Is a new flu pandemic just three mutations away?

Conclusion This laboratory study analysed an H7N9 strain of bird flu. Researchers wanted to explore whether a particular change to the surface proteins of a virus was capable of allowing the strain to bind to human tissue. This would theoretically lead to human-to-human transmission of the flu virus. It is worth noting that this ability to attach to human cells does not necessarily mean a mutated bird flu virus will be able to infect, replicate and transmit between humans. Other changes would also be required. However, they were unable to further investigate whether this surface change could lead to human-to-human transmission of the virus because this type of experiment is not permitted under US law. This research attracted the attention of several experts in the field. Dr Fiona Culley, spokesperson for the British Society for Immunology, &Senior Lecturer in Respiratory Immunology at Imperial College London commented: "This is a good, thorough study which specifically aimed to identify which changes in bird flu would allow the virus to attach to human cells." "The authors found that certain combinations of three mutations were needed for the bird flu to be able to attach to human lung cells. They could potentially happen, but there is currently no evidence that they have ever occurred and the chances of all three occurring together is relatively low." Links To The Headlines Just THREE mutations are needed to make bird flu a potential pandemic strain ...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

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China reported a new H5N6 bird flu outbreak in the southwestern province of Yunnan, the agriculture ministry said on Friday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Since the beginning of the year, more than 160 people have contracted the virus, which was spread through a religious group and a Valentine ’ s Day gift fair.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Measles Vaccination and Immunization Japan Source Type: news
[The Conversation Africa] The first case of Lassa fever in Nigeria was recorded in 1969. A zoonotic disease endemic to West Africa, the disease was named after the town in Nigeria where the first case occurred.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Hero ínas de la vida real: Adamari López aprendió a escuchar a su cuerpo ... Está en camino a la recuperación después de una peligrosa influenza que casi le roba la vida. ... por: Jennifer García Ca...
Source: News - Category: American Health Source Type: news
Between January and May in 2018, 17 male cases of hepatitis A were reported in Yokohama, Japan. Of these, 14 identified as men who have sex with men. The viral sequence in this outbreak was same as that of the recent European and Taiwanese outbreaks strain.
Source: Sexually Transmitted Diseases - Category: Sexual Medicine Tags: Case Report Source Type: research
Conclusion: Rheumatology and internal medicine patients, including patients treated with methotrexate without corticosteroids, are at risk of developing chronic HEV infection. Rheumatology and internal medicine patients with abnormal liver tests should be screened for HEV infection.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
This study aims to describe the spatial and temporal characteristics of human infections with H7N9 virus in China using data from 19 February 2013 to 30 September 2017 extracted from Centre for Health Protection of the Department of Health (CHP) and electronic databases managed by China’s Center for Disease Control (CDC) and provincial CDCs synthetically using the Geographic Information System (GIS) software ArcMap™ 10.2 and SaTScan. Based on the multiple analyses of the A(H7N9) epidemics, there was a strong seasonal pattern in A(H7N9) virus infection, with high activity in the first quarter of the year...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractThe synaptonemal complex is an evolutionarily conserved, supramolecular structure that holds the homologous chromosomes together during the pachytene stage of the first meiotic prophase. Among vertebrates, synaptonemal complex dynamics has been analyzed in mouse spermatocytes following the assembly of its components from leptotene to pachytene stages. With few exceptions, a detailed study of the disassembly of SCs and the behavior of SC components at recombination sites at the onset of diplotene has not been accomplished. Here, we describe for the first time the progressive disassembly of the SC in chicken oocytes ...
Source: Chromosoma - Category: Genetics & Stem Cells Source Type: research
BOSTON (CBS) – Routine childhood vaccines are required to stay in school, but more and more parents are opting out for what they call personal or religious reasons. Now, the head of the FDA says the federal government may have to step in if states don’t strengthen their vaccine laws. Seventeen states allow families to skip vaccines for personal beliefs. Forty-seven states, including Massachusetts, allow religious exemptions. A child gets a vaccine. (WBZ-TV photo) As a result, we’re seeing outbreaks of potentially deadly diseases that were once eradicated, like measles. In fact, there have been at least 12...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local Dr. Mallika Marshall FDA Vaccines Source Type: news
ConclusionsOccupational health procedures were enhanced, staff were screened, and antibiotic therapy was provided to GAS-positive staff and patients. The definitive source of infection could not be identified, although staff–patient transmission was the most likely route. The pattern of clonal GAS transmission over the four-year study period suggests that long-term persistence of GAS may have occurred.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
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