Newsdesk Research brief
US scientists have created a vancomycin analogue they think will push back the threat of antibiotic resistance. The analogue, made by researchers at The Scripps Research Institute in La Jolla, CA, USA, has three independent modes of action on bacterial cell wall synthesis or maintenance. It has proved effective against vancomycin-resistant strains of both enterococci and Staphylococcus aureus in vitro, which showed no resistance after 50 rounds of testing. The findings are preliminary, with the 30-step manufacturing process needing to be simplified before testing in animals and people.