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Heroin Addiction: How My Father Saved Me

I was a breech birth ― feet first, my head got stuck in the birth canal. My father brought me to Children’s Hospital in Boston. The doctors diagnosed me with Cerebral Palsy. They told him that the loss of oxygen to my brain had destroyed a portion of the frontal lobe. But my father was a tough Irish Catholic, old-school warrior. He refused to listen to them. No son of his was going to be a cripple. He found a doctor that told him how he could take the place of my injured brain. Every day, he laid me on the floor and exercised my legs. The muscles in my right leg were all shrunken and twisted. His job was to straighten them. Back and forth, up and down, he stretched them until the heels of my feet evenly matched. My mother told me the sound of me screaming was so unbearable that the neighbors called the police. She said he couldn’t look at me. She told me how his tears made wet stains on my little T-shirt. For my 13th birthday, he threw me a party and allowed me to open every present but a large box neatly trimmed in wrapping paper. When everybody left, he marched me into the basement to open the box. A pair of boxing gloves. We put them on, and he beat me unmercifully. Each time I tried to get up, he’d knock me down. I begged him to stop. Instead, he picked a target on my face, never once missing the bull’s eye. When I collapsed, he cradled me and said, “I’d cut off my right arm if that would make you whole.” My father believed that...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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To the Editor: We read with interest the letter by Drago et  al1 responding to our article on alcohol intake and increased risk for rosacea.2 On the basis of the positive association between rosacea and small intestinal bacterial overgrowth (SIBO) in their prior study, Drago et al examined alcohol intake as a risk factor for SIBO in rosacea patients in a c ase-control study.1 The authors propose that ethanol causes achlorhydria and decreased intestinal motility, which favor the proliferation of luminal bacteria, leading to SIBO.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD online Source Type: research
To the Editor: A frontal band of scarring alopecia with eyebrow involvement in postmenopausal women (ie, frontal fibrosing alopecia [FFA]) evolved from a “recently described disease” to the status of “a growing epidemic” in less than 2 decades. Since the first report by Kossard,1 additional features and variants not contemplated in the original description have been incorporated into the clinical picture. For such, I read with great interest the paper by Rossi et al reporting 3 unusual clinical patterns of FFA.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD online Source Type: research
The metabolic syndrome represents an important association of cutaneous maladies with cardiovascular illnesses. Chronic inflammation, shared risk factors (ie, smoking and alcohol consumption), treatment (ie, immunosuppressive agents and drugs that alter the lipid profile), and shared genetic risk loci have been proposed to the cause metabolic syndrome and cardiovascular morbidity of autoimmune diseases. There are many possible inflammatory mediators that are suggested to play a role in insulin resistance pathogenesis, such as tumor necrosis factor- α, interleukin-6, leptin, and adiponectin.
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research
Acne vulgaris is an epidemic inflammatory disease of the human sebaceous follicle and represents the most common skin disease affecting about 85% of adolescents in Westernized populations. Acne vulgaris is primarily a disease of wealthy countries and exhibits higher prevalence rates in developed compared with developing countries. No acne has been found in non-Westernized populations still living under Paleolithic dietary conditions constraining hyperglycemic carbohydrates, milk, and dairy products.
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research
The metabolic syndrome (MetS), also termed syndrome X, the deadly quartet, and insulin resistance syndrome, has been of interest for many years; however, there has been a striking increase in the prevalence of MetS over the last few decades, coinciding with the global epidemic of obesity and diabetes mellitus.1,2 MetS is a constellation of several clinical and laboratory findings that have been reported to be associated with numerous medical and dermatologic conditions, such as psoriasis, hidradenitis suppurativa, and acne vulgaris; moreover, the severity of psoriasis is significantly associated with MetS at higher psorias...
Source: Clinics in Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
Lisa Mailleux, Cristina Simon-Martinez, Katrijn Klingels, Ellen Jaspers, Kaat Desloovere, Philippe Demaerel, Simona Fiori, Andrea Guzzetta, Els Ortibus, Hilde Feys
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Authors: Kar SK, Dwivedi S PMID: 29223831 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Alcohol is a diuretic, forcing water out of body and making it harder to rehydrate. It can cause skin to look sallow and make fine lines and pores more pronounced.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
We present here the proceedings of the 5th seminar on emerging infectious diseases, held in Paris on March 22nd, 2016, with seven priority proposals that can be outlined as follows: encourage research on the prediction, screening and early detection of new risks of infection; develop research and surveillance concerning transmission of pathogens between animals and humans, with their reinforcement in particular in intertropical areas ("hot-spots") via public support; pursue aid development and support in these areas of prevention and training for local health personnel, and foster risk awareness in the population...
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
Oncogenic addiction to the Fms-like tyrosine kinase 3 (FLT3) is a hallmark of acute myeloid leukemia (AML) that harbors the FLT3–internal tandem duplication (FLT3-ITD) mutation. While FLT3 inhibitors like sorafenib show initial therapeutic efficacy, resistance rapidly develops through mechanisms that are incompletely understood. Here, we used RNA-Seq–based analysis of patient leukemic cells and found that upregulation of the Tec family kinase BMX occurs during sorafenib resistance. This upregulation was recapitulated in an in vivo murine FLT3-ITD–positive (FLT3-ITD+) model of sorafenib resistance. Mechani...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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