Concentrations of Pneumococcal IgA and IgM are compromised in some individuals with antibody deficiencies.

Concentrations of Pneumococcal IgA and IgM are compromised in some individuals with antibody deficiencies. J Immunoassay Immunochem. 2017 Jun 15;: Authors: Echeverría de Carlos A, Gómez de la Torre R, García Carus E, Caminal Montero L, Bernardino Díaz López J, Suárez Casado H, Molinos Matin L, Tricas Aizpún L, Harding S, Parker AR Abstract The response to pneumococcal vaccination is assessed by measurement of antigen specific IgG only and is compromised in a number of antibody deficiencies. We measured the concentrations of Pneumococcal IgA and IgM in individuals with both normal and abnormal pneumococcal capsular polysaccharide (PCP) IgG concentrations. A higher number of individuals had abnormal pre vaccination IgA and IgM concentrations below the lower limit of the normal range compared to the control group. Post vaccination a lower number of individuals had IgA and IgM concentrations below the upper limit of the normal range compared to the control group. Non responders had a higher percentage of individuals with a prior history of infection. In addition, individuals with a history of prior infection had lower pre and post vaccination concentrations of PCP IgG, IgA, and IgM. Post vaccination IgA and IgM concentrations identified four groups of responses which correlated with prior history of infection. A higher percentage of individuals with abnormal PCP IgA and IgM concentrations had a history of prior infection compared ...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research