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Carrie Fisher's Autopsy Findings Point Out Links Between Sleep Apnea And Drug Use, Heart Disease

Carrie Fisher's autopsy findings raise questions about the interplay of sleep apnea, drug use and heart disease.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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Authors: Aboussouan LS, Golish JA, Wood BG Abstract Preview Repeated occlusion of the upper airway during sleep results in the obstructive sleep apnea syndrome. Affected individuals may experience excessive daytime sleepiness, intellectual impairment, and personality changes, and their risk of cerebrovascular accidents, ischemic heart disease, and severe respiratory failure is increased. The authors of this article examine methods of recognizing the disorder, indications for treatment, and various medical and surgical approaches to management. PMID: 29211558 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Conclusions: This meta-analysis of prospective cohort studies suggests that OSA significantly increases the risk of CHD, stroke and CCVD in Chinese population.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Others Source Type: research
Conclusion: The present study suggests that in young patients with OSA without known CVD, CACS may overcome the risk underestimation of classical FRS. Using CACS≥75th percentile may contribute to more individual approach to these patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and Control of Breathing Source Type: research
We describe comorbidity, analytical, functional and radiological data and mortality.Results: We study 31 patients, 11 males, age of 70 ± 9.4 years, 18/31 were former or smokers. RA was diagnosed 7,9 ± 8,6 years before the ILD. ILD was diagnosed before RA in 10%. The BMI was 27 ± 4. Rheumatoid factor (RF) and anti-ccp were positive in 86% (25/29) and 77% (20/26) with median values of 280 ± 376 and 751 ± 821. One patient had both antibodies negative. CRP and the ESR median values were 2.5 ± 6.6 and 42 ± 23, respectively. Concomitant diseases were, 19/31 (61%) hypertension, 5/3...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Diffuse Parenchymal Lung Disease Source Type: research
(Northwestern University) A synthetic cannabis-like drug in a pill reduced apnea and daytime sleepiness in the first large multi-site study of a drug for apnea. The drug targets the brain in a new treatment strategy. There is currently no drug treatment for sleep apnea, a sleep breathing disorder affecting about 30 million individuals in the US. Untreated apnea raises the risk of heart disease, diabetes, sleepiness, cognitive impairment and a motor vehicle accident.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
We present the anesthetic management for a 2-year old with Down syndrome and complex cyanotic congenital heart disease undergoing tonsillectomy and adenoidectomy for severe obstructive sleep apnea.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports: Case Report Source Type: research
AbstractAdults with congenital heart disease (CHD) are a rapidly increasing population and their impact on healthcare resources is not fully understood. The purpose of this study was to describe the costs of hospitalizations for non-cardiac disease for adults with CHD. We conducted a retrospective review of hospital discharge data from the University HealthSystem Consortium Clinical Data Base/Resource Manager from January 2011 through December 2013. Patients were  ≥ 18 years old at admission with any ICD-9 code for moderate or high severity CHD; cardiac surgical admissions were excluded. The comparison gr...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
Conclusions:The median score for cognitive, language, and motor scores for preterm infants with neonatal OSA were within one standard deviation of the published norm. Mean end-tidal CO2, independent of AHI, may serve as a biomarker for predicting poor cognitive outcome in preterm infants with neonatal OSA.Commentary:A commentary on this article appears in this issue on page 1233.Citation:Bandyopadhyay A, Harmon H, Slaven JE, Daftary AS. Neurodevelopmental outcomes at two years of age for premature infants diagnosed with neonatal obstructive sleep apnea.J Clin Sleep Med. 2017;13(11):1311–1317.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
The Growing Toll of Our Ever-Expanding WaistlinesBy  JANE E. BRODY NOV. 13, 2017Paul Rogers I hope you ’re not chomping on a bagel or, worse, a doughnut while you read about what is probably the most serious public health irony of the last half century in this country: As one major killer — smoking — declined, another rose precipitously to take its place: obesity.Many cancer deaths were averted after millions quit lighting up, but they are now rising because even greater numbers are unable to keep their waistlines in check.Today, obesity and smoking remain the two leading causes of pre...
Source: Dr Portnay - Category: Cardiology Authors: Source Type: blogs
Adults with Down syndrome (DS) represent a unique population who are in need of clinical guidelines to address their medical care. The United States Preventive Service Task Force (USPSTF) has developed criteria for prioritizing conditions of public health importance with the potential for providing screening recommendations to improve clinical care. The quality of existing evidence needed to inform clinical guidelines has not been previously reviewed. Using the National Library of Medicine (NLM) database PubMed, we first identified 18 peer reviewed articles that addressed co‐occurring medical conditions in adults with DS...
Source: American Journal of Medical Genetics Part A - Category: Genetics & Stem Cells Authors: Tags: RESEARCH REVIEW Source Type: research
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