The Time is Now to Move Far Beyond the Pill

There has been a lot of talk about ‘beyond the pill'strategies for many years, as companies create services and solutions that are complementary to their drugs. More recently, with the many changes affecting healthcare, pharma companies are adjusting their business models and looking at strategies to improve patient outcomes and diversify revenue sources that go far beyond the pill.Wellness programs and chronic disease management are common approaches, offering opportunities for companies to increase customer engagement leading to improved outcomes. For example, Biogen has used Fitbits to monitor the walking activity of patients with multiple sclerosis, previously only measured during visits to the doctor ’s office.This is a good example of an integrated solution that help patients achieve better health outcomes by engaging them with the process. Tracking their own progress – and seeing what other patients are doing – can build community and encouragement. Such communication is especially important in chronic long-term conditions where patient engagement is critical for improved outcomes.Wearables, ingestables, and implantables offer many new opportunities for pharma companies to become involved in the overall health of their customers, as well as to know how well their medicines are working. As technology becomes a bigger part of pharma, it's likely that medications will have an accompanying mobile app, with devices to track a drug's outcome.Leadershi...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news

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The objective of this review is to provide a broad overview on current strategies for brain drug delivery and related subjects from the past five years. It is hoped that this review could inspire readers to discover possible approaches to deliver drugs into the brain. After an initial overview of the BBB structure and function in both healthy and pathological conditions, this review re-visits, according to recent publications, some questions that are controversial, such as whether nanoparticles by themselves could cross the BBB and whether drugs are specifically transferred to the brain by actively targeted nanoparticles. ...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
Earlier this year at the Health 2.0 WinterTech Conference, the Robert Wood Johnson Foundation (RWJF) and Catalyst @ Health 2.0 launched the RWJF Opioid Challenge, an initiative aimed at bringing together healthcare and technology innovators to s...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Net News Pain Management Psychiatry Public Health Rehab Source Type: blogs
Purpose of review The autoimmune ecology refers to the interactions between individuals and their environment leading to a breakdown in immune tolerance and, therefore, to the development of one or more autoimmune diseases in such an individual. Herein, an update is offered on four specific factors associated with autoimmune diseases, namely, vitamin D, smoking, alcohol and coffee consumption from the perspective of exposome and metabolomics. Recent findings Smoking is associated with an increased risk for most of the autoimmune diseases. Carbamylation of proteins as well as NETosis have emerged as possible new pathop...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: INFECTIONS AND ENVIRONMENTAL ASPECTS OF AUTOIMMUNITY: Edited by Yehuda Shoenfeld Source Type: research
In conclusion, this population-based study demonstrates an assoc iation of DPP4i intake with three autoimmune and inflammatory diseases noted to be part of a distinct autoimmune cluster that includes multiple sclerosis, psoriasis, thyroiditis, bullous pemphigoid, and inflammatory bowel disease. Experimental studies are required to define the role of DPP4i in this autoimmune cluster.
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research
Publication date: August 2018 Source:Biomedicine & Pharmacotherapy, Volume 104 Author(s): Jelena Jakovljevic, C. Randall Harrell, Crissy Fellabaum, Aleksandar Arsenijevic, Nemanja Jovicic, Vladislav Volarevic Due to their trophic and immunoregulatory characteristics mesenchymal stem cells (MSCs) have tremendous potential for use in a variety of clinical applications. Challenges in MSCs’ clinical applications include low survival of transplanted cells and low grafting efficiency requiring use of a high number of MSCs to achieve therapeutic benefits. Accordingly, new approaches are urgently needed in order to over...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conclusions: A potent and selective S1PR2 ligand TZ59130 was identified in vitro. The radiosynthesis of [11C]TZ59130 was achieved with good radiochemical yield and high purity. The biodistribution study in SD rats indicated [11C]TZ59130 had high uptake (%ID/g) in the kidney at 5 min and fast washout in vivo. Further investigation of [11C]TZ59130 on streptozotocin (STZ)-induced diabetic rats is ongoing in our laboratory. Research support: National Multiple Sclerosis Society: #RG150705331, Department of Energy: #DESC0008432.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Cardiovascular, Endocrine & amp; Other II Source Type: research
Authors: Sárközy M, Kahán Z, Csont T Abstract Small non-coding RNAs including microRNAs (miRNAs) have been recently recognized as important regulators of gene expression. MicroRNAs play myriads of roles in physiological processes as well as in the pathogenesis of a number of diseases by translational repression or mRNA destabilization of numerous target genes. The miR-106b-25 cluster is highly conserved in vertebrates and consists of three members including miR-106b, miR-93 and miR-25. MiR-106b and miR-93 share the same seed sequences; however, miR-25 has only a similar seed sequence resulting in...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 2 May 2018 Source:Multiple Sclerosis and Related Disorders Author(s): Simon B N Thompson, Alister Coleman, Nicola Williams Yawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18-69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three had ...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
FDA is cracking down on stem cell clinics that market unapproved products and don't meet good manufacturing practice requirements. On behalf of the agency, the Department of Justice filed two complaints in federal court this week seeking permanent injunctions against a Florida-based clinic and a California-based clinic.  “Cell-based regenerative medicine holds significant medical opportunity, but we’ve also seen some bad actors leverage the scientific promise of this field to peddle unapproved treatments that put patients’ health at risk. In some instances, patients have suffered serious and per...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Source Type: news
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