Correspondence 23-valent pneumococcal polysaccharide vaccine against pneumococcal pneumonia

Motoi Suzuki and colleagues1 found that 23-valent pneumococcal polysaccharide vaccine (PPV23) showed low to moderate effectiveness against vaccine serotype pneumococcal pneumonia in Japanese people aged 65 years or older treated at four community-based hospitals from September, 2011, to August, 2014. As the authors wrote, 7-valent pneumococcal conjugate vaccine (PCV7) became commercially available for Japanese children in February, 2010, and it was incorporated into the routine immunisation schedule for children in April, 2013.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research

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A pilot protocol developed at Memorial Sloan Kettering Cancer Center resulted in exponential increases in both influenza and pneumococcal vaccinations in the outpatient setting.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
This study examined the relationship between resident race and immunization status in long-term care facilities (LTCFs). Race was captured at the resident and the facility racial composition level.DesignThirty-six long-term care facilities varying in racial composition and size were selected for site visits.SettingLTCFs were urban and rural, CMS certified, and non-hospital administered.MeasurementsChart abstraction was used to determine race, immunization, and refusal status for the 2010 –2011 flu season (influenza 1), the 2011–2012 flu season (influenza 2), and the pneumococcal pneumonia vaccine for all reside...
Source: Journal of Racial and Ethnic Health Disparities - Category: International Medicine & Public Health Source Type: research
In this study, we describe a simple method to produce PspA of clade 4 from an Escherichia coli expression system using hydroxylapatite and ion-exchange chromatography. Using this method, we successfully expressed soluble PspA4 in 10 L of autoinducing culture medium, with a wet-cell yield of 19 g/L and a final PspA4 concentration of 22.8 mg/L. Additionally, we improved PspA4 purity from 17% to 70% in a single step through the use of hydroxylapatite, resulting in acquisition of recombinant PspA4 (>95% purity) at a final yield of 43% from the starting cell-lysis solution. We subsequently verified the secondary struct...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: June–July 2018Source: Revista Clínica Española (English Edition), Volume 218, Issue 5Author(s): A.R. Domínguez-Alegría, V. Pintado, I. BarbollaAbstractInvasive pneumococcal disease is a severe infection that mainly affects patients with associated comorbidity. The pediatric conjugate vaccination has resulted in a change in the adult vaccination strategy. The antibiotic resistance of pneumococcus is not currently a severe problem. Nevertheless, the World Health Organisation has included pneumococcus among the bacteria whose treatment requires the introduction of new drugs,...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Publication date: July 2018Source: The Lancet Global Health, Volume 6, Issue 7Author(s): Brian Wahl, Katherine L O'Brien, Adena Greenbaum, Anwesha Majumder, Li Liu, Yue Chu, Ivana Lukšić, Harish Nair, David A McAllister, Harry Campbell, Igor Rudan, Robert Black, Maria Deloria KnollSummaryBackgroundPneumococcal conjugate vaccine (PCV) and Haemophilus influenzae type b (Hib) vaccine are now used in most countries. To monitor global and regional progress towards improving child health and to inform national policies for disease prevention and treatment, we prepared global, regional, and national disease burden estimat...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
ConclusionsSputum gram staining, sputum culture tests, and other bacteriological tests were implemented quite actively. However, physicians who treat aspiration pneumonia should implement efforts to prevent pneumonia recurrence more actively.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
We present two adult cases of pneumococcal severe arthritis one case with, and other case without pericarditis those occurred in one season. Both cases eventually recovered, and the isolated S. pneumoniae strains were serotype 12F and penicillin susceptible. The patients were not elderly and had no medical history including pneumonia and vaccination. Although S. pneumoniae is a relatively rare causative pathogen of arthritis and/or pericarditis recently, a greater number of cases may be expected as a result of serotype conversion due to the increased use of pneumococcal conjugate vaccines in Japan.
Source: IDCases - Category: Infectious Diseases Source Type: research
ConclusionTaken together, our results suggest that KRG reduces the time required for immunization with the Δpep27 vaccine by enhancing its efficacy.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
ConclusionSerotype data from this study helped in accurate estimation of pneumococcal conjugate vaccine-13 and pneumococcal polysaccharide vaccine-23 protective coverage against serotypes causing IPD in India as 58.7% (95% CI: 53.8, 63.4) and 67.4% (95% CI: 62.7, 71.8) respectively. Penicillin non-susceptibility in meningeal IPD cases is 27.4%. Empirical therapy for meningeal IPD must be cephalosporin in combination with vancomycin since cefotaxime non-susceptibility in meningeal IPD is 9.9%
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
This study was conducted to identify risk factors and different 13-valent pneumococcal conjugate vaccine (PCV13) schedules associated with vaccine-type invasive pneumococcal pneumonia (IPP) despite prior vaccination.MethodsA case–control study was conducted prospectively between August 2012 and December 2015 at five participating medical centers. The study enrolled children
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
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