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Newsdesk Research brief

US scientists have created a vancomycin analogue they think will push back the threat of antibiotic resistance. The analogue, made by researchers at The Scripps Research Institute in La Jolla, CA, USA, has three independent modes of action on bacterial cell wall synthesis or maintenance. It has proved effective against vancomycin-resistant strains of both enterococci and Staphylococcus aureus in vitro, which showed no resistance after 50 rounds of testing. The findings are preliminary, with the 30-step manufacturing process needing to be simplified before testing in animals and people.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Newsdesk Source Type: research

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This study for the first time suggests that the chemical compounds present in the acetone extract of B. setschwanensis could be used against S. aureus and C. neoformans infections. Graphical abstract
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Conclusion Although, mecA resistant genes were found only among clinical MRSA, the occurrence of other bi-component leukocidin genes in a large proportion among the isolates from both community and clinical settings is a major concern. The need for effective resistance and virulence factor surveillance, re-enforcement of antibiotic stewardship and good infection control policy, to prevent dissemination of epidemic strains is highlighted.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: January 2018 Source:Microbial Pathogenesis, Volume 114 Author(s): Rajagopalan Thaya, Baskaralingam Vaseeharan, Jeyachandran Sivakamavalli, Arokiadhas Iswarya, Marimuthu Govindarajan, Naiyf S. Alharbi, Shine Kadaikunnan, Mohammed N. Al-anbr, Jamal M. Khaled, Giovanni Benelli The successful treatment of multi-drug resistant microbial pathogens represents a major challenge for public health management. Here, chitosan-alginate (CS/ALG) microspheres with narrow size distribution were fabricated by ionically cross linking method using Ca2+ ions as agents for polymer solidification. The physicochemical properti...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: January 2018 Source:Microbial Pathogenesis, Volume 114 Author(s): Marcus Vinícius Dias-Souza, Renan Martins dos Santos, Isabela Penna Cerávolo, Gustavo Cosenza, Pedro Henrique Ferreira Marçal, Flávio Jr Barbosa Figueiredo Euterpe oleracea (Açaí) fruit are widely consumed at the Brazilian Amazon region, and biological potentials such as immunomodulatory and antioxidant have been described for its extracts. However, its antimicrobial properties remain poorly investigated. Here, the antimicrobial and antibiofilm activities of the methanolic extract of an artisanally...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: January 2018 Source:Microbial Pathogenesis, Volume 114 Author(s): Arivalagan Pugazhendhi, Desika Prabakar, Jaya Mary Jacob, Indira Karuppusamy, Rijuta Ganesh Saratale Microfouling is evolving at a fast rate causing augmented mortality rates and damage worldwide. Until now, several remedial measures have been exploited to overcome microfouling, amongst them nanoparticles play a superior role. Currently, green synthesized nanoparticles have been centered owing to its eco-friendly, cost effectively and non-toxic nature which has also increased its industrial applications (biomedicine, food and textile). In ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 14 December 2017 Source:Microbial Pathogenesis Author(s): Rajan Abraham, Prakash Periakaruppan, Karthikeyan Mahendran, Murugappan Ramanathan A novel N-acyl substituted indole-linked benzimidazoles and naphthoimidazoles were synthesized. Their chemical structures were confirmed using spectroscopic tools including 1H NMR, 13C NMR and CHN-elemental analyses. Anti inflammatory activity for all target compounds was evaluated in-vitro. The synthesized compounds hinder the biofilm formation and control the growth of the pathogen, Staphylococcus epidermis. Anti microbial activity of the compound...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 9 December 2017 Source:Microbial Pathogenesis Author(s): Ali Mohd Lone, Muneer Ahmad Bhat, Muzafar Ahmad Rather, Wajaht Amin Shah, Zubair Shanib Bhat, Irfan Qadir Tantry, Poonam Prakash The study was designed with an aim to synthesize a series of 2-(((2-ether)amino)methylene)-dimedone derivatives and evaluate the synthesized compounds for antimicrobial activity. Compound library was synthesized by reaction with alkyl, alkenyl, alkynyl and alicyclic bromo-compounds. Characterization of the synthesized compounds was performed by 1H NMR, 13C NMR and mass spectral techniques. The compounds w...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 8 December 2017 Source:Microbial Pathogenesis Author(s): D. MubarakAli, F. LewisOscar, V. Gopinath, Naify S. Alharbi, Sulaiman Ali Alharbi, N. Thajuddin Chitosan is the second most abundant polymer obtained from the byproduct of seafood. Chitosan and its derivatives and chitosan loaded drugs are the recent area of interest against microbial pathogenesis. The cationic chitosan nanoparticles (ChNPs) interact with the anionic surfaces of the microbial cell membrane, which promotes antimicrobial activity. Although, ChNPs are potential against pathogenic microbes, selection of adaptable, suit...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: 15 March 2018 Source:Materials Letters, Volume 215 Author(s): Guangda Li, Nan Zhang, Santuan Zhao, Kaili Zhang, Xiaoyu Li, Aihua Jing, Xinping Liu, Tian Zhang In present research, Fe-doped brushite bone cements were synthesized. The setting time, microstructure and antibacterial property of samples were investigated. The results showed that the setting time of cements was retarded to about 20 min and 123 min, respectively, as iron doping content increasing from 1 mol% to 5 mol% in β-TCP powder. Moreover, Fe-doped cements had much bigger crystal particles and calcium iron phosphate was identi...
Source: Materials Letters - Category: Materials Science Source Type: research
Conclusions Colonizing strains showed a virulence profile in all age groups which can potentially lead to the establishment of an invasive infection. Consequently, decolonization measures could be considered for selected patients depending on the risk of infection.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
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