Primary osteomyelitis caused by an NDM-1-producing K. pneumoniae strain of the highly virulent sequence type 23
Primary osteomyelitis caused by an NDM-1-producing K. pneumoniae strain of the highly virulent sequence type 23 Emerging Microbes &Infections 6, e57 (June 2017). doi:10.1038/emi.2017.43 Authors: Fabrice Compain, Alexis Vandenberghe, Marie Gominet, Nathalie Genel, David Lebeaux, Astrid Ramahefasolo, Isabelle Podglajen &Dominique Decré
Conclusion: A higher frequency of jaw osteomyelitis secondary to COD was found compared to previous studies. No significant association was shown between any of the COD types and secondary osteomyelitis.Keywords: Cemento-osseous dysplasia, South Africa, patient population.
The staphylococcal accessory regulator (sarA) plays an important role in Staphylococcus aureus infections, including osteomyelitis, and the msaABCR operon has been implicated as an important factor in modulating expression of sarA. Thus, we investigated the contribution of msaABCR to sarA-associated phenotypes in the S. aureus clinical isolates LAC and UAMS-1. Mutation of msaABCR resulted in reduced production of SarA and a reduced capacity to form a biofilm in both strains. Biofilm formation was enhanced in a LAC msa mutant by restoring the production of SarA, but this was not true in a UAMS-1 msa mutant. Similarly, extra...
Alveolar bone resection or debridement is a common surgical technique performed in the oral and maxillofacial surgery department for the treatment of chronic osteomyelitis and benign lesions of the bone. The most common complications include incomplete resection of the lesion, because of variations that make it difficult to identify the margin, and injury of the inferior alveolar nerve. Complete removal of necrotic bone is important because of the risk of disease recurrence.1
ConclusionThe loss of the ZF-domain and the impaired T cell proliferation accompanied by almost complete persistence of na ïve T cells despite severe infections are suggestive for a profound immunodeficiency. Allogenic HSCT should be considered early for these patients before chronic sequelae occur.
Many large series studies have reported that non-tuberculous mycobacteria (NMT) can be attributed to both pulmonary and extrapulmonary diseases. Of the extrapulmonary diseases caused by NMT, skin and soft tissue infection was the most common (Chen et al., 2011). These infections were usually associated with surgical procedures or trauma (Senda et al., 2011; Beam et al., 2014; Legout et al., 2012; Chen et al., 2011). Mycobacteria arupense is an extremely rare cause of soft tissue infection and osteomyelitis.
Introduction: Osteonecrosis of the jaw (ONJ) is characterized by a chronic wound in the oral mucosa with exposed necrotic bone. This condition may occur following tooth extraction or other types of oral surgery, but may develop spontaneously adjacent to infected teeth or implant. The lesion may be symptomatic but is often asymptomatic. Both irradiation to the head and neck region (osteoradionecrosis) and bacterial infection, mainly Staphylococcus aureus (osteomyelitis), were long been known to cause this phenomenon (1).
Conditions: Bloodstream Infection; Pneumonia, Bacterial; Intra-abdominal Infection; Urinary Tract Infections; Osteomyelitis; Central Nervous System Infections; Acute Bacterial Skin and Skin Structure Infection Intervention: Diagnostic Test: Detection of CRKp colonization Sponsor: SCARE (Study group for carbapenem resistance) Not yet recruiting
Publication date: January 2020Source: Journal of Comparative Pathology, Volume 174Author(s): N. de Bruijn, C. Ter Veen, A. Heuvelink, A. Feberwee
Authors: Traven SA, Synovec JD, Walton ZJ, Leddy LR, Suleiman LI, Gross CE Abstract INTRODUCTION: The purpose of this study is to investigate the current disparities for major lower extremity amputation in patients with critical limb ischemia (CLI) and infection. METHODS: A retrospective analysis of the National Surgical Quality Improvement Program's database for the years 2011 to 2017 was conducted. Multivariate models were used to isolate the effect of race and ethnicity on the likelihood of a below-knee or above-knee amputation (BKA and AKA, respectively) for CLI secondary to type 2 diabetes mellitus, athero...