Stroke in HIV-infected individuals with and without HCV coinfection in Spain in the combination antiretroviral therapy era

by Alejandro Alvaro-Meca, Juan Berenguer, Asunci ón Díaz, Dariela Micheloud, Teresa Aldámiz-Echevarría, Chiara Fanciulli, Salvador Resino The incidence of stroke in human immunodeficiency virus (HIV)–infected individuals has been well analyzed in recent epidemiological studies. However, little is known about the specific contribution of hepatitis C virus (HCV) infection to stroke among HIV-infected individuals. The aims of this st udy were to analyze trends in the incidence rates of stroke in HIV-infected individuals during the combination antiretroviral (cART) era in Spain and to categorize them by the presence or absence of HCV coinfection. We analyzed hospital discharges with a diagnosis of stroke in Spain according to ICD -9-CM during 1997–2013. The study period was divided into four calendar periods (1997–1999, 2000–2003, 2004–2007, and 2008–2013). Patients were classified according to HCV serology. The number of HIV-infected patients was estimated based on data from the National Centre of Epidemiology. We calculated incidence rates (events per 10,000 patient-years) and in-hospital case fatality rates (CFR). The incidence of hemorrhagic stroke (HS) decreased in HIV-monoinfected patients (15.8 [1997–1999] to 6.5 [2008–2013];P
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research

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Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
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Source: Neurologia - Category: Neurology Source Type: research
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Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: The Neurologist - Category: Neurology Tags: Case Report/Case Series Source Type: research
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Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Treat Options Neurol Source Type: research
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Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
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Source: Health Care Renewal - Category: Health Management Tags: aliromucab evidence-based medicine health care prices manipulating clinical research PCSK9 inhibitor Praluent Regeneron Sanofi-Aventis Source Type: blogs
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