Baseline characteristics predicting very good outcome of allogeneic Hematopoietic Cell Transplantation in young high cytogenetic risk Chronic Lymphocytic Leukemia patients - a retrospective analysis from the Chronic Malignancies Working Party of the EBMT

CLL patients with del(17p) or del(11q) have poor long-term prognosis with targeted therapies. Conversely, this retrospective EBMT registry study shows that young high cytogenetic risk responsive patients with HLA-matched donors have a high 8-year progression-free-survival and low 2-year non-relapse mortality after allogeneic stem cell transplantation. This treatment then may compare favorably with targeted therapies for younger high cytogenetic risk patients.

Source: Clinical Lymphoma, Myeloma and Leukemia - June 16, 2017 Category: Hematology Authors: Michel van Gelder, Dimitris Ziagkos, Liesbeth de Wreede, Anja van Biezen, Peter Dreger, Martin Gramatzki, Matthias Stelljes, Niels Smedegaard Andersen, Nicolaas Schaap, Antonin Vitek, Dietrich Beelen, Vesa Lindstr öm, Jürgen Finke, Jacob Passweg, Matthi Tags: Original Study Source Type: research