Autoimmunity: HLA-mediated protection in Goodpasture disease

Nature Reviews Nephrology 13, 381 (2017). doi:10.1038/nrneph.2017.71 Author: Ellen F. Carney A new study provides insights into the molecular mechanisms of HLA-mediated susceptibility and protection in Goodpasture disease (GPD). This rare renal disorder is characterized by autoimmune responses to the non-collagenous domain of the α3 chain of type IV collagen (α3(IV)NC1). Expression of HLA-DR15 is associated
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research