Mesothelioma Clinical Trial Opens with High Expectations

Newly diagnosed mesothelioma patients around the world have begun enrolling in a much-anticipated, phase III clinical trial involving an immunotherapy drug combination with groundbreaking potential. The trial, designed as first-line therapy for unresectable pleural mesothelioma, will measure the effectiveness of nivolumab (Opdivo) and ipilimumab (Yervoy) against standard-of-care chemotherapy. A presentation this month at the 2017 American Society of Clinical Oncology (ASCO) annual meeting sparked high expectations for the trial, detailing early, impressive effectiveness involving the two drugs in second-line and third-line treatments. Pharmaceutical giant Bristol-Myers Squibb is sponsoring the latest clinical trial that will include investigational sites in 20 countries and 17 cancer centers across the U.S., including: Moffitt Cancer Center in Tampa, Florida WVU Mary Babb Randolph Cancer Center in Morgantown, West Virginia University of Chicago Cancer Center Abramson Cancer Center in Philadelphia Mayo Clinic in Rochester, Minnesota Smilow Cancer Hospital in New Haven, Connecticut Cleveland Clinic Cancer Center “We’re ultimately hoping [with this trial] to forge a new standard of care for mesothelioma,” Dr. Patrick Ma, lead investigator at WVU Cancer Center, told Asbestos.com. “Yes, the expectations for this trial are high.” Previous Results Are Impressive The ASCO presentation in Chicago was based on a multi-center phase II trial in France t...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Abramson Cancer Center American Society of Clinical Oncology Bristol-Myers Squibb cancer immunotherapy research cisplatin for mesothelioma Cleveland Clinic Cancer Center CRS-207 disease control rate Dr. Arnaud Scherpereel Dr. Patrick Ma Source Type: news

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Molecular Mechanisms of Notch Signaling in Lymphoid Cell Lineages Development: NF-κB and Beyond. Adv Exp Med Biol. 2020;1227:145-164 Authors: Tsaouli G, Barbarulo A, Vacca A, Screpanti I, Felli MP Abstract Notch is a ligand-receptor interaction-triggered signaling cascade highly conserved, that influences multiple lineage decisions within the hematopoietic and the immune system. It is a recognized model of intercellular communication that plays an essential role in embryonic as well as in adult immune cell development and homeostasis. Four members belong to the family of Notch receptors (Notch1-4...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Aradhya R, Jagla K Abstract Notch plays multiple roles both in development and in adult tissue homeostasis. Notch was first identified in Drosophila in which it has then been extensively studied. Among the flag-ship Notch functions we could mention its capacity to keep precursor and stem cells in a nondifferentiated state but also its ability to activate cell proliferation that in some contexts could led to cancer. In general, both these functions involve, canonical, ligand-dependent Notch activation. However, a ligand-independent Notch activation has also been described in a few cellular contexts. Here, w...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Salviano-Silva A, Berti FCB, Lobo-Alves SC, de Araujo-Souza PS, Boldt ABW, Malheiros D Abstract The Notch signaling is a crucial pathway involved in cellular development, progression, and differentiation. Deregulation of Notch signaling pathway commonly impacts tissue homeostasis, being highly associated with proliferative disorders. The long noncoding RNAs (lncRNAs), which are transcripts with more than 200 nucleotides that do not code for proteins, were already described as Notch signaling pathway-interacting molecules. Many of them act as important transcriptional and posttranscriptional regulators, aff...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: McIntyre B, Asahara T, Alev C Abstract Notch signaling is an evolutionarily conserved pathway associated with the development and differentiation of all metazoans. It is needed for proper germ layer formation and segmentation of the embryo and controls the timing and duration of differentiation events in a dynamic manner. Perturbations of Notch signaling result in blockades of developmental cascades, developmental anomalies, and cancers. An in-depth understanding of Notch signaling is thus required to comprehend the basis of development and cancer, and can be further exploited to understand and direct the ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Reichrath J, Reichrath S Abstract Evolutionary conserved Notch signaling is of high importance for embryogenesis and adult tissues, representing one of the most fascinating pathways that regulate key cell fate decisions and other core processes. This chapter gives a short introduction to the first volume of the book entitled Notch Signaling in Embryology and Cancer, that is intended to provide both basic scientists and clinicians who seek today`s clearest understanding of the molecular mechanisms that mediate Notch signaling with an authoritative day-to-day source. On a first look, Notch signaling, that fi...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Too often I feel like as pre-dentals all we worry about are how high our stats are, how much we impact others, and if getting into dental school is even possible. Our lives revolve around helping others, however what do we do when we need to help ourselves? I've spent the last 4 years of college trying to make a difference in my community; caring about the well-being of others. Recently my father was diagnosed with cancer and I do not know how to cope with it. Mentally I have been... Dealing with adversity...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Dental Source Type: forums
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): B. Choi, H. Jung, B. Yu, H. Choi, J. Lee, D. Kim
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): R. Alhalawani, R. Sheth, S. Yevich
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): Y. Wang, K. Schachtschneider, Y. Huang, R. Gaba, P. Nguyen, P. Yen, M. Sverdlov, G. Guzman, R. Lokken
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): F. Zhang, S. Gao, X. Yang
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
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