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Comparison of two on-line risk calculators versus the detection of circulating prostate cells for the detection of high risk prostate cancer at first biopsy.

CONCLUSIONS: CPC detection was superior to the other models in predicting the presence of clinically significant prostate cancer at initial biopsy; potentially reduces the number of unnecessary biopsy while missing few significant cancers. Being a positive/negative test it avoids defining a cutoff value which may differ between populations. Multicenter studies to validate this method are warrented. PMID: 28613202 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

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Publication date: January 2018 Source:European Urology, Volume 73, Issue 1 Author(s): Guillaume Ploussard
Source: European Urology - Category: Urology & Nephrology Source Type: research
Abstract ObjectivesTo determine the performance of Prostate Health Index (PHI) density (PHID) combined with MRI and prior negative biopsy (PNB) status for the diagnosis of clinically‐significant prostate cancer (PCa). Patients &MethodsPatients without a prior diagnosis of PCa, with elevated PSA and a normal digital rectal exam who had PHI testing prospectively prior to prostate biopsy were included. PHID was calculated retrospectively using prostate volume derived from transrectal ultrasound at biopsy. Univariable and multivariable logistic regression modeling, along with receiver operating characteristic analysis, w...
Source: BJU International - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
MR imaging is an important part of prostate cancer diagnosis. Variations in quality and skill in general practice mean results are not as impressive as they were in academic centers. This observation provides an impetus to improve the method. Improved quality assurance will likely result in better outcomes. Improved characterization of clinically significant prostate cancer may assist in making MR imaging more useful. Improved methods of registering MR imaging with transrectal ultrasound imaging and robotic arms controlling the biopsy can reduce the impact of inexperienced operators and make the entire system of MR imaging...
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research
Publication date: January 2018 Source:Urology Case Reports, Volume 16 Author(s): Sangeet Ghai, Theodorus Van der Kwast The ExactVu™ Micro-Ultrasound system is a new high resolution imaging system for visualizing the prostate and has been FDA, CE, and Health Canada approved for visualization and biopsy of the prostate. The PRI-MUS™ (Prostate Risk Identification for Micro-Ultrasound) protocol has previously been demonstrated to correlate with risk of prostate cancer and severity of cancer. Here we present a case where a healthy 50 year old subject with no known risk factors volunteered to test the ExactVu system...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
CONCLUSION: MRGB increased PC detection in patients with previous biopsies and also increased SPC detection at the expense of decreasing NSPC detection in both groups of patients with fewer biopsies when compared with TRUS. These results demonstrate the value of MRGB in PC diagnosis. PMID: 29205162 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
Authors: Crisan N, Andras I, Radu C, Andras D, Coman RT, Tucan P, Pisla D, Crisan D, Coman I Abstract The use of grey scale prostate ultrasound decreased after the implementation of magnetic resonance imaging (MRI) for the diagnosis and evaluation of prostate cancer. The new developments, such as multiparametric ultrasound and MRI-ultrasound fusion technology, renewed the interest for this imaging method in the assessment of prostate cancer. The purpose of this paper was to review the current role of prostate ultrasound in the setting of these new applications. A thorough reevaluation of the sel...
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
DiscussionPeripheral zone PI-RADS 4 lesions with a DWI score of 4 are more likely Gleason 7+ cancer than those with a DWI score of 3. Lesions overcalled as PI-RADS 4 have PPV similar to published PI-RADS 3 data. Lesion shape and peripheral zone sparing in general do not predict Gleason 7+ cancer within PI-RADS 4 observations.
Source: Abdominal Imaging - Category: Radiology Source Type: research
Abstract ObjectivesTo evaluate the performance of transperineal robot‐assisted (RA) targeted (TB) and systematic (SB) prostate biopsy in the primary and repeat biopsy setting. Patients and MethodsPatients were admitted to RA biopsy between 2014‐2016. Prior to RA‐TB, multiparametric (mp) Magnetic Resonance Imaging (MRI) was performed. Prostate lesions were scored (Prostate Imaging, Reporting and Data System Version 2) and used for RA‐TB planning. In addition, RA‐SB was performed. Available, whole‐gland pathology was analyzed. Results130 patients were biopsy‐naive whereas 72 had previous negative transrectal ul...
Source: BJU International - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
BackgroundTo compare the incidence of newly diagnosed metastatic prostate cancer at an Australian facility pre‐ and post‐publication of the United States Preventive Services Task Force (USPSTF) guidelines and subsequent amendment of the Royal Australian College of General Practitioners Preventive Activities in General Practice guidelines. MethodsA retrospective analysis was undertaken by patients with newly diagnosed prostate cancer following transrectal ultrasound‐guided biopsy between 2009 and 2014. Patients were divided into two even groups based on whether they had undergone their transrectal ultrasound biopsy pr...
Source: ANZ Journal of Surgery - Category: Surgery Authors: Tags: Original Article Source Type: research
Abstract INTRODUCTION: The aim of this study was to compare the results of ultrasound-guided prostate biopsies (US-PB) and magnetic resonance imaging ultrasound fusion biopsies (MRI-PB) in two contemporary cohorts, and to describe the parameters orienting the choice of technique. METHODS: Two contemporary cohorts of patients undergoing US-PB or MR-PB using the Urostation® (Koelis, Grenoble, France) between November 2010 and July 2015 were analyzed retrospectively. Patients with metastatic cancer or recurrence after treatment, saturation biopsies, and US-PB performed after a negative MRI were excluded. Com...
Source: Canadian Urological Association Journal - Category: Urology & Nephrology Authors: Tags: Can Urol Assoc J Source Type: research
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