The Time is Now to Move Far Beyond the Pill

There has been a lot of talk about ‘beyond the pill'strategies for many years, as companies create services and solutions that are complementary to their drugs. More recently, with the many changes affecting healthcare, pharma companies are adjusting their business models and looking at strategies to improve patient outcomes and diversify revenue sources that go far beyond the pill.Wellness programs and chronic disease management are common approaches, offering opportunities for companies to increase customer engagement leading to improved outcomes. For example, Biogen has used Fitbits to monitor the walking activity of patients with multiple sclerosis, previously only measured during visits to the doctor ’s office.This is a good example of an integrated solution that help patients achieve better health outcomes by engaging them with the process. Tracking their own progress – and seeing what other patients are doing – can build community and encouragement. Such communication is especially important in chronic long-term conditions where patient engagement is critical for improved outcomes.Wearables, ingestables, and implantables offer many new opportunities for pharma companies to become involved in the overall health of their customers, as well as to know how well their medicines are working. As technology becomes a bigger part of pharma, it's likely that medications will have an accompanying mobile app, with devices to track a drug's outcome.Leadershi...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news

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Publication date: Available online 21 October 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Ryan M Pearson, Joseph R Podojil, Lonnie D Shea, Nicholas JC King, Stephen D Miller, Daniel R GettsAbstractAutoimmune diseases, such as celiac disease, multiple sclerosis, and type 1 diabetes, are leading causes of morbidity and mortality in the United States. In these disease states, immune regulatory mechanisms fail that result in T and B cell-mediated destruction of self-tissues. The known role of T cells in mediating autoimmune diseases has led to the emergence of numerous therapies aimed at inactivati...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
. Harnett William Harnett Parasitic helminths and their isolated secreted products show promise as novel treatments for allergic and autoimmune conditions in humans. Foremost amongst the secreted products is ES-62, a glycoprotein derived from Acanthocheilonema viteae, a filarial nematode parasite of gerbils, which is anti-inflammatory by virtue of covalently-attached phosphorylcholine (PC) moieties. ES-62 has been found to protect against disease in mouse models of rheumatoid arthritis, systemic lupus erythematosus, and airway hyper-responsiveness. Furthermore, novel PC-based synthetic small molecule analogues (SMAs)...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
This study aimed to evaluate the possible influence of the most frequent vascular risk factors on brain volume in MS, also exploring the burden of their combined effects.MethodsMS patients with at least one vascular risk factor and a control group of MS patients were enrolled. Patients underwent brain MRI and the volumes of the whole brain (WB), white matter (WM), grey matter (GM), and cortical GM were estimated by SIENAX. Longitudinal atrophy was assessed by SIENA.ResultsThe sample included 326 MS patients, of these 49 (15%) had diabetes mellitus, 44 (13.4%) hypertension and 50 (15.3%) were active smokers. Multiple regres...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Abstract This review presents some examples of studies using the European rabbit (Oryctolagus cuniculus) that have led to, and continue to, contribute to advancement of understanding of human diseases as well as therapeutics development. In addition, we tabulate FDA-approved rabbit polyclonal and rabbit monoclonal antibodies (mAbs) that are used for diagnostic applications, as well as an overview of some "humanized" or otherwise altered rabbit mAbs that are in initial phase I, II, or advanced to phase III clinical trials. Information about endogenous retriviruses learned from studies of rabbits and other...
Source: Developmental and Comparative Immunology - Category: Allergy & Immunology Authors: Tags: Dev Comp Immunol Source Type: research
FDA-cleared objective device, objectiveFIELD, tests both eyes open simultaneously in a non-contact manner. objectiveFIELD is easy to administer and takes a few minutes to complete different examinations including normal, glaucoma, macular degeneration, diabetic retinopathy, multiple sclerosis, epilepsy, migraine, concussion, and other neuro-vision conditions. This story is related to the following:Medical Devices
Source: Industrial Newsroom - Health, Medical and Dental Supplies - Category: Medical Devices Source Type: news
AbstractMany  central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an u nder-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating dam...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
Abstract Several studies report the effects of excessive use of sugars and sweeteners in the diet. These include obesity, cardiac diseases, diabetes, and even lymphomas, leukemias, cancers of the bladder and brain, chronic fatigue syndrome, Parkinson's disease, Alzheimer's disease, multiple sclerosis, autism, and systemic lupus. On the other hand, each sugar and sweetener has a distinct metabolic assimilation process, and its chemical structure plays an important role in this process. Several scientific papers present the biological effects of the sugars and sweeteners in relation to their chemical structure. One ...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Abstract The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central regulator of redox, metabolic, and protein homeostasis that intersects with many other signaling cascades. Although the understanding of the complex nature of NRF2 signaling continues to grow, there is only one therapeutic targeting NRF2 for clinical use, dimethyl fumarate, used for the treatment of multiple sclerosis. The discovery of new therapies is confounded by the fact that NRF2 levels vary significantly depending on physiological and pathological context. Thus, properly timed and targeted manipulation o...
Source: Annual Review of Pharmacology and Toxicology - Category: Drugs & Pharmacology Authors: Tags: Annu Rev Pharmacol Toxicol Source Type: research
Autoimmune diseases commonly affect women of childbearing age, yet the risk of adverse pregnancy outcomes among women with autoimmune disease is underexamined. We hypothesized pregnancies complicated by Type 1 diabetes mellitus (T1DM), systemic lupus erythematosus (SLE) Crohn ’s disease, multiple sclerosis (MS) or rheumatoid arthritis (RA) would have increased risk of preeclampsia, preterm birth (PTB), small for gestational age (SGA), respiratory distress syndrome (RDS), and neonatal intensive care (NICU) admission.
Source: Annals of Epidemiology - Category: Epidemiology Authors: Source Type: research
ConclusionsEvidence points to a potential relationship between PA and exercise and risk factors related to vascular comorbidities in people with MS. PA and exercise training interventions may represent an effective therapeutic strategy for managing vascular comorbidities in people with MS, justifying further investigation.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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