Study Cites Top Reasons Young Autism Patients Are Hospitalized

Mood disorders, sleep problems and having a single caregiver raise odds of in - patient psychiatric care
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Neurology, Nursing, Pediatrics, Psychiatry, News, Source Type: news

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Publication date: Available online 22 May 2018 Source:Neuroscience Author(s): Christine E. Boone, Heydar Davoudi, Jon B. Harrold, David J. Foster Fragile X syndrome (FXS) is the most common heritable cause of intellectual disability and single-gene cause of autism spectrum disorder. The Fmr1 null mouse models much of the human disease including hyperarousal, sensory hypersensitivity, seizure activity, and hippocampus-dependent cognitive impairment. Sleep architecture is disorganized in FXS patients, but has not been examined in Fmr1 knockout (Fmr1-KO) mice. Hippocampal neural activity during sleep, which is implicated in ...
Source: Neuroscience - Category: Neuroscience Source Type: research
Abstract De novo variants of ASH1L, which encodes a histone methyltransferase, have been reported in a few patients with intellectual disability and autistic features. Here, we identified a novel de novo frame-shift variant, c.2422_2423delAAinsT which predicts p.(Lys808TyrfsTer40), in ASH1L in a patient with multiple congenital anomalies (MCA), fine motor developmental delay, learning difficulties, attention deficit hyperactivity disorder, sleep apnea, and scoliosis. This frame-shift variant is expected to result in loss-of-function. Our report provides further evidence to support loss-of-function alterations of A...
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
CONCLUSIONS: This study suggests that amantadine may be effective in the treatment of ESES-associated syndromes but warrants replication in a more rigorous study. PMID: 29754107 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
ConclusionsWe demonstrate two quantitative readouts of dysregulated sleep composition in children with AS —gamma coherence and spindles—and describe how functional connectivity patterns may be disrupted during wakefulness. Quantitative EEG phenotypes have potential as biomarkers and readouts of target engagement for future clinical trials and provide clues into how neural circuits are dysregulated i n children with AS.
Source: Molecular Autism - Category: Molecular Biology Source Type: research
Publication date: 18 April 2018 Source:Neuron, Volume 98, Issue 2 Author(s): Alexandra Krol, Ralf D. Wimmer, Michael M. Halassa, Guoping Feng Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are based on symptomatic descriptions that have been difficult to connect to mechanism. Although psychiatric genetics provide insight into the genetic underpinning of such disorders, with a majority of cases explained by polygenic factors, it remains difficult to design rational treatments. In this review, we highlight the value of understanding neural circuit function both as an intermediate level ...
Source: Neuron - Category: Neuroscience Source Type: research
Happy Saturday, sweet readers! Did everyone survive yesterday? Or did you even realize it was Friday 13th? Honestly, I didn’t remember until around noon yesterday. To quote the great Michael Scott, “I’m not superstitious, but I am a little stitious.” In other words, I didn’t wake up and begin anxiously awaiting doom around every corner, but, once I did remember what day it was…I kept an eye open. It’s only human nature. Anyway, let’s get on with everything this week’s Psychology Around the Net has to offer which includes science-backed ways to boost creativity, how to ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Alzheimer's Bipolar Celebrities Children and Teens College Creativity Disorders Happiness Phobia Psychology Around the Net Research Sleep Women's Issues Alzheimer's disease Bipolar Disorder brain Creative Thinking Embarra Source Type: blogs
Genetic studies point to the thalamic reticular nucleus (TRN) in the pathogenesis of ASD. The TRN modulates sensory processing and attention by gating thalamocortical communication during wake, and propagates spindles during sleep (oscillations critical for memory consolidation). Here, we investigated whether thalamocortical functional connectivity is abnormal in ASD. Because motion artifacts may create spurious group differences, we used pre-scan training and strict data quality inclusion criteria to prevent and control for motion confounds.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
We present the case of a 12-year-old child with atypical autism who developed psychotic symptoms that led to a diagnostic dilemma. Proper exploration of early childhood history, prompt treatment with an antipsychotic medication, and social skill training led to resolution of psychotic symptoms and improvement in disruptive symptoms of autism. Keywords: Autism, psychosis, association, autism spectrum disorder, ASD Since the concept of psychosis by Blueler 1 and Kraeplin2 first emerged, autism spectrum disorder (ASD) was thought to be an early manifestation of psychosis or schizophrenia, and ASD in children was referred as &...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue ASD association autism autism spectrum disorder psychosis Source Type: research
Kudos to Nicole Archambault for her highly informative and well-documented article on sleep, airway function and the effect of sleep-disordered breathing on our children (“Healthy Breathing, ’Round the Clock,” February 2018). The impact of airway-function disorders (AFDs) cannot be overstated. The high percentages of comorbidity between AFD and sleep disorders, autism, learning disability, ADHD, and speech-language and swallowing difficulties are shocking. Who knew?
Source: The ASHA Leader Online - Category: Speech-Language Pathology Source Type: research
Children with neurodevelopmental disorders (NDD) are at high risk for sleep problems, especially insomnia. It is currently not known whether behavioural sleep interventions developed for typically developing (TD) children are effective for children with NDD, and if interventions need to be modified for each diagnostic group. The aim of this systematic review was to identify and evaluate commonalities, trends in outcomes, and the methodological quality of parent-delivered behavioural sleep interventions for children with NDD, specifically Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Cereb...
Source: Sleep Medicine Reviews - Category: Sleep Medicine Authors: Tags: Clinical Review Source Type: research
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