Comparison of two on-line risk calculators versus the detection of circulating prostate cells for the detection of high risk prostate cancer at first biopsy.

CONCLUSIONS: CPC detection was superior to the other models in predicting the presence of clinically significant prostate cancer at initial biopsy; potentially reduces the number of unnecessary biopsy while missing few significant cancers. Being a positive/negative test it avoids defining a cutoff value which may differ between populations. Multicenter studies to validate this method are warrented. PMID: 28613202 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

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Conclusion: Collectively, our observations demonstrate the utility of PAI for temporal mapping of tumor hemodynamics and the value of PAI read-outs as surrogate measures of radiation response in HNSCC.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusions: This is the first preclinical investigation of MBs applied in PDT for PCa. PGL-MBs possess favorable CEUS imaging effects to enhance the localization of tumors. PGL-MBs with LFUS control PS accumulation at the tumor site to achieve highly effective PDT of PCa. This strategy carries enormous clinical potential for PCa management.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Based on findings from transrectal ultrasound guided (TRUS) biopsies series, standard sampling of the prostate targets the posterior/peripheral zone. However, a substantial proportion of PCa suspicious MRI PI-RADS ≥3 lesions is located in the anterior segment of the prostate, requiring a deeper placement and targeting of the biopsy needle.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
We appreciate the comments on our study. There is clearly a road ahead and paths to tread to find the exact place of ultrasound SWE in the detection and phenotypic characterization of prostate cancer. There may be a place of combining this with MRI. However, publications in this area to date show promising results. What should be considered a discriminatory diagnostic cutoff level for benign and malignant lesions can be debated but there is some confidence that all studies in this area show differences in the relative stiffness estimates not only of cancer and noncancerous tissues but also of different Gleason grades (refe...
Source: The Journal of Urology - Category: Urology & Nephrology Tags: Adult Urology Source Type: research
We describe a case of acute liver injury and migratory arthralgia in a patient receiving bicalutamide treatment for prostate cancer. A 67-year-old male with metastatic prostate cancer presented with a 6-day history of migratory arthralgia. He had been undergoing treatment with bicalutamide for 4 months; 3 weeks prior to symptom appearance the bicalutamide dose had been increased. He had no other symptoms. Liver tests and inflammatory markers were markedly elevated. Serology for hepatitis viruses A, B, and C, CMV, and EBV and autoimmune causes were all negative, and an ultrasound of the upper abdomen was normal. There was n...
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
Conclusions It has been shown that the test performance of PI-RADS v2 in research and clinical practice is improved, retaining higher accuracy over systematic TRUS biopsies for PCa diagnosis. Patient summary Multiparametric magnetic resonance imaging (MRI) and MRI-directed biopsies using the Prostate Imaging-Reporting and Data System improves the detection of prostate cancers likely to cause harm, and at the same time decreases the detection of disease that does not lead to harms if left untreated. The keys to success are high-quality imaging, reporting, and biopsies by radiologists and urologists working together in multi...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Conclusions Both techniques have comparable functional results, although the somewhat poorer oncological results for HIFU reflect a steeper learning curve, which could lead to its use in centers with high volumes of patients.
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
Prostate cancer is the second most common cancer in men worldwide [1], and is the fifth leading cause of cancer death in men with 307,500 deaths in 2012 [1]. Approximately two-thirds of prostate cancer cases are disproportionately diagnosed in the developed world, largely due to prostate cancer screening practices [1]. However, some detected cancers are so low grade and slow growing that they are unlikely to affect the individual in his lifetime [2]. Treatment with radical prostatectomy, brachytherapy, or external bean radiotherapy carries risks including erectile dysfunction and urinary incontinence [2].
Source: Canadian Association of Radiologists Journal - Category: Radiology Authors: Tags: Abdominal Imaging / Imagerie abdominale Source Type: research
Conclusion This two-center study shows that in men with BC in whom the prostate and PU were proven free of malignancy, PSC would represent a valid treatment option with excellent functional outcome. Oncologic outcomes were comparable to what is known from radical cystoprostatectomy series.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
We report results of repeat MRF-TB in men with continued suspicion for cancer and the institutional learning curve in detection of csPCa over time.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
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