Papers of note in Science Translational Medicine 9 (394)

This week’s articles describe how broccoli can combat type 2 diabetes, how monocytes contribute to the failure of organ transplant grafts, and how to more durably treat RET- or KRAS-driven lung cancer.
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Editors ' Choice Source Type: news

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Publication date: Available online 9 October 2018Source: Pharmacological ResearchAuthor(s): D. Visca, P. Pignatti, A. Spanevello, E. Lucini, E. La RoccaAbstractDiabetes is a common metabolic disorder affecting the entire body with high morbidity and mortality worldwide. The major complications related to diabetes are mostly due to the macrovascular and microvascular bed impairment due to metabolic, hemodynamic and inflammatory factors. However, studies over the past decades have added also the lung as a target organ in both type 1 and type 2 diabetes. Diabetes has always been addressed as a major comorbidity conditioning t...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Breast cancer is the most prevalent cancer in the U.S., affecting almost 85 of every 100,000 Americans, according to recent data from the World Health Organization’s International Agency for Research on Cancer (IARC). Around the globe, 627,000 people are projected to die from breast cancer this year alone. The silver lining is that with early detection and proper care, breast cancer is among the most treatable forms of the disease. In the U.S., breast cancer deaths dropped by 40% between 1989 and 2015, thanks to better screening and access to care — but a large body of research suggests that widespread adoption...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized breast cancer news Source Type: news
In this study we addressed the role of a mitochondrial transporter commonly upregulated in cancer cells, SLC25A10, for cell survival and metabolism in the presence of metformin. SLC25A10 is a carrier in the mitochondrial inner membrane that transports malate and succinate out of the mitochondria, in exchange of phosphate and sulfate. We show that metformin treatment results in decreased gene expression of the SLC25A10 carrier both in lung cancer A549 mock cells and A549 SLC25A10 knockdown (siSLC25A10) cells. The decrease was even more pronounced when cells were grown at low glucose concentrations. The expression levels of ...
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research
Heart problems that were “largely preventable” killed around 415,000 Americans in 2016, new data from the Centers for Disease Control and Prevention (CDC) says, highlighting the importance of proactive interventions. Under its new Million Hearts campaign, which aims to prevent a million heart attacks and strokes by 2022, the CDC looked at 2016 data and identified approximately 2.2 million hospitalizations and 415,000 deaths caused by heart attacks, strokes, heart failure and related conditions that likely could have been avoided. The total number of deaths related to heart issues is even higher — in 2015,...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Heart Disease onetime Source Type: news
Authors: Zeng S, Gan HX, Xu JX, Liu JY Abstract BACKGROUND AND OBJECTIVE: In recent years, many studies have investigated metformin and its effects on lung cancer. However, since previous studies have shown that the relationship between metformin and lung cancer is complicated, we performed a meta-analysis to analyze this relationship. MATERIAL AND METHODS: An electronic database search was conducted using PubMed, Embase, and Cochrane library. Outcomes were quantified with hazard ratios and 95% confidence intervals to compare lung cancer survival in patients treated with or without metformin. RESULTS: Ten s...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
It ’s difficult to open a newspaper nowadays without seeing an article about artificial intelligence. These column-inches spark our imaginations with heady visions of possible futures and crease our brows with concern in equal measure. But one thing you cannot escape is that AI is here now and it’s only going to become more pervasive.While fear of an unknown technology is understandable, in many ways it does a disservice to the incredible impact that AI is already having on the world around us. In the healthcare space alone, it is offering ways to fundamentally rethink clinical practice, speeding up diagnosis, ...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
Imagine you have a friend named Justin. He is a schoolteacher. Honest, hardworking, doesn’t smoke, rarely drinks alcohol, sleeps well, doesn’t take drugs, shows up at work every day. He has also chosen to be vegetarian. Another friend of yours, an auto mechanic named Tommy, eats fast food, loves fried chicken, drinks too much beer on the weekends, likes to drive fast cars, and sometimes gets into legal tangles. He smokes cigarettes, though has limited it to only half-a-pack per day. Late weekends, some weekday nights, sleep cut short to just two or three hours. Tommy is not a vegetarian, but likes his burgers r...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle Source Type: blogs
Abstract DPP-IV "a moonlighting protein" has immerged as promising pathway to control Type 2 diabetes as well as found to play key role in earlier stages of cancer. Here we have reported design, synthesis and applications of aminocoumarin derivatives as DPP-IV inhibitors. Compounds have been synthesized and studied for their DPP-IV inhibition activity. Three compounds have shown moderate inhibition at 100 µM concentration. All compounds were also screened for their anticancer activity against A549 (Lung cancer cell line), MCF-7 (Breast cancer cell line) using MTT assay. One of the compounds has s...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Tags: Bioorg Chem Source Type: research
Followers of the Undoctored and Wheat Belly books and lifestyle understand a basic truth in logic: Just because something is less bad does not necessarily make it good. Low-tar cigarettes have less of the toxic compounds that leave the brown residue–“tar”–after tobacco is burned, but smoking low-tar cigarettes does not reduce risk for lung cancer, mouth/throat cancer, or cardiovascular disease. From Stanford.edu  on the impact of tobacco advertising: Claims of low ‘tar,’ less ‘tar,’ or even lowest ‘tar’ have been circulating in cigarette advert...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Grain Free Lifestyle News & Updates blood sugar diabetes diy health Dr. Davis grain-free grains healthy whole-grains low-carb low-fat undoctored wheat wheat belly Wheat Belly Total Health Source Type: blogs
ConclusionsAtypical manifestations of pulmonary sarcoidosis are diagnostically challenging because the clinical and radiographic features of the disease mimic those of a malignancy. We aimed to illustrate a unique etiology of a lung mass and the importance of maintaining a broad differential diagnosis. Nonetheless, with the possibility of a malignancy, a high index of suspicion is necessary for timely diagnosis and optimal management.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
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