Optellum unveils lung cancer analysis software
Artificial intelligence software developer Optellum said it will showcase a...Read more on AuntMinnie.com
In conclusion, salidroside inhibited the survival, migration and invasion of NSCLC cells. Salidroside blocked AKT and the MEK/ERK signal pathway by upregulating miR-195 expression in A549 cells. PMID: 30880481 [PubMed - in process]
Volume 47, Issue 1, December 2019, Page 1014-1021 .
In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f. PMID: 30873868 [PubMed - in process]
Volume 47, Issue 1, December 2019, Page 810-821 .
WEDNESDAY, March 13, 2019 -- The term artificial intelligence (AI) might bring to mind robots or self-driving cars. But one group of researchers is using a type of AI to improve lung cancer screening. Screening is important for early diagnosis and...
Conclusion.The use of agents that act on the PD‐L1 pathway are contraindicated in the face of solid organ allografts because of unacceptably high rates of irreversible allograft rejection. It appears that the use of ipilimumab may be tolerated as the mechanism is different from that of the PD‐L1 agents.Implications for Practice.Transplant rejection is a complex process that puts stress on patients and their families and can lead to tragic results. Significant advancements in the field of immunosuppression have led to the engenderment of agents devised to extend the survival of transplant recipients. The advent of immun...
We report the case of a patient with ALK translocated ALCL with CNS involvement who developed debilitating neuropathy after chemotherapy and was treated with alectinib at relapse. The patient had a complete response after 6 weeks which has continued for 6 months allowing him to undergo an allogeneic stem cell transplant. To our knowledge, this is the first published case report of a patient with ALCL successfully treated with alectinib.
(University of Pittsburgh) Right now, 96 percent of people who screen positive for lung cancer don't actually have a malignant growth. Machine learning can rule out cancer in a third of them, saving time, money and anxiety.
In this study, we, first, confirmed that LUCAT1 acted as an up-regulated lncRNA by analyzing the data from GCTA dataset and RT-PCR in both CC tissues and cell lines. We also showed that TINCR overexpression is induced by nuclear transcription factor SP1. Then, clinical assays showed that LUCAT1 was associated with advanced clinical progression and poor prognosis of CC patients. Importantly, multivariate Cox model confirmed that LUCAT1 expression was an independent prognostic factor for both 5-year overall survival in CC. Then, lost-function assays revealed that knockdown of LUCAT1 significantly suppressed CC cells prolifer...
CONCLUSIONS: Both cancer incidence and mortality are remarkably increased after heart transplantation, with the relative incidence most elevated for SCC, lip and other oral cancers, and for NHL. PMID: 30821595 [PubMed - as supplied by publisher]