Urinary Volatile Organic Compounds as Potential Biomarkers in Idiopathic Membranous Nephropathy

Objective: To detect urinary volatile organic compounds (VOCs) in patients with idiopathic membranous nephropathy (iMN) and normal controls, and whether or not the urinary VOCs can act as biomarkers for diagnosis of iMN independent of renal biopsy. Materials and Methods: Gas chromatography/mass spectrometry (GC/MS) was used to assess the urine collected from 63 iMN patients and 15 normal controls. The statistical methods of principal component analysis (PCA) and partial least squares discriminant analysis (PLSDA) were performed to process the final data in CDF format which were converted from GC/MS data. Results: Six VOCs in the urine of iMN patients exhibited significant differences from those of normal controls: carbamic acid, monoammonium salt, 2-pentanone, 2,4-dimethyl-pentanal, hydrogen azide, thiourea and 4-heptanone were significantly higher than in controls (p
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research