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Testicular Cancer Epidemiology in Developing Countries. Review of the literature.

CONCLUSIONS: A rise in the incidence of TC has been seen globally, this trend mainly in developing countries. In Colombia most studies are crossectional studies. By seeing the epidemiological data from some departments and the lack of specialists in those regions, it can be deduced the existence of an underreport of the disease that reveals the need to improve both surveillance systems and information registration, such as policies to achieve early diagnosis of TC. PMID: 28613204 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

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We report a case of a 19-year-old man presenting to our institute with a right testicular lesion, evidence of mediastinal and abdominal lymph node metastasis, and high levels of GCT serum biomarkers. After orchiectomy, the histopathological examination showed a mixed GCT: mature teratoma, immature teratoma, and histological features of testicular cancer regression (burned-out phenomenon). The patient underwent first-line chemotherapy (BEP regimen) which resulted in a complete instrumental and biochemical response after 4 cycles. Teratoma is considered a less aggressive type of GCT. In this particular case, metastatic disea...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Given the rarity of testicular germ cell tumors (TGCTs) and the complex aspects of management, we evaluate the effect of hospital TGCT case volume on overall survival outcomes and practice patterns.
Source: Urologic Oncology: Seminars and Original Investigations - Category: Urology & Nephrology Authors: Tags: Original article Source Type: research
Conclusion: A review of our case presents several unique factors. The above varying literature has shown our patient to have met the odds of a contralateral testicular primary development in that he had a nonseminomatous primary, followed by a second testicular primary seminoma. Our patient exceeded the 15-year cumulative risk of contralateral metachronous testicular cancer of 1.9% versus the seemingly contradictory 5.2% cumulative risk 25 years after the first testicular germ cell tumor. With his second primary (seminoma), he presented with the common retroperitoneal landing zone site, though with an uncommon involvement ...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: In the present study, we did not find support for an association between commonly used markers of inflammation and risk of testicular or penile cancer. The role of inflammation may be more complicated and require assessment of more specialised measurements of inflammation in future studies. PMID: 28900475 [PubMed]
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
Conclusion: Use of several organophosphate insecticides was associated with elevated breast cancer risk. However, associations for the women’s and husbands’ use of these insecticides showed limited concordance. Ongoing cohort follow-up may help clarify the relationship, if any, between individual insecticide exposures and breast cancer risk. https://doi.org/10.1289/EHP1295 Received: 28 October 2016 Revised: 25 April 2017 Accepted: 08 May 2017 Published: 06 September 2017 Address correspondence to L. Engel, Dept. of Epidemiology, University of North Carolina, CB #7435, Chapel Hill, NC 27599-7435 USA. Telep...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
We report the case of a patient who achieved complete remission (CR) of cisplatin-refractory metastatic pure seminoma after treatment with high-dose carboplatin and etoposide (CE) with peripheral blood stem cell transplantation as fourth-line chemotherapy. A 38-year-old man was diagnosed with advanced pure seminoma (pT3N3M1aS3). In the international germ cell consensus classification, his prognosis was classified as intermediate. He was treated with high-dose CE as fourth-line chemotherapy after treatment with BEP, VeIP, and TIN. After two cycles of high-dose CE, the concentrations of T-HCG and other tumor markers showed n...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
Conclusion: The meta-analysis indicates a role of the RASSF1A promoter hypermethylation from peripheral blood in TCGT. We confirmed that finding in our cohort study, which represents the first report of changed RASSF1A promoter methylation in peripheral blood TGCT.
Source: Cancer Genomics and Proteomics - Category: Cancer & Oncology Authors: Tags: Experimental Studies Source Type: research
Testicular germ cell tumour Seminoma (SGCT) is the most common type of testicular cancer affecting young adult men. In these men, the semen quality begin to decline along with disturbances in the reproductive hormones. There is a lack of literature examining proteomic changes at the spermatogenic level in samples banked prior to cancer treatment. We set out to identify the sperm proteins and their role in altered semen quality in SGCT patients by proteomics and bioinformatics tool.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
Following radical orchidectomy for testicular cancer, most patients undergo protocolled surveillance to detect tumour recurrences rather than receive adjuvant chemotherapy. Current United Kingdom national and most international guidelines recommend that patients require a chest x-ray (CXR) and serum tumour markers at each follow-up visit as well as regular CT scans; there is however, variation among cancer centres with follow-up protocols. Seminomas often do not cause tumour marker elevation; therefore, CT scans are the main diagnostic tool for detecting relapse.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Original Research Source Type: research
A blog reader, thank you!, told me about a study (same title as my post) that was recently published in the Journal of the National Cancer Institute and that has been picked up by a whole slew of online news sources and blogs, some with ominous titles such as “Alternative medicine kills cancer patients” or “Alternative medicine can kill you.” So what’s all the fuss about? Should we be concerned? Here’s the gist: a team of four Yale researchers carried out an observational case control study, comparing 280 cancer patients who had chosen to use ONLY alternative therapies to 560 patients wh...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll Use of Alternative Medicine for Cancer and Its Impact on Survival cancer deaths Skyler Johnson Source Type: blogs
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