Basic research: PHD inhibitors miss their mark

Nature Reviews Nephrology 13, 384 (2017). doi:10.1038/nrneph.2017.75 Author: Katharine H. Wrighton Kiriakidis et al. show that small molecule inhibitors of prolyl hydroxylase domain (PHD) enzymes, which were developed as treatment for renal anaemia through activation of hypoxia inducible factor, suppress the secretion of complement C1q in vitro and in mice. C1q requires prolyl
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research