SANGUINATE ™ (PEGylated Carboxyhemoglobin Bovine) Improves Cerebral Blood Flow to Vulnerable Brain Regions at Risk of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

ConclusionsWe demonstrated that this novel agent can improve regional CBF and may improve oxygen supply –demand balance. Clinical studies (likely with repeat dosing) are required to evaluate whether this effect can prevent DCI or cerebral infarction.
Source: Neurocritical Care - Category: Neurology Source Type: research

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Authors: Bailey HE Abstract A severe and unusual complication found in children with influenza is an acute necrotizing encephalopathy. A 20-month-old female with no significant past medical history was admitted to our facility, presenting with a 4-day history of worsening fever, upper respiratory symptoms, new-onset altered mental status and episodes of extensor posturing. The initial concern was a dystonic reaction secondary to promethazine following a recent diagnosis of influenza A virus. A head computed tomography scan indicated concern for widespread edema, and the video EEG revealed focal slowing in the front...
Source: The Neurodiagnostic Journal - Category: Neurology Tags: Neurodiagn J Source Type: research
Authors: White H, Venkatesh B, Jones M, Kruger PS, Walsham J, Fuentes H Abstract Objective: Although extensively studied in children, the safety and tolerability of ketone supplementation in adults is unclear, particularly in the acute brain injury population. The purpose of this study was to examine the feasibility and safety of inducing ketosis using an enteric ketogenic formulation and determine its impact on intracranial and cerebral perfusion pressures and metabolic parameters.Methods: Prospective interventional Phase II trial of ventilated critically ill patients with acute brain injury administered a ketogen...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
A perfectly aligned air ‐suspended nanowire array named “nanolene,” which is a 2D platform of 1D nanowire arrays, is demonstrated with high mechanical stability by means of a unique C‐channel‐shaped cross‐section of a nanowire. The proposed fabrication process results in reliable demonstrations of nanolenes wit h various materials and geometrical parameters. The unprecedented millimeter‐scale nanolenes are demonstrated and applied to advanced nanowire‐based devices. AbstractAir suspension and alignment are fundamental requirements to make the best use of nanowires' unique properties; however, satisf...
Source: Small - Category: Nanotechnology Authors: Tags: Communication Source Type: research
Demystifying Medicine Lecture Series Although the fundamental molecular pathophysiology of sickle cell anemia was elucidated in studies of this genetic disease starting more than 70 years ago, it is only in about the last two decades that this knowledge has led to specific therapies. Indeed in the last decade serious attention has turned to the possibility of a genetic cure of this condition. Have we finally cured sickle cell anemia? Not quite, but we may be on the cusp. Really. In a dozen clinical trials planned or underway, some at the NIH Clinical Center, researchers are applying gene therapy to cure this well-studied g...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Abstract The World Health Organization 2016 edition assigned anaplastic lymphoma kinase (ALK) rearrangement-associated renal cell carcinoma (ALK-RCC) as an emerging renal tumor entity. Identifying ALK-RCC is important because ALK inhibitors have been shown to be effective in treatment. Here, we report the case of a 14-year-old young man with ALK-RCC. Computed tomography revealed a well-demarcated 5.3-cm enhancing mass at the upper pole of the left kidney. There was no further history or symptoms of the sickle-cell trait. The patient underwent left radical nephrectomy. Pathologically, the mass was diagnosed as an u...
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
Conclusions: There is extensive and increasing evidence that a range of retinal vascular signs and disease are closely linked to CeVD, including subclinical and clinical CeVD. New technology including AI-DL will allow further translation to clinical utilization.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Disease of the Year: Cerebrovascular Disorders Source Type: research
ConclusionsOur findings show that prediabetes is associated with a poor functional outcome in intracerebral hemorrhage patients 1  month poststroke.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Authors: Vangipuarm G, Saraf SS, Zhang Q, Wang R, Rezaei KA PMID: 32095217 [PubMed]
Source: Journal of Ophthalmic and Vision Research - Category: Opthalmology Tags: J Ophthalmic Vis Res Source Type: research
We examined the protective effects of the natural flavonoid, quercetin, against cerebral vasospasm in an experimental rat subarachnoid haemorrhage (SAH) model. MATERIALS AND METHODS: Thirty-eight albino Wistar rats were divided into five groups as follows: group 1 (G1, n=8), no experimental intervention; group 2 (G2, n=8), subarachnoid physiological saline; group 3 (G3, n=8), SAH; group 4 (G4, n=7) SAH and low-dose (10 mg/kg) quercetin treatment; group 5 (G5, n=7), SAH and high-dose (50 mg/kg) quercetin treatment. Subarachnoid haemorrhage was induced by injection of 0.15 cc of autologous blood taken from the tail arter...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Authors: Kim HJ, Kang T, Kang MJ, Ahn HS, Sohn SY Abstract BACKGROUND: Hyperthyroidism is associated with various cardiovascular risk factors. However, the relationship between hyperthyroidism and myocardial infarction (MI) or stroke has not been fully elucidated; only a few studies have investigated the association of hyperthyroidism with survival after MI or stroke. METHODS: We included 59,021 hyperthyroid patients and 1,180,420 age- and sex-matched control cohort from the Korean National Health Insurance database. Blood pressure, body mass index (BMI), glucose and cholesterol level, and smoking history were ...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
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