Is a new flu pandemic just three mutations away?

Conclusion This laboratory study analysed an H7N9 strain of bird flu. Researchers wanted to explore whether a particular change to the surface proteins of a virus was capable of allowing the strain to bind to human tissue. This would theoretically lead to human-to-human transmission of the flu virus. It is worth noting that this ability to attach to human cells does not necessarily mean a mutated bird flu virus will be able to infect, replicate and transmit between humans. Other changes would also be required. However, they were unable to further investigate whether this surface change could lead to human-to-human transmission of the virus because this type of experiment is not permitted under US law. This research attracted the attention of several experts in the field. Dr Fiona Culley, spokesperson for the British Society for Immunology, &Senior Lecturer in Respiratory Immunology at Imperial College London commented: "This is a good, thorough study which specifically aimed to identify which changes in bird flu would allow the virus to attach to human cells." "The authors found that certain combinations of three mutations were needed for the bird flu to be able to attach to human lung cells. They could potentially happen, but there is currently no evidence that they have ever occurred and the chances of all three occurring together is relatively low." Links To The Headlines Just THREE mutations are needed to make bird flu a potential pandemic strain ...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

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CONCLUSIONS: YF acute severe cases show a generalised involvement of different organs (liver, spleen, heart, kidneys, intestines and pancreas), and different parameters were related to outcome. Factor V and lipase are independent variables associated with death, reinforcing the importance of hemorrhagic events due to fulminant liver failure and pointing to pancreatitis as a relevant event in the outcome of the disease. PMID: 31116245 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
This study aimed to produce and fractionate IgY antibodies from the egg yolks of hens that were immunized with the total antigenic extracts of Strongyloides venezuelensis infectious filariform larvae (iL3) and parthenogenetic females (pF). IgY antibodies were then evaluated by their recognition of antigenic proteins, evolutive helminth forms, and serological diagnosis of human strongyloidiasis by the detection of immune complexes in serum samples. Egg yolks were fractionated to obtain IgY antibodies by thiophilic interaction chromatography. Immune complex detection in serum samples showed diagnostic values for anti-iL3 IgY...
Source: Parasitology International - Category: Parasitology Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Theoretical BiologyAuthor(s): Shing Hei Ho, Daihai He, Raluca EftimieAbstractTwo mathematical models described by simple ordinary differential equations are developed to investigate the Hong Kong influenza epidemic during 2017 - 2018 winter, based on overall epidemic dynamics and different influenza subtypes. The first model, describing the overall epidemic dynamics, provides the starting data for the second model which different influenza subtypes, and whose dynamics is further investigated. Weekly data from December 2017 to May 2018 are obtained from the da...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Research from Queen Mary University in London found doctors were seeing Spanish flu for years before it exploded into a pandemic which infected a third of the world's population.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The CDC operates a Do Not Board list to prevent people believed to be a public health risk from getting on planes.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
We report three cases of severe Enterovirus-71 neurological disease treated with plasma exchange during an outbreak in Catalonia (Spain) in 2016. We observed a striking improvement in all three patients within 48 hours of starting plasma exchange. Patients received four to six sessions every other day. Good outcomes were confirmed at the one-year follow-up visit. Our observations suggest that plasma exchange is an effective complementary therapy for severe Enterovirus-71 neurological disease.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, we applied the Protection Motivation Theory to identify factors influencing farmer intention to undertake biosecurity management strategies. A survey was carried out between 2015 and 2016 across 101 Vietnamese farmers in three locations in Australia: the Northern Territory, South Australia, and Western Australia. Following data analysis using factor analysis and stepwise regressions, the results showed that farmer self-efficacy of on-farm risk management strategies, available incentives, and belief in biosecurity threats associated, positively, with the intention to adopt biosecurity risk management strategi...
Source: The Social Science Journal - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 22 May 2019Source: Microbial PathogenesisAuthor(s): Jing Zhao, Changqing Liu, Jiaojiao Zhang, Xiuying Huang, Guozhong ZhangAbstractTo investigate cytokine expression in chicken embryo fibroblast (CEF) cells, a virulent avian avulavirus 1 (AAvV-1) strain called SG10 that rapidly causes 100% mortality in its host, and a vaccine strain (La Sota) were characterized. Real-time quantitative PCR was performed on RNA samples from CEF cells, which were collected at 0, 24, 48 and 72 h post-infection. The dynamic expression patterns of ten cytokines (TNF-α, IFN-α, IFN-β, IL-1&beta...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
With the Democratic Republic of the Congo ’s worst ever Ebola outbreak now in its tenth month, the United Nations on Thursday announced measures to strengthen its response, with the Organization’s newly appointed Emergency Coordinator (EERC) declaring there is “no time to lose”.
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
As a medical student, the place I dreaded most was the ward at the children’s hospital where they kept the chronic ventilator patients. Unlike the other floors, where there was shouting and laughter and tears, and all the commotion and turbulence of youth, here it was dark and lifeless and eerie, with no sound except the hum of the ventilators, and the rattle of air being forced through plastic tubes. It was a place of failure and defeat, the desolate aftermath of some vast and tragic battle. An unexpected aftermath of measles My patient was a teenager who had been in a coma for years. His limbs had stubbornly twiste...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Children's Health Infectious diseases Men's Health Vaccines Women's Health Source Type: blogs
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