Raleigh biopharma to go public through reverse merger

Raleigh-based Innovate Biopharmaceuticals is poised to become a public company through a reverse merger with Simi Valley, California-based Monster Digital (Nasdaq: MSDI). Innovate said Monday that it has entered into a nonbinding letter of intent with Monster Digital that would ultimately see Innovate trade on the Nasdaq exchange under a new ticker symbol. Innovate is developing a pipeline of drugs for the treatment of conditions, including celiac disease – an au toimmune disorder related to consuming…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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Publication date: Available online 5 June 2018 Source:Journal of the Academy of Nutrition and Dietetics Author(s): Georgina Rubal-Peace, Caroline Sepp
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
(Natural News) There was a time when celiac disease (CD) was known as a rare condition that almost exclusively afflicted individuals of European descent. Today, one out of 100 persons around the world is thought to have the disease. To understand how a supposedly uncommon genetic disorder now afflicts such a considerable percentage of humanity,...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
AbstractPurpose of ReviewTo provide an update on the pathogenesis of enteropathy-associated T cell lymphoma (EATL) and its relationship with refractory celiac disease (RCD), in light of current knowledge of immune, genetic, and environmental factors that promote neoplastic transformation of intraepithelial lymphocytes (IELs).Recent FindingsEATL frequently evolves from RCD type II (RCD II) but can occur “de novo” in individuals with celiac disease. Recurrent activating mutations in members of the JAK/STAT pathway have been recently described in EATL and RCD II, which suggests deregulation of cytokine signaling t...
Source: Current Hematologic Malignancy Reports - Category: Hematology Source Type: research
Given the increased morbidity and potential mortality of celiac disease, guidelines recommend screening high-risk individuals, including first-degree relatives of patients. We assessed how commonly celiac disease testing occurs in these individuals and identified factors that influence testing.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
In this study, we aimed to identify correlations between fecal microbiota, serum tumor necrosis factor alpha (TNF-) and fecal short-chain fatty acids (SCFAs) in healthy children and children with CD after administration of probiotic Bifidobacterium breve BR03 and B632.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Original article Source Type: research
uul A Abstract Hypogonadism may be suspected if puberty is delayed. Pubertal delay may be caused by a normal physiological variant, by primary ovarian insufficiency (Turner syndrome), or reflect congenital hypogonadotropic hypogonadism (HH; genetic) or acquired HH (brain lesions). Any underlying chronic disease like inflammatory bowel disease, celiac disease, malnutrition (anorexia or orthorexia), or excessive physical activity may also result in functional HH. Thus, girls with delayed puberty should be evaluated for an underlying pathology before any treatment, including oral contraception, is initiated. Estrogen...
Source: Endocrine Development - Category: Endocrinology Authors: Tags: Endocr Dev Source Type: research
Pancreatic cancer (PC) is the fourth leading cause of cancer-related deaths in developed countries with an overall 5-year survival rate of 7% [1], and is expected to be the second cancer cause of death by 2030 [2]. Surgery still remains the best therapy for potentially curative purposes, but only 15-20% of the patients are candidates for resection. The resectability criteria are based on the absence of distant metastasis and the extent of vascular involvement. For a long time, tumours with no contact with major mesenteric or celiac vessels were considered resectable, and those with invasion of the arteries or mesenteric-po...
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Anti-Tumour Treatment Source Type: research
ConclusionThe prevalence of CD in cryptogenic cirrhosis was 13.1%. Screening for CD is recommended for cryptogenic cirrhosis. Hepatic functions improve with a GFD in CD patients with cirrhosis.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Authors: Chetcuti Zammit S, Sidhu R, Sanders DS Abstract INTRODUCTION: Coeliac disease is an autoimmune mediated condition in response to gluten. A combination of innate and adaptive immune responses results in villous shortening in the small bowel which can be morphologically picked up on capsule endoscopy. Small bowel capsule endoscopy is the only imaging modality that can provide mucosal views of the whole length of the small bowel whilst histology is generally limited to the proximal small bowel. Radiological modalities are not designed to pick up changes in villous morphology. Areas covered: In this review, we...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Abstract The study purpose was to describe dietary intake and the factors influencing micronutrient supplements (MS) use in Celiac Disease (CD) ± Type 1 Diabetes (T1D). Three-day food records collected from parents of youth (3-18 years) with CD (n = 14) ± T1D (n = 10) were assessed for macro and micronutrient intake, diet quality (DQ), glycemic index (GI), glycemic load (GL), and food group intake. Focus group methodology and thematic concept analysis were conducted to determine factors influencing adolescent MS use. Mean ± ...
Source: Canadian Journal of Dietetic Practice and Research - Category: Nutrition Authors: Tags: Can J Diet Pract Res Source Type: research
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