Correspondence Fighting drug-resistant tuberculosis in eastern Europe
We read with great interest the letter from Tomasz Jagielsi and colleagues1 presenting the Fight Against TB in Central and Eastern Europe (FATE). As the authors point out, eastern Europe is a hotspot for drug-resistant tuberculosis involving countries both within and outside the EU. The correspondence rightly highlights the need for intercountry and regional collaboration; however, it does not mention the existing regional initiatives and networks including WHO's European TB Laboratory Initiative (ELI),2 the Regional Collaborating Committee on TB,3 the European Centers for Disease Prevention and Control (ECDC) networks,4 and professional societies, among others.
[New Era] Windhoek -A recent study titled 'Optimizing the safety of multidrug-resistant (MDR) tuberculosis therapy in Namibia', by Evans Sagwa, showed that side effects occur frequently in patients treated with current second-line anti-TB drugs.
[Daily Maverick] The start of 2017 saw concern over a sharp increase in the rise of drug- resistant TB in South Africa. TB is killing millions each year. Last week, M édecins Sans Frontières published promising early data on the use of two new TB drugs, delamanid and bedaquiline, among patients living with drug-resistant TB in Khayelitsha, Cape Town. But availability remains the biggest concern.
CONCLUSIONS: The high levels of risky drinking among chronic care patients, particularly among patients receiving treatment for HIV and TB, are concerning. Instituting appropriate screening measures and referral to treatment would be an important first step in mitigating the effects of risky alcohol use among chronic care patients. PMID: 29025457 [PubMed - in process]
(DOE/Oak Ridge National Laboratory) Scientists at the Department of Energy's Oak Ridge National Laboratory have performed neutron structural analysis of a vitamin B6-dependent protein, potentially opening avenues for new antibiotics and drugs to battle diseases such as drug-resistant tuberculosis, malaria and diabetes. Specifically, the team used neutron crystallography to study the location of hydrogen atoms in aspartate aminotransferase, or AAT, an enzyme vital to the metabolism of certain amino acids.
Abstract Arginine biosynthesis pathway is crucial to the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). Arginine is a critical amino acid that contributes to the inflection of cellular immune responses during pathogenesis. Argininosuccinate lyase from Mtb (MtArgH), the last enzyme in the pathway, catalyzes the production of arginine from argininosuccinic acid. MtArgH is an essential enzyme for the growth and survival of M. tuberculosis. We biochemically characterized MtArgH and deciphered the role of a previously unexplored cysteine (Cys441) residue at the C‐terminal region of the protein. Chemical modifi...
Authors: Maltezou HC, Elhadad D, Glikman D Abstract INTRODUCTION: The past decade the Middle East and Southeastern Europe have witnessed an enormous movement of refugees due to the Syrian war and conflicts in Asia and Africa. Although carriage of and infections with multi-drug resistant (MDR) pathogens in refugees have been reported, pediatric data are scarce. Areas covered: MDR bacterial carriage and infections, and MDR-tuberculosis (TB) in refugee children from 2010. Expert commentary: High MDR carriage rates in refugee children are attributed to high pre-civil war MDR rates, war-damaged infrastructure and health...
Conclusions: children with TB represent a large proportion of the pool of undetected TB. A simple TB active case-finding program targeted to high risk groups like children households of severely ill admitted patients with TB can successfully be implemented in a country with limited resources.
CONCLUSIONS: Despite differences in baseline characteristics including cardiovascular risk factors, mortality rates on follow-up were similar in men and women in this study. However, these different baseline characteristics probably suggest differences in the pathogenesis of PH in men and women in our setting that need further investigation. PMID: 29022535 [PubMed - in process]
CONCLUSIONS: This prospective study provides real-life data on thrombosis diagnosis and management at a quaternary public healthcare facility, providing a valuable baseline against which the effect of new DOAC anticoagulants can be assessed. Further research is required to clarify the aetiological association between thrombosis and HIV and TB. PMID: 29022529 [PubMed - in process]
CONCLUSION: GeneXpert MTB/RIF is an accurate test for the detection of TB in tissue samples of HIV-infected and HIV-uninfected patients with suspected musculoskeletal TB. A positive GeneXpert MTB/RIF result should be regarded as microbiological confirmation of TB. PMID: 29022528 [PubMed - in process]