Testicular Cancer Epidemiology in Developing Countries. Review of the literature.
CONCLUSIONS: A rise in the incidence of TC has been seen globally, this trend mainly in developing countries. In Colombia most studies are crossectional studies. By seeing the epidemiological data from some departments and the lack of specialists in those regions, it can be deduced the existence of an underreport of the disease that reveals the need to improve both surveillance systems and information registration, such as policies to achieve early diagnosis of TC. PMID: 28613204 [PubMed - in process]
ConclusionCurrently, no typical ultrasound features can definitively distinguish intratesticular adenomatoid tumors from malignant testicular masses. Thus, a surgical approach is almost always considered in such a case for both diagnostic and therapeutic purposes.
Publication date: Available online 6 January 2018 Source:Molecular and Cellular Endocrinology Author(s): Melissa Tharmalingam, Anne Jorgensen, Rod T. Mitchell The mammalian testis has two main roles, production of gametes for reproduction and synthesis of steroid- and peptide hormones for masculinization. These processes are tightly regulated and involve complex interactions between a number of germ and somatic cell-types that comprise a unique microenvironment known as the germ stem cell niche. In humans, failure of normal testicular development or function is associated with susceptibility to a variety of male reproduct...
Though the incidence of Testicular cancer among young is rising, little attention is given to promoting testicular self-examination which is recommended for its early prevention in developing countries. This stud...
This report describes an association between the X-linked agammaglobulinemia (XLA) contiguous BTK, TIMM8A, TAF7L gene syndrome and repeated testicular cancers. A previous Annals report described an association of XLA and Mohr-Tranebjaerg syndrome (MTS) in this now 28-year-old man first diagnosed at 11 months of age.1 The patient was diagnosed with XLA when he presented with acute bilateral flaccid paralysis subsequent to a varicella vaccination and was found to have hypogammaglobinemia (IgG,
PMID: 29307603 [PubMed - as supplied by publisher]
Mustafa Zafer Temiz, Omer Onur Cakir, Engin Kandirali, Atilla SemerciozIndian Journal of Urology 2018 34(1):91-92
To determine patient satisfaction with testicular prostheses (TP) for testicular cancer. Reconstruction represents an important part of surgical oncology, yet placement of TP following orchiectomy is infrequently performed. Improved data on patient satisfaction with TP would help in counseling patients with testicular cancer.
There were an estimated 8720 new cases of testicular cancer (TC) in the United States in 2016. The cause of the disease is complex, with several environmental and genetic risk factors. Although rare, the incidence has been steadily increasing. Fortunately, substantial advances in treatment have occurred over the last few decades, making TC one of the most curable malignancies. However, because TC typically occurs in younger men, considerations of the treatment impact on fertility, quality of life, and long-term toxicity are paramount; an individualized approach must be taken with patients based on their clinical and pathologic findings.
Primary testicular lymphomas (PTL) are the most prevalent type of testicular cancer arising in men over the age of 60. PTL accounts for approximately 1 –2% of all non-Hodgkin lymphomas and most present with localized disease but despite this, outcome is poor. The majority of cases represent an extranodal manifestation of diffuse large B-cell lymphoma (DLBCL), known as primary testicular DLBCL (PT-DLBCL). Gene expression profiling has established that over 75% of PT-DLBCLs resemble the activated B-cell-like (ABC) or non-germinal center subtype of nodal DLBCL.
Testicular cancer in 2017: Sequencing advances understanding, Published online: 19 December 2017; doi:10.1038/nrurol.2017.209Our biological understanding of TGCTs has been improved using sequencing, and molecular profiles associated with the genomic evolution and development of cisplatin resistance have been identified. The genomics of variants underpinning TGCT predisposition is being delineated. Studies of circulating microRNAs have demonstrated their potential for noninvasive diagnosis and disease monitoring.