Papers of note in Science Translational Medicine 9 (394)

This week’s articles describe how broccoli can combat type 2 diabetes, how monocytes contribute to the failure of organ transplant grafts, and how to more durably treat RET- or KRAS-driven lung cancer.
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Editors ' Choice Source Type: news

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Imagine you have a friend named Justin. He is a schoolteacher. Honest, hardworking, doesn’t smoke, rarely drinks alcohol, sleeps well, doesn’t take drugs, shows up at work every day. He has also chosen to be vegetarian. Another friend of yours, an auto mechanic named Tommy, eats fast food, loves fried chicken, drinks too much beer on the weekends, likes to drive fast cars, and sometimes gets into legal tangles. He smokes cigarettes, though has limited it to only half-a-pack per day. Late weekends, some weekday nights, sleep cut short to just two or three hours. Tommy is not a vegetarian, but likes his burgers r...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle Source Type: blogs
Abstract DPP-IV "a moonlighting protein" has immerged as promising pathway to control Type 2 diabetes as well as found to play key role in earlier stages of cancer. Here we have reported design, synthesis and applications of aminocoumarin derivatives as DPP-IV inhibitors. Compounds have been synthesized and studied for their DPP-IV inhibition activity. Three compounds have shown moderate inhibition at 100 µM concentration. All compounds were also screened for their anticancer activity against A549 (Lung cancer cell line), MCF-7 (Breast cancer cell line) using MTT assay. One of the compounds has s...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Tags: Bioorg Chem Source Type: research
Followers of the Undoctored and Wheat Belly books and lifestyle understand a basic truth in logic: Just because something is less bad does not necessarily make it good. Low-tar cigarettes have less of the toxic compounds that leave the brown residue–“tar”–after tobacco is burned, but smoking low-tar cigarettes does not reduce risk for lung cancer, mouth/throat cancer, or cardiovascular disease. From  on the impact of tobacco advertising: Claims of low ‘tar,’ less ‘tar,’ or even lowest ‘tar’ have been circulating in cigarette advert...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Grain Free Lifestyle News & Updates blood sugar diabetes diy health Dr. Davis grain-free grains healthy whole-grains low-carb low-fat undoctored wheat wheat belly Wheat Belly Total Health Source Type: blogs
ConclusionsAtypical manifestations of pulmonary sarcoidosis are diagnostically challenging because the clinical and radiographic features of the disease mimic those of a malignancy. We aimed to illustrate a unique etiology of a lung mass and the importance of maintaining a broad differential diagnosis. Nonetheless, with the possibility of a malignancy, a high index of suspicion is necessary for timely diagnosis and optimal management.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusion No manifesto will by itself change a two-thousand-year-old system, any more than Martin Luther’s 95 theses did. Establishments die hard: 100 years ago, in 1918, Max Planck was awarded the Nobel Prize in physics, and in his Scientific Autobiography he talked about the adoption of change by any establishment: A new scientific truth does not win adoption by convincing its opponents and making them see the light, but because its opponents eventually die. A manifesto can, though, kindle new thinking among those who do see the light. Planck continued: … and a new generation comes up that is familiar wi...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Empowered Patients Healthcare Design Healthcare Policy digital digital health doctor empowerment future Health 2.0 Innovation manifesto patient empowerment Personalized medicine philosophy technology Source Type: blogs
Journal of Surgical Oncology, EarlyView.
Source: Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Source Type: research
Two medtech titans are teaming up to market a software GPS solution to detect lung cancer. Medtronic and Royal Philips announced the partnership and unveiled the jointly developed LungGPS Patient Management Platform earlier this week. To date, lung cancer remains the No. 1 cancer killer in the world, accounting for more cancer deaths than breast, colon, and prostate cancer combined, according to statistics from the American Cancer Society. “From my perspective, I think both organizations realize that more needs to be done to help transform lung cancer from a death sentence or deadly diseases, to something that is mor...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
CONCLUSIONS: Well-designed and well-conducted RCTs have shown no beneficial effect of selenium supplements in reducing cancer risk (high certainty of evidence). Some RCTs have raised concerns by reporting a higher incidence of high-grade prostate cancer and type 2 diabetes in participants with selenium supplementation. No clear evidence of an influence of baseline participant selenium status on outcomes has emerged in these studies.Observational longitudinal studies have shown an inverse association between selenium exposure and risk of some cancer types, but null and direct relations have also been reported, and no system...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
AbstractPyruvate carboxylase (PC), an anaplerotic enzyme, plays an essential role in various cellular metabolic pathways including gluconeogenesis, de novo fatty acid synthesis, amino acid synthesis, and glucose-induced insulin secretion. Deregulation of PC expression or activity has long been known to be associated with metabolic syndrome in several rodent models. Accumulating data in the past decade clearly showed that deregulation of PC expression is associated with type 2 diabetes in humans, while targeted inhibition of PC expression in a mouse model reduced adiposity and improved insulin sensitivity in diet-induced ty...
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research
This study aimed to examine the association between green tea intake and COPD with the use of a nationwide representative database.MethodsThis study was designed as a cross-sectional survey with the use of data from the Korean National Health and Nutritional Examination Survey collected between 2008 and 2015. Of these participants, 13,570 participants aged ≥40 y were included in the study population. COPD was defined as forced expiratory volume in 1 s (FEV1) divided by forced vital capacity (FVC)
Source: Journal of Nutrition - Category: Nutrition Source Type: research
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