Effect of moxibustion on tumor necrosis factor- α and nuclear transcription factor kappa B in ankle joints of rats with rheumatoid arthritis

AbstractObjectiveTo observe the effect of moxibustion on the expressions of tumor necrosis factor- α (TNF-α) and nuclear transcription factor kappa B (NF-κB) proteins in ankle joints of rats with rheumatoid arthritis (RA), and to explore the anti-inflammatory mechanism of moxibustion in the treatment of RA.MethodsAdjuvant arthritis (AA) rat models were induced and used as rat models of RA. Rats were randomly divided into a normal group, a model group, a moxibustion group and a saline group. Rats in the normal and model groups were not treated; rats in the moxibustion group accepted treatment by moxibustion at Zusanli (ST 36) and Shenshu (BL 23) after modeling; rats in the saline group were injected with 0.15 mL saline to the bottom of the left hind paw and had no other treatments. Hematoxylin-eosin (HE) staining was used to observe the histopathological changes of rats ’ ankle joints under light microscope. Immunohistochemistry was used to observe the expressions of TNF-α and NF-κB in ankle joints of rats.ResultsCompared with the normal group, the rats ’ ankle joints in the model group showed disorganization, joint surface defect, and significantly increased mean optical density (MOD) of TNF-α and NF-κB (allP
Source: Journal of Acupuncture and Tuina Science - Category: Complementary Medicine Source Type: research

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A 70–year-old female patient with rheumatoid arthritis affecting multiple joints who is rheumatoid-factor positive but without organ or system failure returns for her third infliximab infusion. She is scheduled to receive 500 mg of the drug. How should this encounter be coded? 96413, 96415, J1745 x 50; ICD 10: M05.79 96413, 96415, J1745 x 50;... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Billing/Coding From the College adalimumab Billing & Coding denosumab ibandronate sodium infliximab Source Type: research
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Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Research Reviews Rheumatoid Arthritis anti-citrullinated protein antibody (ACPA) sputum Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Publication date: Available online 19 November 2018Source: Brain, Behavior, and ImmunityAuthor(s): Sarah A. Woller, Cody Ocheltree, Stephanie Y. Wong, Anthony Bui, Yuya Fujita, Gilson Gonçalves dos Santos, Tony L. Yaksh, Maripat CorrAbstractIn rheumatoid arthritis, joint pain can persist despite resolution of swelling. Similarly, in the murine K/BxN serum transfer model, a persistent tactile allodynia is observed after the resolution of joint inflammation (post-inflammatory pain) in male mice. Here, we found female wild type (WT) mice show inflammatory, but reduced post-inflammatory tactile allodynia. The transition...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractAimDiscrepancies exist between international treatment guidelines and current Australian Pharmaceutical Benefits Scheme (PBS) criteria for funding biologic disease ‐modifying antirheumatic drug (bDMARD) prescribing in psoriatic arthritis (PsA). We aimed to determine the prevalence of minimal disease activity (MDA) achievement and differences in inflammatory marker levels between PsA patients who have and have not met the Australian PBS criteria for bDMARDs.MethodConsecutive participants diagnosed with PsA were assessed for MDA components and serum inflammatory markers. For those on bDMARDs, joint counts and infla...
Source: APLAR Journal of Rheumatology - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractObjectivesTo study clinical and patient reported outcomes for the Virtual Monitoring Clinic (VMC), a remote nurse ‐led telemonitoring service for monitoring Rheumatoid Arthritis (RA) patients treated with disease‐modifying antirheumatic drugs (DMARDs).MethodsPatients with stable RA enrolled in the VMC were followed up prospectively. The primary outcomes evaluated at 1 ‐year follow‐up were: Disease Activity Score‐28 (DAS28), Routine Assessment of Patient Index Data 3 (RAPID3), and patient satisfaction assessed using an 11‐point Likert scale.ResultsOf the 251 patients enrolled, 186 completed 1 ‐year of ...
Source: APLAR Journal of Rheumatology - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This article reviews the new developments in RA research and discusses the latest insights into epidemiology, risk factors, predisease states, and outcomes.
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Authors: Ciechanowicz P, Rakowska A, Sikora M, Rudnicka L Abstract The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti-inflammatory properties and have been approved in many countries for the treatment of rheumatoid arthritis (tofacitinib, baricitinib) and myelofibrosis or polycythemia vera (ruxolitinib). The aim of the publication was to summarize and critically analyze the efficacy and safety of JAK-inhibitors in skin diseases, such as psoriasis, alopecia areata, atopic dermatitis and vitilig...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Publication date: Available online 16 November 2018Source: Journal of the Saudi Heart AssociationAuthor(s): Mohamed Naseem, Sameh Samir, Ibtsam Khairat Ibrahim, Lamiaa Khedr, Abeer Abd Elmonem ShahbaAbstractObjectivesDisease activity has been considered as an independent cardiovascular risk factor in patients with rheumatoid arthritis (RA). We aimed to evaluate the effect of RA disease activity on left ventricular (LV) and right ventricular (RV) functions by speckle tracking echocardiography (STE).MethodsA total of 120 RA patients without evidence of cardiovascular disease and 40 healthy control individuals were included i...
Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
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