Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case –Control Study (New England, USA)

Conclusions: We observed a modest association between ingestion of water with higher THMs (>95th percentile vs.45.73 μg/L) vs. the lowest quartile (≤6.83 μg/L) was 1.27 (95% CI: 0.83, 1.96). ORs for all lower categories of exposure were negative but close to the null (p-trend=0.41). The corresponding OR for cumulative intake (>1864.16 mg vs.≤138.05 mg) was 1.45 (95% CI: 0.95, 2.20), with a similar OR for the 90–95th percentile category. For all other exposure categories, the ORs were close to the null (p-trend=0.13). For average daily intake, the OR for the highest exposure group (>103.89 vs.6.83–15.73 228 296 0.86 0.66, 1.11  >15.73–26.75 241 296 0.96 0.74, 1.25  >26.75–37.14 150 178 0.97 0.72, 1.30  >37.14–45.73 47 59 0.92 0.59, 1.44  >45.73 58 59 1.27 0.83, 1.96 p-trend=0.41 Cumulative intake (mg)b,c  0–138.05 215 296 1.00  >138.05–398.33 246 296 1.12 0.86, 1.45  >398.33–801.93 243 296 1.09 0.84, 1.42  >801.03–1362.01 144 178 0.98 0.72, 1.33  >1362.01–1864.16 58 59 1.32 0.86, 2.04  >1864.16 68 59 1.45 0.95, 2.20 p-trend=0.13 Average daily intake (μg/d)b,c  0–8.69 214 296 1.00  >8.69–23.16 244 296 1.12 0.86, 1.46  >23.16–47.00 257 296 1.17 0.90, 1.52  >47.00–76.30 132 178 0.94 0.69, 1...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062 Received: 14 April 2017 Revised: 13 November 2017 Accepted: 15 November 2017 Published: 15 December 2017 Address correspondence to S.F. Farzan, 2001 N. Soto St., Los Angeles, CA, 90032. Telephone: (323)-442-5101; Email: sffarzan@usc.edu Supplemental Material is ava...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Author Affiliations open 1Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA 2Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA 3Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire, USA 4Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA PDF Version (188 KB) Abstract About This Article Supplemental Material Background: Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Author Affiliations open 1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada 2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain 4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain 5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada 6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA 7 Department of Economics, Brigham Young University, Provo, Utah, USA 8 Population Studies Division, Health Canada, Ottawa, Cana...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusions: Developmental BPA exposures heighten prostate cancer susceptibility in a complex dose- and lobe-specific manner. Importantly, elevated carcinogenic risk is found at doses that yield undetectable serum free BPA. Dose-specific epigenetic modifications of selected genes provide a mechanistic framework that may connect early-life BPA to later-life predisposition to prostate carcinogenesis. https://doi.org/10.1289/EHP1050 Received: 1 September 2016 Revised: 13 January 2017 Accepted: 19 January 2017 Published: 11 July 2017 Address correspondence to G.S. Prins, Dept. of Urology, University of Illinois at Chicago...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
By GEORGE BERGER, PHD I was diagnosed with aggressive but localized prostate cancer at a major Dutch academic hospital. My parameters were PSA 29 or 31, Gleason sum 4 + 4, and stage T2c. Fortunately, there were no detectable distant metastases. The specialist drew a simple image of my urinary tract and told me I was excluded from brachytherapy, which I had never heard of before, because of the size of my prostate. I had to choose between external beam radiotherapy (EBRT) and radical prostatectomy (RP). How on Earth could I choose rationally while knowing so little about prostate cancer? However, I had studied maths and phy...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized ADT Dutch Health Care System Gleason Prostate Prostate Cancer Sweden Source Type: blogs
Conclusions: We did not find clear evidence of an association between detailed estimates of lifetime total THM exposure and colorectal cancer in our large case–control study population. Negative associations with chloroform concentrations and ingestion suggest differences among specific THMs, but these findings should be confirmed in other study populations. Citation: Villanueva CM, Gracia-Lavedan E, Bosetti C, Righi E, Molina AJ, Martín V, Boldo E, Aragonés N, Perez-Gomez B, Pollan M, Gomez Acebo I, Altzibar JM, Jiménez Zabala A, Ardanaz E, Peiró R, Tardón A, Chirlaque MD, Tavani...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Articles January 2017 Source Type: research
Conclusions: Estimated intakes of meat mutagens were not significantly associated with CRC risk over 14 years of follow-up in the NHS and HPFS cohorts. Results for PhIP from red but not from white meat warrant further investigation. Citation: Le NT, Michels FA, Song M, Zhang X, Bernstein AM, Giovannucci EL, Fuchs CS, Ogino S, Chan AT, Sinha R, Willett WC, Wu K. 2016. A prospective analysis of meat mutagens and colorectal cancer in the Nurses’ Health Study and Health Professionals Follow-up Study. Environ Health Perspect 124:1529–1536; http://dx.doi.org/10.1289/EHP238 *These authors contributed equally to this...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article October 2016 Source Type: research
Abstract The purpose of this study is to investigate the clinical relevance of deletion of ovarian carcinoma 2/disabled homolog 2 (DOC-2/DAB2) interacting protein (DAB2IP) expression in human urothelial carcinoma (UC). We studied DAB2IP protein expression by immunohistochemistry in 130 UCs (90 of the bladder and 40 of the upper urinary tract) and 79 adjacent normal tissues and assessed its prognostic value in terms of recurrence-free and progression-free survival in superficial bladder UC. Twelve human UC cell lines were examined for DAB2IP messenger RNA (mRNA) and protein expression using quantitative RT-PCR and ...
Source: Virchows Archiv - Category: Pathology Source Type: research
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