bacteria across the intestinal epithelium of immunocompromised patients can lead to bacteremia and life-threatening sepsis. Extraintestinal pathogenic Escherichia coli (ExPEC), so named because this pathotype infects tissues distal to the intestinal tract, is a frequent cause of such infections, is often multidrug resistant, and chronically colonizes a sizable portion of the healthy population. Although several virulence factors and their roles in pathogenesis are well described for ExPEC strains that cause urinary tract infections and meningitis, they have not been linked to translocation through inte...
CONCLUSION: This report discusses the possible underlying etiologies for the bilateral caudate infarcts and necrosed flaps including bacterial meningitis with associated local vasospasm of nearby vessels resulting in infarction. This case emphasizes the importance of concise management of postendoscopic CSF leak and discusses the guidelines regarding antimicrobial therapy and the management of lumbar drains. PMID: 29026671 [PubMed]
CONCLUSION: The findings of this study suggest that IVT and IT antibiotic therapy is a useful option in patients who are nonresponsive to standard intravenous therapy with little or no side effects. PMID: 29026662 [PubMed]
We report a case of Avitene-induced granulomatous inflammation presenting as meningitis after neurosurgery for WHO grade II atypical meningioma.
Authors: Oda R, Sekikawa Y, Hongo I PMID: 29021440 [PubMed - as supplied by publisher]
Background: Borrelia burgdorferi is a common cause of bacterial meningitis, but there are very few studies on incidence in Europe. The aim of this study was to report the incidence and symptoms of neuroborreliosis in Swedish children. Methods: Medical records of children (
Conclusions: All the E. coli isolates responsible for this outbreak belonged to a single clone suggesting a common source of infection, and it was categorized as O18:K1:H7. Despite the bacteria’s pathogenicity has an important role in the severity of infection, the host-associated factors were crucial for the fatal outcomes.
Conclusions: One incident EOI of asthma late in the 1-year observation period and sporadic distribution of SMAEs were observed. These data do not suggest safety concerns associated with MenACWY-CRM vaccination in children 2–10 years old.
We ’ re working closely with Public Health England (PHE) following the confirmed diagnosis of bacterial meningitis (Meningococcal B) in one of our students yesterday.
Authors: Delgado Rodríguez M, Domínguez García Á Abstract A vaccine has recently been approved in the EU against meningococcal serogroup B, the main cause of meningococcal disease. There is a fierce debate about the decision regarding a universal vaccination in infants older than 2 months, as recommended by the majority of scientific societies. In western Europe the only country to have included the universal vaccination is the United Kingdom, with a lower incidence of the disease than Ireland. Other countries have also adopted it, such as the Czech Republic, Cuba and certain regions of ...