Correspondence Fighting drug-resistant tuberculosis in eastern Europe

We read with great interest the letter from Tomasz Jagielsi and colleagues1 presenting the Fight Against TB in Central and Eastern Europe (FATE). As the authors point out, eastern Europe is a hotspot for drug-resistant tuberculosis involving countries both within and outside the EU. The correspondence rightly highlights the need for intercountry and regional collaboration; however, it does not mention the existing regional initiatives and networks including WHO's European TB Laboratory Initiative (ELI),2 the Regional Collaborating Committee on TB,3 the European Centers for Disease Prevention and Control (ECDC) networks,4 and professional societies, among others.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research

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Abstract Drug resistance is still the major threat to global tuberculosis (TB) control, and drug-resistant (DR) Mycobacterium tuberculosis (M. tuberculosis) strains have become the main challenge worldwide. Currently used antibiotics for treatment of DR-TB are often poorly tolerated and not sufficiently effective. Since the therapeutic options are still limited, the main strategy for treatment of DR-TB is to repurpose existing anti-mycobacterial agents. Clofazimine (CFZ) is one such drug that has recently attracted interest against DR-TB. CFZ is a hydrophobic riminophenazine that was initially synthesized as an an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
This study sought to evaluate the levels of total serum cholesterol in the host following exposure to MAP. Blood samples were collected from both sheep and cattle prior to experimental challenge with MAP and at monthly intervals post-challenge. Total serum cholesterol levels in sheep challenged with MAP were significantly elevated at 9 weeks post-inoculation (wpi) in comparison to controls. When stratified based on disease outcome, there was no significant difference in serum cholesterol at the timepoints examined between MAP exposed sheep that were susceptible and those that were resistant to Johne’s disease. There ...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Publication date: Available online 20 July 2018Source: Journal of Microbiological MethodsAuthor(s): Carlos German Lemus-Minor, Diego Fernando Ovalle-Marroqui, J. Gustavo Vazquez-Jimenez, Diana Laura Reales-Agüero, Perla Michelle Sepulveda-Alcantara, Jesús René Rodriguez-Sánchez, Raúl Diaz-Molina, Jesús René Machado-ContrerasAbstractTuberculosis (TB) has a high incidence, prevalence and mortality in the world. Due to its high level of transmission and long-term pharmacological treatment, it is important to have sensitive and specific diagnostic tests. Recently, the PureLyse®...
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
In this report, we review the current understanding of the pathogenesis, immunology, clinical epidemiology, diagnosis, treatment, and prevention of both incipient and subclinical TB, two emerging clinical states of an ancient bacterium. PMID: 30021818 [PubMed - in process]
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
Publication date: September 2018Source: Social Science &Medicine, Volume 212Author(s): Mishal S. Khan, Sonia Rego
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
PKC δ gene can induce macrophages to release inflammatory factors against Mycobacterium tuberculosis infection. Eur Rev Med Pharmacol Sci. 2018 Jul;22(13):4228-4237 Authors: Duan YT, Bi KY, Ma YS Abstract OBJECTIVE: To investigate the effect of PKC δ gene on the anti-tuberculosis activity of macrophages and the mechanism. MATERIALS AND METHODS: Bone marrow cells of PKC δ knockout mice and wild-type mice were cultured and L929 cells were induced to differentiate into macrophages. Lipopolysaccharide (LPS) and trehalose 6,6'-dimycolate (TDM) were used to stimulate macrophages respect...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
[IPS] Washington DC -Dozens of grown men peered from behind the barred doorway of a crammed window-less prison cell, eyes pleading desperately from sweaty faces.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 20 July 2018Source: The LancetAuthor(s): Ruvandhi R Nathavitharana, Madhukar Pai
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 20 July 2018Source: The LancetAuthor(s): Ankur Gupta-Wright, Elizabeth L Corbett, Joep J van Oosterhout, Douglas Wilson, Daniel Grint, Melanie Alufandika-Moyo, Jurgens A Peters, Lingstone Chiume, Clare Flach, Stephen D Lawn, Katherine FieldingSummaryBackgroundCurrent diagnostics for HIV-associated tuberculosis are suboptimal, with missed diagnoses contributing to high hospital mortality and approximately 374 000 annual HIV-positive deaths globally. Urine-based assays have a good diagnostic yield; therefore, we aimed to assess whether urine-based screening in HIV-positive inpatients for ...
Source: The Lancet - Category: General Medicine Source Type: research
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