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Newsdesk Research brief

US scientists have created a vancomycin analogue they think will push back the threat of antibiotic resistance. The analogue, made by researchers at The Scripps Research Institute in La Jolla, CA, USA, has three independent modes of action on bacterial cell wall synthesis or maintenance. It has proved effective against vancomycin-resistant strains of both enterococci and Staphylococcus aureus in vitro, which showed no resistance after 50 rounds of testing. The findings are preliminary, with the 30-step manufacturing process needing to be simplified before testing in animals and people.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Newsdesk Source Type: research

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Publication date: 15 February 2018 Source:Journal of Molecular Structure, Volume 1154 Author(s): Hussain Gulab, Zarbad Shah, Mazhar Mahmood, Syed Raza Shah, Sajid Ali, Muhammad Iqbal, Muhammad Naeem Khan, Ulrich Flörke, Shahid Ali Khan A new Ca-complex (Ca (H2 O)4 (C12 H8 N2)2)(C7 H4 N S2)2 has been synthesized by the reaction of calcium chloride, sodium 2-mercaptobenzothiazole and 1,10-phenanthroline. The complex was characterized by using X-ray crystallography and FT-IR spectroscopy. The complex was tested against different bacterial strains i.e. Staphylococcus aureus, Escherichia coli, Acinetobacter baumanni, Prov...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
BackgroundThe aim of this paper was to retrospectively review non‐lactation breast abscesses treated in Princess Alexandra Hospital over a 10‐year period and to illustrate the trends in size, risk factors, microbiological profile and management. MethodsA computerized search of the medical records was undertaken to identify all adult patients with a diagnosis of breast abscesses during June 2005–June 2015. Patients concurrently breastfeeding were excluded. A retrospectively review of the clinical records was performed. ResultsEighty‐five abscesses were identified in 77 patients. The median patient age was 45&thi...
Source: ANZ Journal of Surgery - Category: Surgery Authors: Tags: Original Article Source Type: research
This study addresses the improvement of meat microbial quality by enriching the diet of farm animals with a protective culture. Weaned Grimaud rabbits were divided into two experimental groups: a control and a diet supplemented with Micocin® (Carnobacterium maltaromaticum CB1; 8Log10 CFU/kg of feed). Overall, meat quality was not affected substantially by the treatment. Total Aerobic Mesophilic (TAM), Escherichia coli and other coliforms, Enterobacteriaceae, Staphylococcus aureus, Pseudomonas spp., Listeria spp. and presumptive lactic acid bacteria counts were evaluated on whole thighs stored under aerobic (0, 3, 6, 8d...
Source: Meat Science - Category: Food Science Source Type: research
Publication date: 1 February 2018 Source:Materials Letters, Volume 212 Author(s): Ivana Malagurski, Steva Levic, Miodrag Mitric, Vladimir Pavlovic, Suzana Dimitrijevic-Brankovic Two bimetallic (Zn/Cu) alginate based nanocomposites, impregnated with carbonate or phosphate mineral phase, were prepared by a facile procedure. Mineralized samples exhibited different morphologies and properties when compared to the non-mineralized sample. Antimicrobial testing against Escherichia coli, Staphylococcus aureus and Candida albicans showed that mineralized samples are more efficient than non-mineralized in elimination of microorgani...
Source: Materials Letters - Category: Materials Science Source Type: research
Staphylococcus aureus is a human commensal but also has devastating potential as an opportunistic pathogen. S. aureus bacteremia is often associated with an adverse outcome. To identify potential targets for novel control approaches, we have identified S. aureus components that are required for growth in human blood. An ordered transposon mutant library was screened, and 9 genes involved specifically in hemolysis or growth on human blood agar were identified by comparing the mutants to the parental strain. Three genes (purA, purB, and pabA) were subsequently found to be required for pathogenesis in the zebrafish embryo inf...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Bacterial Infections Source Type: research
Publication date: 15 February 2018 Source:Journal of Molecular Structure, Volume 1154 Author(s): Raghavendra P. Bakale, Ganesh N. Naik, Shrinath S. Machakanur, Chandrashekhar V. Mangannavar, Iranna S. Muchchandi, Kalagouda B. Gudasi A hydrazone ligand has been synthesized by the condensation of 2-nitrobenzaldehyde and hydralazine, and its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been reported. Structural characterization of the ligand and its metal complexes has been performed by various spectroscopic [IR, NMR, UV–Vis, Mass], thermal and other physicochemical methods. The structure of the ligand and its Ni(I...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Microbial Drug Resistance , Vol. 0, No. 0.
Source: Microbial Drug Resistance - Category: Microbiology Authors: Source Type: research
Conclusions The incidence of VAP, CAUTI, and CLABSI were high in ICUs, and multi-drug resistant organisms were the primary pathogens of NI. The implementation of targeted surveillance can determine the risk factors of NI so that effective intervention measures can be taken to reduce the incidence of NI in ICUs patients.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
The type VII secretion system (T7SS) of Staphylococcus aureus is a multiprotein complex dedicated to the export of several virulence factors during host infection. This virulence pathway plays a key role in promoting bacterial survival and the long-term persistence of staphylococcal abscess communities. The expression of the T7SS is activated...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Author Affiliations open 1Public Health Institute, Oakland, California, USA 2Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA 3Instituto de Microbiologia, Colegio de Ciencias Biologicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador 4Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, USA 5Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA 6Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA PDF Version (176 KB) Abstract ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Brief Communication Source Type: research
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