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Papers of note in Science Translational Medicine 9 (394)

This week’s articles describe how broccoli can combat type 2 diabetes, how monocytes contribute to the failure of organ transplant grafts, and how to more durably treat RET- or KRAS-driven lung cancer.
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Editors ' Choice Source Type: news

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Despite what the textbooks say or how much research is devoted to substance use disorder, I still meet people who feel that addiction is a “choice,” and that these patients don’t need “treatment” (you made your bed, and now you can just lay in it). To a certain degree, this is true. Like Little Debbie cakes and type 2 diabetes, cigarettes and lung cancer, lack of exercise and essential hypertension, addiction does start with a choice. And instead of arguing about how this turns into a disease or trying to convince you to have a bit of compassion, I only wish to show others that: Addiction does...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Education Emergency Medicine Medical school Primary Care Source Type: blogs
Abstract BACKGROUND: Metformin (MF), a diabetic drug, has antineoplastic activity as adjuvant therapy for breast cancer and prostate cancer. MF is thought to work via inhibition of mammalian target of rapamycin and activation of p53 and liver kinase B1 via adenosine 5'-monophosphate-activated protein kinase. We investigated survival, recurrences and metastasis in patients with type 2 diabetes mellitus (DM2) along with colorectal cancer (CC) or lung cancer (LC) taking MF using the electronic medical record in Memphis Veterans Affairs Medical Center (colon, n = 202; lung, n = 180). MATERIALS AND METHODS: Patien...
Source: The American Journal of the Medical Sciences - Category: General Medicine Authors: Tags: Am J Med Sci Source Type: research
AbstractWe aimed to evaluate the criterion validity of the 2015 food-based Dutch dietary guidelines, which were formulated based on evidence on the relation between diet and major chronic diseases. We studied 9701 participants of the Rotterdam Study, a population-based prospective cohort in individuals aged 45  years and over [median 64.1 years (95%-range 49.0–82.8)]. Dietary intake was assessed at baseline with a food-frequency questionnaire. For all participants, we examined adherence (yes/no) to fourteen items of the guidelines: vegetables (≥200 g/day), fruit (≥200 g/day), whole-grains (&...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
"Nine lifestyle changes can reduce dementia risk," BBC News reports. A major review by The Lancet has identified nine potentially modifiable risk factors linked to dementia. The risk factors were: low levels of education midlife hearing loss physical inactivity high blood pressure (hypertension) type 2 diabetes obesity smoking depression social isolation However, it's important to note that even if you add up the percentage risk of all of these factors, they only account for about 35% of the overall risk of getting dementia. This means about 65% of the risk is still due to factors you can't co...
Source: NHS News Feed - Category: Consumer Health News Tags: Neurology QA articles Source Type: news
PMID: 28684163 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research
You know the type. The macho guy who’s rough, tough, go-it-alone, leader-of-the-pack, help-not-wanted. Macho man may put off seeing a doctor for a checkup – because he thinks he’s invincible, doesn’t get sick, it’s a waste of time, only for the weak. Physicians at the University of Maryland Medical Center say some men only give in when they have symptoms, when major treatments are required, or when preventive steps are more demanding. Even so, it’s never too late to start on the road to health. June, Men’s Health Month, is a great time to focus on preventable health problems and en...
Source: Life in a Medical Center - Category: Universities & Medical Training Authors: Tags: Health Tips Heart/Cardiac Care heart health mens health Source Type: blogs
Abstract This week's articles describe how broccoli can combat type 2 diabetes, how monocytes contribute to the failure of organ transplant grafts, and how to more durably treat RET- or KRAS-driven lung cancer. PMID: 28634206 [PubMed - in process]
Source: Science Signaling - Category: Biomedical Science Authors: Tags: Sci Signal Source Type: research
He was born in 1927 on this day. Calvin Coolidge was president. Charles Lindbergh landed in Paris the day before. Wonder Bread was founded. Babe Ruth set his home run record, Coca-Cola cost 5 cents, the first talking picture was released (Al Jolson), and the 15 millionth Model T rolled out of the factory. While a memorable year, for me what counts is my dad, my best friend, was born. And despite macular degeneration, COPD, type 2 diabetes, an irregular heart beat, hearing loss, and having beat both lung cancer and throat cancer, plus a strange throat condition called dysphagia which makes swallowing difficult and painful, ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of cancer cells to evade homeostasis and proliferate uncontrollably while avoiding programmed cell death/apoptosis is acquired through mutations to key signaling molecules, which regulate pathways involved in cell proliferation and survival and these mutations allow them to develop resistance to many chemotherapeutic agents, highlighting the need for development of new potent anti-cancer agents. Metformin has long been used as a treatment for type 2 diabetes and has recently attracted attention as a potential agent to be used in the treat...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
In conclusion,metformin use may reduce lung cancer risk in patients with type 2 diabetes mellitus. PMID: 28456789 [PubMed - as supplied by publisher]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
More News: Cancer | Cancer & Oncology | Diabetes | Diabetes Type 2 | Endocrinology | Environmental Health | Lung Cancer | Lung Transplant | Science | Transplant Surgery | Transplants