Nanotechniques Inactivate Cancer Stem Cells.

In this study, the ability of synthesized hybrid nanocomplexes, comprising the nanoparticles of rare earth orthovanadates GdYVO4:Eu(3+) and cholesterol to inhibit the tumor growth and to increase the survival of the animals with tumors was established. A special contribution into tumor-inhibiting effect is made by each of its components. Treatment of Ehrlich carcinoma cells with two-component hybrid complex resulted in maximum reduction in the concentration of the most tumorigenic CD44(high) cells with simultaneous rise in the number of CD117(+) cells that decreased an intensity of tumor growth by 74.70 ± 4.38% if compared with the control.
PMID: 28622715 [PubMed - in process]

Source: Cancer Control - June 18, 2017 Category: Cancer & Oncology Authors: Goltsev AN, Babenko NN, Gaevskaya YA, Bondarovich NA, Dubrava TG, Ostankov MV, Chelombitko OV, Malyukin YV, Klochkov VK, Kavok NS Tags: Nanoscale Res Lett Source Type: research