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Effect of moxibustion on tumor necrosis factor- α and nuclear transcription factor kappa B in ankle joints of rats with rheumatoid arthritis

AbstractObjectiveTo observe the effect of moxibustion on the expressions of tumor necrosis factor- α (TNF-α) and nuclear transcription factor kappa B (NF-κB) proteins in ankle joints of rats with rheumatoid arthritis (RA), and to explore the anti-inflammatory mechanism of moxibustion in the treatment of RA.MethodsAdjuvant arthritis (AA) rat models were induced and used as rat models of RA. Rats were randomly divided into a normal group, a model group, a moxibustion group and a saline group. Rats in the normal and model groups were not treated; rats in the moxibustion group accepted treatment by moxibustion at Zusanli (ST 36) and Shenshu (BL 23) after modeling; rats in the saline group were injected with 0.15 mL saline to the bottom of the left hind paw and had no other treatments. Hematoxylin-eosin (HE) staining was used to observe the histopathological changes of rats ’ ankle joints under light microscope. Immunohistochemistry was used to observe the expressions of TNF-α and NF-κB in ankle joints of rats.ResultsCompared with the normal group, the rats ’ ankle joints in the model group showed disorganization, joint surface defect, and significantly increased mean optical density (MOD) of TNF-α and NF-κB (allP
Source: Journal of Acupuncture and Tuina Science - Category: Complementary Medicine Source Type: research

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Abstract Background/Aims: To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA). Methods: Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in this analysis. Patients were further divided into two groups according to the time to diagnosis from symptom onset: the early diagnosis group (time to diagnosis ≤ 1 year) and the late diagnosis group (time to diagnosis> 1 year). Using the multivariable regression model, we identified factors associat...
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
(Reuters) - The U.S. Food and Drug Administration approved Pfizer Inc's second biosimilar to Johnson&Johnson's blockbuster rheumatoid arthritis drug, Remicade, the company said on Wednesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Conclusions Important other autonomy support for physical activity may hold positive consequences for LPA engagement and related mental health states in RA, independent of the negative effects of lower-limb functional disability.
Source: Mental Health and Physical Activity - Category: Psychiatry & Psychology Source Type: research
Conclusion This is the first multicentre clinical study to demonstrate that the antiadipogenic compounds–rich herbal Fufang (formula) XLGB is effective in preventing CS-associated ONFH in patients with immune-inflammatory diseases under CS treatment.
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Conclusion ILD frequency has increased among RA patients due to improved detection by HRCT. High titer of ACPA was associated with extent and patterns of severity of ILD in RA patients. When high ACPA titer is associated with low CDAI score, physician could suspect lung involvement.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
AbstractHypertension is highly prevalent in patients with rheumatoid arthritis (RA). In other populations, high sodium (Na+) and low potassium (K+) intake are associated with an increased risk of hypertension, and in animal models, a high salt intake exacerbated arthritis. Patients with RA have many comorbidities associated with salt sensitivity, but their salt intake and its relationship to blood pressure and inflammation is unknown. Using the Kawasaki formula, Na+ and K+ urinary excretion (reflecting intake) was estimated in 166 patients with RA and 92 controls, frequency matched for age, sex, and race. Inflammatory mark...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Authors: Rigby WFC, Lampl K, Low JM, Furst DE Abstract Safety concerns associated with many drugs indicated for the treatment of rheumatoid arthritis (RA) can be attenuated by the early identification of toxicity through routine laboratory monitoring; however, a comprehensive review of the recommended monitoring guidelines for the different available RA therapies is currently unavailable. The aim of this review is to summarize the current guidelines for laboratory monitoring in patients with RA and to provide an overview of the laboratory abnormality profiles associated with each drug indicated for RA. Recommendati...
Source: International Journal of Rheumatology - Category: Rheumatology Tags: Int J Rheumatol Source Type: research
Conclusion: In first-degree relatives without RA, ACPA positivity is associated with higher SBP and DBP. Subclinical autoimmune processes and ACPA may play a role in the vascular changes potentially leading to hypertension prior to RA onset.Am J Nephrol 2017;46:481 –487
Source: American Journal of Nephrology - Category: Neurology Source Type: research
Mothers with rheumatoid arthritis are more likely to have children with selected chronic health problems, including thyroid disease, according a to a study published inArthritis Care& Research.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
This study included 85 RA patients classified according to the ACR/EULAR 2010 criteria and 67 CS. Polymerase chain reaction was used to identify IL1RN VNTR polymorphism, the expression of sIL-1Ra (secreted isoform) mRNA was determined by SYBR Green-based real time quantitave-PCR assay, and IL-1Ra soluble levels quantification was evaluated by ELISA test. RA patients had higher soluble levels of IL-1Ra than CS (p 
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
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