Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation
Conclusions:
Myocardial copper deficiency and defective cellular copper transport/trafficking are revealed as key molecular defects underlying LV impairment in diabetes, and TETA-mediated restoration of copper regulation provides a potential new class of therapeutic molecules for DCM.
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Shaoping ZhangHong LiuGreeshma AmarsinghCarlos CheungSebastian HoglUmayal NarayananLin ZhangSelina McHargJingshu XuDeming GongJohn KennedyBernard BarryYee ChoongAnthony PhillipsGarth Cooper Source Type: research
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