Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation.

Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation. Exp Neurol. 2017 Jun 10;: Authors: Oblinger JL, Burns SS, Huang J, Pan L, Ren Y, Shen R, Douglas Kinghorn A, Bradley Welling D, Chang LS Abstract Meningiomas frequently display activation of the PI3K/AKT/mTOR pathway, leading to elevated levels of phospho-4E binding proteins, which enhances protein synthesis; however, it is not known whether inhibition of protein translation is an effective treatment option for meningiomas. We found that human meningiomas expressed high levels of the three components of the eukaryotic initiation factor 4F (eIF4F) translation initiation complex, eIF4A, eIF4E, and eIF4G. The expression of eIF4A and eIF4E was important in sustaining the growth of NF2-deficient benign meningioma Ben-Men-1 cells, as shRNA-mediated knockdown of these proteins strongly reduced cell proliferation. Among a series of 23 natural compounds evaluated, silvestrol, which inhibits eIF4A, was identified as being the most growth inhibitory in both primary meningioma and Ben-Men-1 cells. Silvestrol treatment of meningioma cells prominently induced G2/M arrest. Consistently, silvestrol significantly decreased the amounts of cyclins D1, E1, A, and B, PCNA and Aurora A. In addition, total and phosphorylated AKT, ERK and FAK, which have been shown to be important drivers for meningioma cell proliferation, were markedly lower in silv...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

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We are once again at the start of a workweek. So I thought this would be a good time to share 87 of the most inspirational work quotes. Quotes that will motivate you, help you to focus and work smarter and also reduce the stress and pressure you may feel at work (or in school). These quotes have helped me many times to re-ignite my own motivation on a rough or bad day and to find a calmer and less stressed focus so I could keep working consistently towards my own goals and dreams. I hope they will help you to do the same. Motivational Quotes for Work “Concentrate all your thoughts upon the work in hand. The sun's ra...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - Category: Consumer Health News Authors: Tags: Personal Development Source Type: blogs
Did the movie Joker portray mental illness correctly and does it matter? We passionately go over the movie Joker from the lense of people living with mental illness and discuss whether or not there are implications of making a movie like this. Does it help us or hurt us? What if it does both? Listen in to hear Gabe’s freakishly good recollection of scenes from the movie as Jackie struggles to separate entertainment from reality.  Spoiler Alert: You don’t need to see Joker to appreciate this conversation but we do go over the plot and reveal some important scenes from the movie. (Transcript Available Below)...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Antidepressant Antipsychotic Depression Minding the Media Not Crazy Podcast Source Type: blogs
Pig skin isn ’t just for football these days.  Massachusetts General Hospital surgeons have successfully used genetically engineered pig skin for the temporary closure of a burn wound, the first time pig tissue derived from an animal with gene edits has been transplanted directly onto a human wound.  The F DA-cleared phase one clinical trial was led by surgeon Dr. Jeremy Goverman of MGH's Sumner Redstone Burn Center.  “It is not the trial itself that is so mind-boggling and intriguing to…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Z Sahraei, B Abtahi-Naeini, A SaffaeiNigerian Journal of Clinical Practice 2019 22(10):1462-1462
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
Publication date: Available online 12 October 2019Source: BurnsAuthor(s): Julia Elrod, Dirk Moellmeier, Clemens Schiestl, Christoph Mohr, Kathrin NeuhausAbstractBackgroundOptimal management of palmar hand burns in children is controversial. We aimed to compare function and aesthetics of retroauricular full thickness skin grafts (FTSG) to plantar glabrous split thickness skin grafts (STSG).Methods32 palmar grafts in paediatric burn patients were analysed: 19 retroauricular FTSG (group 1) and 13 thick plantar glabrous STSG (group 2). The latter were harvested at a thickness of 0.5 mm. The resulting plantar donor defec...
Source: Burns - Category: Dermatology Source Type: research
Publication date: Available online 11 October 2019Source: BurnsAuthor(s): Helen Zhang, Weikai Qu, Munier Nazzal, Jorge OrtizAbstractObjectiveTo determine if history of kidney transplant is an independent risk factor for increased incidence of wound infection and other morbidities in burn patients.BackgroundWhile the goal of immunosuppression post-organ transplantation is to prevent graft rejection, it is often associated with significant adverse effects such as increased susceptibility to infection, drug toxicity, and malignancy. Burn injuries lead to a dysregulated hypermetabolic state and a compromised cutaneous barrier,...
Source: Burns - Category: Dermatology Source Type: research
I burnt out as a GP but in mental health I could take time with patients and, at last, make a difference“If you’re going to reject me, then reject me,” I said. I was deep in the bowels of Leicester University, being interviewed for a place at medical school. I was 35, a fact the learned professor interviewing me returned to again and again. How would I cope with the workload? Would the four hour s’ driving each day prove too much? How would I support myself through my studies? Concerns that travelled through my own mind. Unlike the questions I asked myself, though, the queries in that interview room...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: NHS Mental health Life and style Society Psychology Science & wellbeing Source Type: news
Publication date: Available online 10 October 2019Source: Journal of Materials Research and TechnologyAuthor(s): Maria Vardaki, Shiva Mohajernia, Aida Pantazi, Ionela Cristina Nica, Marius Enachescu, Anca Mazare, Ioana Demetrescu, Patrik SchmukiAbstractThe primary focus of the paper is the fabrication of nanotubes via a two steps anodizing procedure on a TiZr substrate followed subsequent annealing treatments and their effect on surface and biocompatibility. The two step anodizing process is optimized for obtaining uniform and ordered nanotubular structures, that are then annealed in air or reduced in an Ar/H2 environment....
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Condition:   Second-degree Burn of Children Intervention:   Device: dressing with hyaluronic acid Sponsor:   Laboratoires Genévrier Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Deep Partial-thickness Burn Intervention:   Biological: StrataGraft skin tissue Sponsor:   Stratatech, a Mallinckrodt Company Temporarily not available
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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