Correspondence Consequence of prioritising pathogens for global antibiotic research
We agree with The Lancet Infectious Diseases that any prioritisation exercise to select important organisms for new antibiotic research inevitably leads to a decrease in emphasis for other pathogens omitted from the selection, such as mycobacteria.1 Restricting the list to promote research on antibacterial agents might be justifiable; however, Mycobacterium tuberculosis is a bacterium. It is insufficient to state that drug resistant tuberculosis “is already a globally established priority for which innovative new treatments are urgently needed”.
Condition: Latent Tuberculosis Infection Intervention: Sponsor: Hanyang University Recruiting
Padmapriyadarsini Chandrasekaran, Natarajan Saravanan, Ramalingam Bethunaickan, Srikanth Tripathy
Authors: Kawaguchi T, Oda K, Kido T, Kawanami T, Kawabata Y, Yatera K Abstract Although the majority of patients with Mycobacterium tuberculosis have pulmonary involvement, some cases have pleural involvement as extra-pulmonary sites of infection. We herein report a case of upper lobe-predominant pulmonary fibrosis that developed in a 47-year-old male with a history of bilateral tuberculous pleurisy. Based on his chest radiological findings, pleuroparenchymal fibroelastosis (PPFE) was most strongly suspected, and a surgical lung biopsy (SLB) was performed to obtain a pathological diagnosis. The SLB specimens showed...
Conclusions Thoracoscopic decortication of advanced tuberculous empyema is feasible, safe, and effective with good short- and long-term results in selected patients. In a substantial portion of patients, operative cultures required modifying drug treatment to treat underlying tuberculosis.
Abstract Surface localized microbial enolases’ binding with human plasminogen has been increasingly proven to have an important role in initial infection cycle of several human pathogens. Likewise, surface localized Mycobacterium tuberculosis (Mtb) enolase also binds to human plasminogen, and this interaction may entail crucial consequences for granuloma stability. The current study is the first attempt to explore the plasminogen interacting residues of enolase from Mtb. Beginning with the structural modeling of Mtb enolase, the binding pose of Mtb enolase and human plasminogen was predicted using protein‐protein d...
[CAJ News] Matatiele -MATATIELE in the Eastern Cape is synonymous with demarcation deadlocks of the past decade and recent service delivery protests but will soon be mentioned in the same breath with a multimillion Rand, world-class facility to treat rampant tuberculosis. Valued at more than R436 million, the Khotsong TB Hospital has become a pillar of hope for communities residing in and around the municipality with a population of over 12 million. Furthermore, the project has set aside over R94 million in construction work fo
Karen M. Garcia-Rodriguez, Anu Goenka, Maria T. Alonso-Rasgado, Rogelio Hern ández-Pando, Silvia Bulfone-Paus
(PLOS) Many health care providers in China -- especially those at village clinics and township health centers -- fail to correctly manage tuberculosis (TB) cases, according to a study involving standardized patients published this week in PLOS Medicine by Sean Sylvia of the University of North Carolina at Chapel Hill, USA, Chengchao Zhou of Shangdong University, China, and colleagues at the World Bank, McGill University, Stanford University and other institutions in China.
Contributors : Ethan Thompson ; Adam Penn Nicholson ; Daniel E Zak ; Thomas J Scriba ; Smitha ShankarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo define mechanisms that underlie progression of Mycobacterium tuberculosis (M.tb) infection to active tuberculosis (TB), we followed M.tb-infected adolescents longitudinally. Those who ultimately developed TB disease (“progressors”) were compared with matched controls, who remained healthy. Whole blood transcriptomic and plasma proteome a nalyses showed sequential modulation of immunological processes: type I...