Evaluation of a seminal vesicle biopsy protocol simultaneous to diagnostic prostate biopsy. Analysis of indication criteria.
CONCLUSIONS: Our seminal vesicle biopsy protocol has detected 22.2% of seminal vesicle invasion. The detection of a suspicious node at the prostate base has shown the greatest association with T3b. PMID: 28613201 [PubMed - in process]
Receptor tyrosine kinases (RTKs) are important drivers of cancers. In addition to genomic alterations, aberrant activation of WT RTKs plays an important role in driving cancer progression. However, the mechanisms underlying how RTKs drive prostate cancer remain incompletely characterized. Here we show that non-proteolytic ubiquitination of RTK regulates its kinase activity and contributes to RTK-mediated prostate cancer metastasis. TRAF4, an E3 ubiquitin ligase, is highly expressed in metastatic prostate cancer. We demonstrated here that it is a key player in regulating RTK-mediated prostate cancer metastasis. We further i...
CONCLUSION: Our study showed that after a 3 months delay, the risk of BCR was significantly higher for localized prostate cancer. It seemed possible to extend this period for low-risk patients, whereas it seemed necessary to keep it for intermediate-risks and to reduce it to 2 months for high-risks. LEVEL OF EVIDENCE: 4. PMID: 29907495 [PubMed - as supplied by publisher]
BACKGROUND: An elevated risk of suicide after a diagnosis of prostate cancer has been reported previously in the USA and Sweden. We aimed to identify whether prostate cancer survivors resident in New South Wales Australia are at higher risk of suicide and ...
PROSTATE cancer symptoms are triggered by a cancerous growth in this part of the male reproductive system. Early warning signs tend to include problems urinating, as the prostate tumour presses on the tubes for carrying urine. Watch out for these symptoms.
Research locates new genetic markers that may show an elevated risk of developing prostate cancer. This will help to identify men who need early screening.
Ushashi C. Dadwal, Eric S. Chang, Uma Sankar
Could changes in QTc duration during androgen deprivation therapy for prostate cancer help explain the increased risk for cardiovascular events in these patients?Journal of the Endocrine Society
ConclusionThe study of the metabolic alterations associated with PCa progression, accomplished by the analysis of PCa tissue by NMR, offers a promising approach for elucidating biochemical pathways affected by PCa and also for discovering new clinical biomarkers. The main metabolomic alterations associated with PCa development and promising biomarker metabolites for diagnosis of PCa were outlined.
ConclusionsRegular aspirin use may affect ribosome function in prostate tumors. Other putative target genes had similar expression in tumors from aspirin users and non-users. If results are corroborated by experimental studies, a potential benefit of aspirin may be limited to a subset of prostate cancer patients.
Wui Ann Woon, Paul B Ravindran, Piyasiri Ekayanake, Yivonne Yih Fang LimJournal of Medical Physics 2018 43(2):119-128The delivery consistency of a Varian Edge linear accelerator over the entire course of treatment for nasopharynx carcinoma (NPC) and prostate cancer intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) treatment plans was investigated using four different approaches. Three NPCs and three prostate plans were delivered in 34 and 29 consecutive days, respectively, using a Varian Edge equipped with a 120 high-definition (HD) multileaf collimator (MLC). All deliveries were meas...