The Utility of Screening Colonoscopy During Kidney Transplant Evaluation.
CONCLUSIONS: The overall rate of adenomatous findings on colonoscopy was higher among patients with pretransplant end-stage renal disease than in the general population, as shown in other studies. Age, sex, dialysis vintage up to 3 years, and hypertensive renal failure were associated with adenomatous polyps of the colon in this study population. Because adenomatous polyp rates are high in patients with chronic kidney disease who are undergoing transplant evaluation and colonoscopic findings do not appear to delay transplant evaluations or listing rates, screening colonoscopies should be encouraged. PMID: 28621634 [PubMed - as supplied by publisher]
CONCLUSIONS SMYD2 expression was upregulated in PTC tissues and significantly related to the poorer prognosis of PTC patients. Our studies suggested the potential role of SMYD2 as a new therapeutic target and prognostic biomarker in human PTC. PMID: 30319138 [PubMed - in process]
Combination VEGFR/immune checkpoint inhibitor therapy: a promising new treatment for renal cell carcinoma, Published online: 17 October 2018; doi:10.1038/s41416-018-0175-xCombination VEGFR/immune checkpoint inhibitor therapy: a promising new treatment for renal cell carcinoma
A prediction model for underestimation of invasive breast cancer after a biopsy diagnosis of ductal carcinoma in situ: based on 2892 biopsies and 589 invasive cancers, Published online: 17 October 2018; doi:10.1038/s41416-018-0276-6A prediction model for underestimation of invasive breast cancer after a biopsy diagnosis of ductal carcinoma in situ: based on 2892 biopsies and 589 invasive cancers
Editor ’s PerspectiveWhat We Already Know about This TopicDexmedetomidine reduces cellular apoptosis, and it has been demonstrated previously that this antiapoptotic effect can not only increase cancer cell proliferation and migration but also reduce survival in experimental models of cancer growth.Midazolam has proapoptotic effects and can reduce cancer cell survival. The mechanisms by which midazolam suppresses cancer cell progression remain to be defined.What This Article Tells Us That Is NewAs expected, dexmedetomidine enhanced cancer cell proliferation and migration, primarily by the upregulation of antiapoptoti...
Editor ’s PerspectiveWhat We Already Know about This TopicPropofol may better preserve host defenses against cancerWhether cancer recurrence is less likely with propofol than volatile anesthesia remains unknownWhat This Article Tells Us That Is NewThe authors conducted a propensity-matched retrospective analysis of 1,158 patients who had colon cancer surgeryPatients anesthetized with propofol had better overall survivalBackground Previous research has shown different effects of anesthetics on cancer cell growth. Here, the authors investigated the association between type of anesthetic and patient survival after elect...
Conclusion: This study unveils a potential function of Gab2 in HER2-overexpressing breast cancer cells. Gab2 might be a potential target in the clinical therapy of HER2-overexpressing breast carcinoma.Cell Physiol Biochem 2018;50:52 –65
Several factors underlie a profound reduction in the HIV-1 reservoir in patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) for hematologic disease, researchers report.Reuters Health Information
Authors: Quicios-Dorado C, Bolufer-Moragues E, Gomis-Goti C, Cabello-Benavente R, Cannata-Ortiz PJ, González-Enguita C Abstract Castration resistant prostate cancer (CRPC) is characterized by an important molecular, pathological and clinical heterogeneity. Although most of them present androgen receptor (AR) signal dependence, there are independent phenotypes. Neuroendocrine prostate cancer (NEPC) is a rare histologic subtype with adverse prognosis due to late diagnosis, heterogeneous clinical features and lack of effective systemic treatments. Platinum based chemotherapy is the standard treatment, presentin...
CONCLUSIONS: Abiraterone acetate is a new hormonal treatment for metastatic castration resistant prostate cancer both before and after chemotherapy. The results of the available studies demonstrate a significant improvement in terms of efficacy, with a tolerability profile generally acceptable, predictable and manageable, and an improvement in patient's perceived quality of life. PMID: 30319125 [PubMed - in process]
In this study, the distribution and transformation of Se and I species were investigated in radish seedlings that were simultaneously supplemented with these two elements; the fate and the bioaccessibility of Se and I species were dynamically surveyed in the oral, gastric and intestinal phases using a simulated in vitro digestion method. The radish seedlings were cultivated in hydroponic conditions with Se (IV), Se (VI), I− and IO3− (each 1 mg L−1). The results revealed that Se-methylselenocysteine (MeSeCys), selenocystine (SeCys2), selenomethionine (SeMet) and Se (VI) were present in radish, and MeSe...
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