Metabolic reprogramming in clear cell renal cell carcinoma

Nature Reviews Nephrology 13, 410 (2017). doi:10.1038/nrneph.2017.59 Authors: Hiromi I. Wettersten, Omran Abu Aboud, Primo N. Lara &Robert H. Weiss Research in many cancers has uncovered changes in metabolic pathways that control tumour energetics and biosynthesis, so-called metabolic reprogramming. Studies in clear cell renal cell carcinoma (ccRCC) have been particularly revealing, leading to the concept that ccRCC is a metabolic disease. ccRCC is generally accompanied
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Review Source Type: research

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ConclusionIn summary, we propose that SCAMP1 affects RCC tumorigenesis through miR-429 and its downstream targets. Our findings will contribute to development of biomarkers and therapeutics for RCC.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionsIn our experience, patients with PSM after PN can be managed conservatively with satisfactory long-term oncological outcomes.ResumenIntroducciónLa nefrectomía parcial (NP) es el tratamiento de elección para el tumor renal pequeño y localizado (cT1). Uno de los puntos de debate respecto a esta técnica es el manejo de los márgenes de resección afectados/positivos (MP). Presentamos los resultados oncológicos a largo plazo en pacientes con MP tras NP manejados conservadoramente.Material y métodosEn nuestro centro entre el año 1990 y 2011 se realiz...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
In conclusion, results showed that adipose microenvironment can regulate the behavior of tumor and non tumor human renal epithelial cells. PMID: 31534630 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study aimed to evaluate the density of CD8+ and CD3+ tumor-infiltrating lymphocytes (TILs) and determine whether the immunoscore has any prognostic effect on the oncological outcomes in patients with clear cell renal cell carcinoma (RCC).Materials and methodsA total of 129 patients diagnosed with clear cell RCC following radical or partial nephrectomy between 2009 and 2014 were retrospectively analyzed. Both tumor core (CT) and the invasive margin of nephrectomy specimens were assessed. The specimens were immunostained for anti-CD8+ and anti-CD3+ TILs. The patients were divided into three groups (favorable, intermedia...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionOur analysis of targeted therapies for advanced RCC in VHA suggests duration of treatment is shorter in a real ‐world setting than in clinical trials, and dose reductions and ADEs are more common.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Abstract BACKGROUND: Nivolumab has become an effective treatment option for cancer in various sites; however, this drug may cause immune-related adverse effects due to its mechanism of action. Furthermore, little has been reported on thiamine deficiency (TD) in patients receiving nivolumab treatment. METHOD: From a series of cancer patients, we reported a patient with recurrent renal cell carcinoma who developed TD after the start of nivolumab treatment. RESULTS: A 74-year-old man with recurrent renal cell carcinoma was referred to the psycho-oncology department as he had lost about 4 kg and displayed a ...
Source: Palliative and Supportive Care - Category: Palliative Care Authors: Tags: Palliat Support Care Source Type: research
Publication date: Available online 17 September 2019Source: Journal of Advanced ResearchAuthor(s): Peio Errarte, Gorka Larrinaga, José I. LópezAbstractCancer-associated fibroblasts (CAF) are a cellular compartment of the tumor microenvironment with critical roles in tumor development. Fibroblast activation protein-α (FAP) is one of the proteins expressed by CAF and its immunohistochemical detection in routine practice is associated with tumor aggressiveness and shorter patient survival. For these reasons, FAP seems a good prognostic marker in many malignant neoplasms, including renal cell carcinoma (RCC...
Source: Journal of Advanced Research - Category: Research Source Type: research
Contributors : Jarno Drost ; Marcel KoolSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensKidney tumours are among the most common solid tumours in children, comprising several distinct subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-clinical cell models capturing the disease heterogeneity are currently lacking. Here, we describe the first paediatric cancer organoid biobank. It contains tumour and matching normal kidney organoids from over 50 children with different subtypes of kidney cancer, including Wilms tumours, malignant rhabdoid tumours, renal...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
Cancers, Vol. 11, Pages 1394: Interleukin4Rα (IL4Rα) and IL13Rα1 Are Associated with the Progress of Renal Cell Carcinoma through Janus Kinase 2 (JAK2)/Forkhead Box O3 (FOXO3) Pathways Cancers doi: 10.3390/cancers11091394 Authors: Mi-Ae Kang Jongsung Lee Sang Hoon Ha Chang Min Lee Kyoung Min Kim Kyu Yun Jang See-Hyoung Park Specific kinds of interleukin (IL) receptors are known to mediate lymphocyte proliferation and survival. However, recent reports have suggested that the high expression of IL4Rα and IL13Rα1 in tumor tissue might be associated with tumorigenesis i...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
The objective of the study presented was to search for further arguments in favor of an SSM with isPM. For that purpose, the factor’s histology, grading, and singular/multiple pancreas metastases were analyzed on the basis of 814 observations published up to 2018. While histology and grading allowed for no conclusions regarding the importance of an SSM, the comparison of singular/multiple pancreas metastases produced arguments in favor of an SSM: 1. The multiple pancreas metastases observed in 38.1% prove that multiple tumor cell embolisms occur with isPM, the exclusive “maturation” of which i...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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