Newsdesk Research brief
US scientists have created a vancomycin analogue they think will push back the threat of antibiotic resistance. The analogue, made by researchers at The Scripps Research Institute in La Jolla, CA, USA, has three independent modes of action on bacterial cell wall synthesis or maintenance. It has proved effective against vancomycin-resistant strains of both enterococci and Staphylococcus aureus in vitro, which showed no resistance after 50 rounds of testing. The findings are preliminary, with the 30-step manufacturing process needing to be simplified before testing in animals and people.
CONCLUSIONS: We have documented the common clinical and echocardiographic characteristics of patients with IE secondary to IV nyaope use. IE due to IV drug use is responsible for considerable morbidity and mortality in a predominantly young male population. PMID: 30004347 [PubMed - in process]
CONCLUSIONS: Almost half of the theatre staff carried S. aureus isolates on their hands prior to handwashing and approximately one-third after handwashing. Closer monitoring of handwashing techniques should be introduced. PMID: 30004326 [PubMed - in process]
ConclusionsThe pernicious effect of high vancomycin MIC disappears in the absence of a predominant use of this antibiotic. However, a high daptomycin MIC in MRSA bacteraemia is associated with higher mortality in patients with bacteraemia, irrespective of antimicrobial treatment choice.
Publication date: Available online 11 May 2018Source: Materials Chemistry and PhysicsAuthor(s): Emilia Zachanowicz, Jacek Pigłowski, Aleksander Zięcina, Krzysztof Rogacki, Błażej Poźniak, Marta Tikhomirov, Monika Marędziak, Krzysztof Marycz, Joanna Kisała, Kinga Hęclik, Robert PązikAbstractPolymeric hybrid materials were synthesized via chemical oxidation polymerization. Process was carried on the surface of the magnetic nanoparticles, (prepared separately) where the initiator (Fe3+ ions) was located. The structure of the resulting nanocomposite was investigated in detail by means of X-ray diffraction (XRD) and Fo...
Conclusions: Delayed cerebral injury occurred in 4.1% of adults with bacterial meningitis, and it was associated with the use of adjunctive steroids. Future studies should explore the etiology and prevention of this devastating complication.
ConclusionThe large variety of cultivable, clinically important bacteria, especially the genetically related MDR S. aureus, K. pneumoniae, Acinetobacter spp. and Enterobacter spp., from various sampling sites indicated that the surfaces and fomites in the hospital were potential exogenous sources of nosocomial infection in the hospital.
Authors: Tang X, Xiao M, Zhuo C, Xu Y, Zhong N Abstract Background: With the different situation for clinical antibiotic usage and its management in different regions and medical institutions, the antimicrobial resistance varied in different level. However, the epidemiological data of multi-drug resistant (MDR) strains from the department of respiration is limited. Thus, this study aims to investigate the epidemiology of bacteria isolated from inpatients of respiratory departments, and analyze the distribution variation of major multi-drug resistant bacteria in China. Methods: Based on data from China Antimicro...
Toma Keser Branka Zorc Novel primaquine (PQ) and halogenaniline asymmetric fumardiamides 4a–f, potential Michael acceptors, and their reduced analogues succindiamides 5a–f were prepared by simple three-step reactions: coupling reaction between PQ and mono-ethyl fumarate (1a) or mono-methyl succinate (1b), hydrolysis of PQ-dicarboxylic acid mono-ester conjugates 2a,b to corresponding acids 3a,b, and a coupling reaction with halogenanilines. 1-[bis(Dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU) was used as a coupling reagent along with Hüni...
Conclusion: Sperm bacterial contamination is quite frequent and could contribute to the deterioration of the sperm quality of infertile males. PMID: 29997751 [PubMed]
Conclusion: Our results revealed that ST clones associated with healthcare-associated MRSA (HA-MRSA) are actively circulating among nasal carriage in our healthcare setting, and thus, effective infection control policies are needed to reduce nasal carriage in healthcare settings. PMID: 29997747 [PubMed]